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| 1 | Expression of the CagA gene of H.pylori and application of its product显示文摘INTRODUCTION Helicobaeter PYlori(HP)Plays an important role inthe uPPer digestive traet diseases.It can be dividedinto two main groups(toxie and non一toxieHP)aeeording to the | Han FC Yan XJ Su CZ | 2000 | World Journal of Gastroenterology2000，6，1： | 22 |
| 2 | Proteomic analysis of roots growth and metabolic changes under phosphorus deficit in maize (Zea mays L.) plants显示文摘 | Li, KP Xu, CZ Zhang, KW Yang, AF Zhang, JR | 2007 | 中国生物学文摘2007，21，11： | 16 |
| 3 | Gastroesophageal reflux: the features in elderlypatients显示文摘AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients. | Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F | 1999 | World Journal of Gastroenterology1999，5，5： | 12 |
| 4 | Gastroprotection induced by capsaicin in healthy human subjects显示文摘AIM: To evaluate the gastro-protectlve effect of capsaicin against the ethanol- and indomethacin (IND)-induced gastric mucosal damage in healthy human subjects. METHODS: The effects of small doses (1-8 μg/mL, 100 mL) of capsaicin on the gastric acid secretion basal acid output (BAO) and its electrolyte concentration, gastric transmucosal potential difference (GTPD), ethanol- (5 mL 300 mL/L i.g.) and IND- (3×25 mg/d) induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. RESULTS: Intragastric application of capsaicin decreased the BAO and enhanced 'non-parietal' component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3x400 μg i.g. CONCLUSION: Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings. | Gyula Mózsik János Szolcsányi István Rácz | 2005 | World Journal of Gastroenterology2005，11，33： | 10 |
| 5 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 6 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 7 | Gravity field and crustal structure of Gyirong-Lugu Region in western Xizang (Tibet) Plateau显示文摘THE Gyirong-Lugu gravity profile in western Xizang Plateau was carried out by Institute ofGeophysics,Chinese Academy of Sciences in 1994—1995.The data of this gravity profile fillthe gaps in the research of gravity field of western Xizang Plateau and provide basic informa-tion for the study of the whole structure and dynamical mechanism of Xizang Plateau. | Wang, QS Wu, CZ Jiang, WW | 1997 | Chinese Science Bulletin1997，42，8： | 3 |
| 8 | TEX——一种低易损炸药(英文)显示文摘根据低易损弹药 (LOVA)的分类就合成新炸药和复合炸药的问题进行了扼要分析 ,并对一些已知的炸药特性进行了讨论。认为 4 ,10 二硝基 4 ,10 二氮杂 2 ,6 ,8,12 四氧四环 [5.5.0 .0 5,9.0 3,1 1 ]十二烷 (TEX)是一种LOVA炸药 ,但是至今未见其广泛应用的报道 ,本文试图对炸药的现状及未来的发展寻找一种可能的解释。 | Jirˇí V?GENKNECHT (Department of Theory and Technology of Explosives,University of Pardubice,CZ 532 10 Pardubice) | 2000 | 含能材料2000，8，2： | 3 |
| 9 | Calculation of Wave Pressure and Pressure Spectrum for Perforate-Pipe Breakwater显示文摘Standing waves are formed due to the reflection when waves meet vertical wall,thereforestrong structures are needed to keep the wall stability under the serious wave attack.For the improvementof the working condition and increase of the stability of the wall,the lower reflecting breakwaters have at-tracted close attention Reports mostly from Japanese researchers are often concerned with the wall ofcaisson equipped with open windows.In this paper a kind of hollow-pipe perforated breakwater is exam-ined which waves may partially perforate into the harbour basin.The wave in front of the wall can onlyform partial standing wave and wave force is reduced obviously.And the theoretical calculation of waveforce and analysis of wave force spectrum are all derived.Comparison between the results from theoreticalcalculation and hydraulic modeling shows reasonable agreement. | Li, CZ Shi, HD Yu, DY Wang, AQ | 1997 | China Ocean Engineering1997，12，1： | 3 |
| 10 | Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy显示文摘AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 software.The Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal injury.Arthropathy patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were screened.Patients with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the study.During this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d omeprazole.At the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS results.The primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine treatment.RESULTS:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one month.Eight patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two patients.Ten patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was performed.When comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-treatment mean total LIS was detected in 7 patients who had moderate-tosevere enteropathy gradings at the inclusion CE (mean LIS:1615 ± 672vs 1064 ± 424,P=0.033).CONCLUSION:According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen. | István Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth | 2013 | World Journal of Gastroenterology2013，19，6： | 2 |
| 11 | Purification of liquid aluminum from nonmetallic inclusions in the electromagnetic field 显示文摘 | Barglik J Sajdak Cz | 1985 | Elektrowarme International1985，43，2： | 2 |
| 12 | Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis显示文摘Pathogeneticfactorsafectinggastroesophagealrefluxinpatientswithesophagitisandconcomitantduodenalulcer:amultivariateanalysisZH... | Zhu, HM Huang, X Deng, CZ Porro, GP Pace, F Sangaletti, O | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 13 | Effect of various surface modifications of wood flour on the properties of PP/wood composites显示文摘 | Lívia Dányádi János Móczó Béla Pukánszky | 2009 | Composites Part A2009，，2： | 2 |
| 14 | NEOLIGNAN GLUCOSIDES FROM PEDICULARIS TORTA显示文摘NEOLIGNANGLUCOSIDESFROMPEDICULARISTORTA￥ChangZengWANGandZhongJianJIA(InstituteofOrganicChemistryandStateKeyLaboratoryofApplie... | Wang, CZ Jia, ZJ | 1996 | Chinese Chemical Letters1996，7，2： | 2 |
| 15 | Purification and characterization of piceid beta-D- glucosidase from Aspergillus oryzae显示文摘 | Zhang CZ Li D Yu HS | 2007 | Process biochemistry2007，42，： | 1 |
| 16 | MicroRNAs modulate hematopoie-ic lineage differentiation显示文摘 | Chen CZ Li L Lodish HF | 2004 | Science2004，303，： | 1 |
| 17 | MicroRNAs modulate hematopoietic lineage differentiation 显示文摘 | Chen CZ Li L Lodish HF | 2004 | Science2004，303，5654： | 1 |
| 18 | Phenylpropanoid and iridoid glycosides from Pedicularis spicata显示文摘 | Jia ZJ Liu ZM Wang CZ | 1991 | Phytochemistry1991，30，11： | 1 |
| 19 | The Biological characteristics of SARS virus and its related coronavious显示文摘 | WANG CZ QI ZH | 2003 | Acta Biochim Biophysica Sinca2003，35，6： | 1 |
| 20 | Non-alcoholic fatty liver disease:from steatosis to cirrhosis显示文摘 | Farrell GC Larter CZ | 2006 | Hepatology2006，43，2： | 1 |
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