2篇
您的检索式：作者名="CUI Luming"
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| 1 | Aqueous extract of Taxus Chinensis (Pilger) Rehd inhibits lung carcinoma A549 cells through the epidermal growth factor receptor/mitogen-activated protein kinase pathway in vitro and in vivo显示文摘OBJECTIVE:To explore the anticancer mechanismof aqueous extract of Taxus Chinensis (Pilger) Rehd (AETC).METHODS: The serum pharmacological method was used to avoid interference from administration of the crude medicinal herbs. Eight purebred New Zealand rabbits were used for preparation of serum containing various concentrations of AETC. Forty-eightBalb/c-nu mice were used for in vivo experiments. The effects of serum containing AETC on the proliferation of A549 cells and expression levels of the epidermal growth factor receptor/mitogen-activated protein kinase(EGFR/MAPK) pathway-related proteins in vitro were investigated. Additionally, the effects on the growth of A549 xenografts in nudemice,and expression levels of the EGFR/MAPK pathway-related proteins in the xenografts,were investigated.RESULTS: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay revealed that the serum containing AETC significantly decreased the viability of A549 cells in a dose-dependent manner.Western blot showed that the serum containing various concentrations of AETC strongly reduced the levels of phospho-Jun N-terminal kinase(p-JNK) and phospho-extracellular signal-regulated kinase1/2(ERK1/2) while it increased the level of p-p38. However, no significant effects on the expression levels of JNK, ERK1/2, and p38 MAPK were found. In addition, an anticancer effect from AETC was observed invivo in the Balb/c-nu mice bearing A549xenografts.CONCLUSION: AETC has significant effects on the growth of A549 xenografts and on the activity of the EGFR/MAPK pathway. Therefore, AETC may be beneficial in lung carcinoma treatment. | Qijin Shu Minhe Shen Binbin Wang Qingli Cui Xiaoying Zhou Luming Zhu | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 10 |
| 2 | Spatial and temporal variabilities of rainstorms over China under climate change显示文摘Rainstorms are one of the extreme rainfall events that cause serious disasters,such as urban flooding and mountain torrents.Traditional studies have used rain gauge observations to analyze rainstorm events,but relevant information is usually missing in gauge-sparse areas.Satellite-derived precipitation datasets serve as excellent supplements or substitutes for the gauge observations.By developing a grid-based rainstorm-identification tool,we used the Tropical Rainfall Measurement Mission(TRMM)Multi-satellite Precipitation Analysis(TMPA)time series product to reveal the spatial and temporal variabilities of rainstorms over China during 1998–2017.Significant patterns of both increasing and decreasing rainstorm occurrences were detected,with no spatially uniform trend being observed across the whole country.There was an increase in the area being affected by rainstorms during the 20-year period,with rainstorm centers shifting along the southwest–northeast direction.Rainstorm occurrence was found to be correlated with local total precipitation.By comparing rainstorm occurrence with climate variables such as the El Ni?o-Southern Oscillation and Pacific Decadal Oscillation,we also found that climate change was likely to be the primary reason for rainstorm occurrence in China.This study complements previous studies that used gauge observations by providing a better understanding of the spatiotemporal dynamics of China’s rainstorms. | HUANG Chang ZHANG Shiqiang DONG Linyao WANG Zucheng LI Linyi CUI Luming | 2021 | Journal of Geographical Sciences2021，31，4： | 3 |
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