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| 1 | Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes显示文摘We recently reported that zacopride is a selective inward rectifier potassium current (IK1 ) channel agonist, suppressing ventricular arrhythmias without affecting atrial arrhythmias. The present study aimed to investigate the unique pharmacological properties of zacopride. The whole-cell patch-clamp technique was used to study IK1 currents in rat atrial myocytes and Kir2.x currents in human embryonic kidney (HEK)-293 cells transfected with inward rectifier potassium channel (Kir)2.1, Kir2.2, Kir2.3, or mutated Kir2.1 (at phosphorylation site S425L). Western immunoblots were performed to estimate the relative protein expression levels of Kir2.x in rat atria and ventricles. Results showed that zacopride did not affect the IK1 and transmembrane potential of atrial myocytes. In HEK293 cells, zacopride increased Kir2.1 homomeric channels by 40.7%±9.7% at 50 mV, but did not affect Kir2.2 and Kir2.3 homomeric channels, and Kir2.1-Kir2.2, Kir2.1-Kir2.3 and Kir2.2-Kir2.3 heteromeric channels. Western immunoblots showed that similar levels of Kir2.3 protein were expressed in rat atria and ventricles, but atrial Kir2.1 protein level was only 25% of that measured in the ventricle. In addition, 5-hydroxytryptamine (5-HT) 3 receptor was undetectable, whereas 5-HT 4 receptor was weakly expressed in HEK293 cells. The Kir2.1-activating effect of zacopride in these cells was abolished by inhibition of protein kinase A (PKA), but not PKC or PKG. Furthermore, zacopride did not activate the mutant Kir2.1 channel in HEK293 cells but selectively activated the Kir2.1 homomeric channel via a PKA-dependent pathway, independent to that of the 5-HT receptor. | ZHANG Li LIU QingHua LIU ChengFang ZHAI XuWen FENG QiLong XU RuiLing CUI XiangLi ZHAO ZhiQing CAO JiMin WU BoWei | 2013 | Science China(Life Sciences)2013，56，9： | 7 |
| 2 | Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ显示文摘 | Caibin Cui Cooper LF Xiangli Yang | 2003 | Mol Cell Biol2003，23，3： | 1 |
| 3 | Resveratrol suppresses colitis and colon cancer associated with colitis显示文摘 | CUI Xiangli JIN Yu HOFSETH A B | 2010 | Cancer Prev Res2010，3，： | 1 |
| 4 | Data Acquisition and Process Control System of Join显示文摘 | Cui Dongxu Li Xiangli Fang Yu and Sun Xingyun(Beijing Spring Electro-mechanical Advanced Technology Company) | 1994 | China Oil & Gas1994，1，4： | 1 |
| 5 | Analysis of CD137L and IL-17 expression in tumor tissue as prognostic indicators for gliblastoma显示文摘 | Xiangli Cui Zhiqin Xu Zhigang Zhao | 2013 | International Journal of Biological Sciences2013，9，： | 1 |
| 6 | Co-polysomy of chromosome lq and 19p predicts worse prognosis in lp/19q codeleted oligodendroglial tumors: FISH analysis of 148 consecutive cases显示文摘 | Xiaohui Ren Haihui Jiang Xiangli Cui | 2013 | Neuro-Oncology2013，15，9： | 1 |
| 7 | Thin-interbedded reservoirs prediction based on seismic sedimentology显示文摘Interference of thin-interbedded layers in seismic reflections has great negative impact on thin-interbedded reservoirs prediction.To deal with this,two novel methods are proposed that can predict the thin-interbedded reservoirs distribution through strata slices by suppressing the interference of adjacent layer with the help of seismic sedimentology.The plane distribution of single sand bodies in thin-interbedded reservoirs can be clarified.(1)The minimum interference frequency slicing method,uses the amplitude-frequency attribute estimated by wavelet transform to find a constant seismic frequency with the minimum influence on the stratal slice of target layer,and then an optimal slice corresponding the constant frequency mentioned above can be obtained.(2)The superimposed slicing method can calculate multiple interference coefficients of reservoir and adjacent layers of target geological body,and obtain superimposed slice by weighted stacking the multiple stratal slices of neighboring layers and target layer.The two proposed methods were used to predict the distribution of the target oil layers of 6 m thick in three sets of thin-interbedded reservoirs of Triassic Kelamayi Formation in the Fengnan area of Junggar Basin,Northwestern China.A comparison with drilling data and conventional stratal slices shows that the two methods can predict the distribution of single sand bodies in thin-interbedded reservoirs more accurately. | NI Changkuan SU Mingjun YUAN Cheng LIU Huaqing CUI Xiangli | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
| 8 | Summer habitat selection and impacts of human disturbance on leopard cats(Prionailurus bengalensis)显示文摘Introduction:As a consequence of habitat loss and degradation,the leopard cat(Prionailurus bengalensis)in China has become endangered and in need of urgent protection.In situ conservation of leopard cats must be based on an understanding of their habitat selection patterns.We studied the summer habitat of leopard cats using line-transect surveys in the northern Taihang Mountain region surrounding Beijing,China.We compared used plots with non-used plots in elevation,tree canopy,and 20 other ecological variables,and used Vanderploeg��Scavia’s resource selection index(VSI)to analyze habitat preferences.Outcomes/others:Results show that tree canopy,tree height,tree density,and stump quantity of used plots were significantly lower than non-used plots in summer,and that leopard cats preferred habitats located on northern,flat slopes with lower slope,shrub-dominated,dry soil,and less fallen-wood.Leopard cats had a strong tendency to use habitats near human disturbance areas with moderate levels of disturbance intensity.Conclusion:The results suggest that future conservation efforts should emphasize:(1)strengthening the protection and management of forest fringe shrub habitats to improve summer habitat suitability,and(2)environmental education and animal protection campaigns to promote community biodiversity conservation. | Jiayi Wu Jing Wang Yinjiu Zhu Xiangli Bu Rongwei Xiang Qingbin Lu Shaopeng Cui Yinghong Hao Yan Sheng Xiuxiang Meng | 2020 | Ecosystem Health and Sustainability2020，6，1： | 0 |
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