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| 1 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 2 | Clinical applications of advanced magnetic resonance imaging techniques for arthritis evaluation显示文摘Magnetic resonance imaging(MRI) has allowed a comprehensive evaluation of articular disease, increasing the detection of early cartilage involvement, bone erosions, and edema in soft tissue and bone marrow compared to other imaging techniques. In the era of functional imaging, new advanced MRI sequences are being successfully applied for articular evaluation in cases of inflammatory, infectious, and degenerative arthropathies. Diffusion weighted imaging, new fat suppression techniques such as DIXON, dynamic contrast enhanced-MRI, and specific T2 mapping cartilage sequences allow a better understanding of the physiopathological processes that underlie these different arthropathies. They provide valuable quantitative information that aids in their differentiation and can be used as potential biomarkers of articular disease course and treatment response. | Teodoro Martín Noguerol Antonio Luna Marta Gómez Cabrera Alexie D Riofrio | 2017 | World Journal of Orthopedics2017，8，9： | 2 |
| 3 | Effects of drying and rewetting on carbon and nitrogen mineralization in soils and incorporated residues显示文摘 | Kruse J S Kissel D E Cabrera M L | 2004 | Nutr Cycl Agroeco- sys2004，69，： | 1 |
| 4 | Determinants of technical efficiency among dairy farms in Wisconsin显示文摘 | Cabrera V E Soils D Corral J | 2010 | Journal of Dairy Science2010，93，1： | 1 |
| 5 | Extrapolation and spectral estimation with iterative weighted norm modification显示文摘 | Cabrera S D Parks T W | 1991 | IEEE Transactions on Signal Processing1991，9，4： | 1 |
| 6 | Inverse association between serum resistin and insu- lin resistance in humans 显示文摘 | Ominguez Coello S Cabrera de Leon A Atmeida Gonzalez D | 2008 | Diabetes Res Clin Pract2008，82，2： | 1 |
| 7 | Learning technique to train neural networks as a state selector for inverter-fed induction machines using direct torque control 显示文摘 | Cabrera L A Elbuluk M E Zinger D S | 1997 | IEEE Trans on PE1997，12，5： | 1 |
| 8 | Anatomy of the left atrium:Implications for radiofrequency ablation of atrial fibrillation显示文摘 | HO SY SANCHEZ-QUINTANA D CABRERA JA | 1999 | J Cardiovasc Electrophysiol1999，10，11： | 1 |
| 9 | Influence of heavy metals on growth and ferrous sulphate oxidation by Acidithiobacillus ferrooxidans in pure and mixed cultures 显示文摘 | CABRERA G G6MEZ J M CANTERO D | 2005 | Process Biochemistry2005，40，8： | 1 |
| 10 | Film pressure distribution in water-lubricated rubber journal bearings显示文摘 | Cabrera D L Woolley N H | 2005 | Journal of Engineering Tribology2005，219，2： | 1 |
| 11 | Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir) 显示文摘 | Este JA Cabrera C Schols D | 1998 | Mol Pharmacol1998，53，2： | 1 |
| 12 | Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial fibrillation显示文摘 | SaNCHEZ-QUINTANA D CABRERA J A CLI MENT V | 2005 | Circulation2005，112，： | 1 |
| 13 | Nitrogen-form and endophyte-infection effects on growth, nitrogen uptake, and alkaloid content of chewings fescue turfgrass显示文摘 | Richardson M D Cabrera R I Murphy J A | 1999 | J Plant Nutrition1999，22，1： | 1 |
| 14 | How anatomy can guide ablation in isthmic atrial flutter显示文摘 | Cabrera JA Ho SY Sanchez-Quintana D | 2009 | Europ2009，11，1： | 1 |
| 15 | Fathers and mothers at play with their 2 - and 3 - year- olds: contributions to language and cognitive development 显示文摘 | TAMIS- LEMONDA C S SHANNON J D CABRERA N J | 2004 | Child Dev2004，75，6： | 1 |
| 16 | The treat- ment of open tibial fractures and of tibial non - union with a novel external fixator 显示文摘 | Ong C T Choon D S K Cabrera N P | 2002 | Injur2002，33，9： | 1 |
| 17 | The oxidant/antioxidant network: Role of melatonin 显示文摘 | Tan DX Cabrera J D'Apra D Sainz RM Mayo JC Ramos S | 1999 | Biol Signals Recept1999，8，12： | 1 |
| 18 | Aboveground and be- lowground competition between intercropped cabbage and young Eucalyptus torelliana显示文摘 | Nissen T M Midmore D J Cabrera M L | 1999 | Agroforestry Systems1999，46，1： | 1 |
| 19 | T-cell-line-tropic human immunodeficieney virus type 1 that is made resistant to stromal cell-derived factor 1α contains mutations in the envelope gp120 but does not show a switch in coreceptor use显示文摘 | Schols D Este J A Cabrera C | 1998 | J Virol1998，72，5： | 1 |
| 20 | Film pressure distribution in water-lubricated rubber journal bearings显示文摘 | CABRERA D L WOOLLEY N H ALLANSON D R | 2005 | IMechE2005，219，： | 1 |
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