|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of Internet Literacy,Internet Addiction Symptoms on Quality of Life显示文摘As a country with the largest absolute number of Internet users in the world,China has witnessed that Internet addiction is becoming a prominent issue.Young adults like university students are particularly susceptible to the lure of the Internet,and they are described as being obsessed with the Internet.According to the latest report of the China Internet Network Information Center(CNNIC),netizens aged 20-29 have become the largest group of Internet users in China,accounting for 30.7%of the total Chinese netizens.Therefore,it is very important to study the Internet use and its influence among the young,since young people have become the main body of the Chinese Internet users.Focusing on the two essential factors closely related to Internet addiction as a risk,this study attempted to find out the interrelationships between Internet literacy,Internet addiction,and young people’s quality of life.As for research method,a paper-based survey was conducted to collect data and the final sample size was 1,000.The university student sample was created from a stratified sampling procedure with proportionate allocation among the nine universities in Dalian,a coast city in northeast China.Factor analyses showed different aspects of Internet literacy and various symptoms of Internet addiction among the university students.This study found that Internet addiction had some negative influences on the university students’quality of life.Moreover,the findings showed that Internet literacy has a significant influence on Internet addiction and quality of life among these young people.Basically,those university students with higher level of Internet literacy showed lower degree of Internet addiction and higher degree of quality of life.Therefore,in the future,more attention should be paid to education and activities in order to improve young people’s Internet literacy.The findings further enrich the literature of Internet addiction,Internet literacy,as well as quality of life,and are valuable for prevention,treatment,and recovery of Internet addiction among young people.Research on Internet addiction as an emerging risk in the Chinese context is of great research significance theoretically and practically,not only because Internet addiction is becoming a prominent issue in both China and many other societies,but also because it may act as a good case to study risk issue related to Internet,youth,and everyday life.The results can be used for future studies on Internet addiction,Internet literacy,and quality of life among other subpopulations or within other social contexts. | WU Wenying CUI Fangying | 2018 | Journalism and Mass Communication2018，8，4： | 2 |
| 2 | The CXCR4-CXCL12 axis promotes T cell reconstitution via efficient hematopoietic immigration显示文摘T cells play a critical role in immunity to protect against pathogens and malignant cells.T cell immunodeficiency is detrimental,especially when T cell perturbation occurs during severe infection,irradiation,chemotherapy,and age-related thymic atrophy.Therefore,strategies that enhance T cell reconstitution provide considerable benefit and warrant intensive investigation.Here,we report the construction of a T cell ablation model in Tg(coro1a:Den NTR)zebrafish via metronidazole administration.The nascent T cells are mainly derived from the hematopoietic cells migrated from the kidney,the functional homolog of bone marrow and the complete recovery time is 6.5 days post-treatment.The cxcr4b gene is upregulated in the responsive hematopoietic cells.Functional interference of CXCR4 via both genetic and chemical manipulations does not greatly affect T lymphopoiesis,but delays T cell regeneration by disrupting hematopoietic migration.In contrast,cxcr4b accelerates the replenishment of hematopoietic cells in the thymus.Consistently,Cxcl12b,a ligand of Cxcr4,is increased in the thymic epithelial cells of the injured animals.Decreased or increased expression of Cxcl12b results in compromised or accelerated T cell recovery,respectively,similar to those observed with Cxcr4b.Taken together,our study reveals a role of CXCR4-CXCL12 signaling in promoting T cell recovery and provides a promising target for the treatment of immunodeficiency due to T cell injury. | Fangying Zhao Yafang Lu Zhifan Li Jiangyong He Nianfei Cui Lingfei Luo Li Li | 2022 | Journal of Genetics and Genomics2022，49，12： | 1 |
| 3 | Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution显示文摘Immunocytes,including the microglia,are crucial in the neurodegenerative process in old people.However,the understanding regarding microglia heterogeneity and other involved immunocytes remains elusive.We analyzed 26,456 immunocytes from 12-and 26-month-old zebrafish brains at single-cell resolution.Microglia and T lymphocytes were detected in the brain at both time points.Two types of microglia were annotated,namely,ac+microglia and xr+microglia,which were clustered into subsets 1,2,3,4,5,and subsets 6,7,8,9,respectively.Diversified microglia predominated the adult brains and cooperated with T cells to perform the functions of immune response and neuronal nutrition.We validated the specific microglia markers.The novel transgenic lines,Tg(lgals3bpb:e GFP)and Tg(apoc1:e GFP),were created,which faithfully labeled ac+microglia and served as valuable labeling tools.However,the microglia population reduced while T cells of six subtypes intriguingly increased to serve as the primary immune cells in aged brains.Unlike in 12-month-old brains,T cells,together with microglia,exhibited a coordinated signature of inflammation in the 26-month-old brains.Our findings revealed the immunocytes atlas in aged zebrafish brains.It implied the involvement of microglia and T cells in the progression of neurodegeneration in aging. | Jiangyong He Fangying Zhao Bingyue Chen Nianfei Cui Zhifan Li Jie Qin Lingfei Luo Congjian Zhao Li Li | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员