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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 3 | Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis显示文摘AIM: To investigate if the clinical efficacy of granulocytes and monocytes by adsorption (GMA) is associated with an increased frequency of peripheral regulatory T cells (Tregs), as these cells have proven to be successful in suppressing inflammatory bowel disease (IBD) in animal models. METHODS: We report four cases of corticosteroid- dependent ulcerative colitis (UC) and two Crohn’s disease (CD) cases with severe cutaneous lesions who received GMA therapy. The frequency of CD4+ CD25high (Tregs) in peripheral blood was analyzed by flow cytometry and the expression of FoxP3 and TGF beta in purified CD4+ T cells was determined by real time PCR prior to and one month after the last apheresis session, and at the time of endoscopic and clinical assessing. RESULTS: Increased expression of Fox P3 mRNA was found in all five patients who responded to cytapheresis with remission of clinical symptoms, mucosal inflammation and cutaneous lesions, and an increased frequency of circulating Tregs was found in four patients. These changes were not observed in the patient with UC who did no respond to GMA. Variations in TGF-β (mRNA) did not parallel that of FoxP3 mRNA. CONCLUSION: The clinical efficacy of GMA on IBD and related extra intestinal manifestations was associated with an expansion of circulating CD4+ CD25+ Tregs and higher expression of FoxP3 in CD4+ T cells. Accordingly, an elevated CD4+ CD25+ FoxP3 may be a valuable index of remission in patients with IBD and other chronic relapsing-remitting inflammatory conditions during treatment with GMA. | Emilio Cuadrado Marta Alonso Maria Dolores de Juan Pilar Echaniz Juan Ignacio Arenas | 2008 | World Journal of Gastroenterology2008，14，10： | 6 |
| 4 | Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation显示文摘Antibody-mediated rejection(AMR) caused by donorspecific anti-human leukocyte antigen antibodies(DSA) is widely accepted to be a risk factor for decreased graft survival after kidney transplantation. This entity also plays a pathogenic role in other solid organ transplants as it appears to be an increasingly common cause of heart graft dysfunction and an emerging issue in lung transplantation. In contrast, the liver appears relatively resistant to DSA-mediated injury. This 'immune-tolerance' liver property has been sustained by a low rate of liver graft loss in patients with preformed DSA and by the intrinsic liver characteristics that favor the absorption and elimination of DSA; however, alloantibody-mediated adverse consequences are increasingly being recognized, and several cases of acute AMR after ABO-compatible liver transplant(LT) have been reported. Furthermore, the availability of new solid-phase assays, allowing the detection of low titers of DSA and the refinement of objective diagnostic criteria for AMR in solid organ transplants and particularly in LT, have improved the recognition and management of this entity. A cost-effective strategy of DSA monitoring, avoidance of class Ⅱ human leukocyte antigen mismatching, judicious immunosuppression attached to a higher level of clinical suspicion of AMR, particularly in cases unresponsive to conventional antirejection therapy, can allow a rational approach to this threat. | Antonio Cuadrado David San Segundo Marcos López-Hoyos Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，39： | 5 |
| 5 | Hybrid transvaginal cholecystectomy, NOTES, and minilaparoscopy: analysis of a prospective clinical series显示文摘 | José Noguera Carlos Dolz Angel Cuadrado José Olea Angels Vilella Rafael Morales | 2009 | Surgical Endoscopy2009，，4： | 5 |
| 6 | Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma显示文摘 | Antonio Cuadrado Aitor Orive Covadonga García-Suárez Agustín Domínguez Jose Carlos Fernández-Escalante Javier Crespo Fernando Pons-Romero | 2005 | Obesity Surgery2005，，3： | 4 |
| 7 | High-sensitivity integrated devices based on surface plasmon resonance for sensing applications显示文摘A metallic nanostructured array that scatters radiation toward a thin metallic layer generates surface plasmon resonances for normally incident light. The location of the minimum of the spectral reflectivity serves to detect changes in the index of refraction of the medium under analysis. The normal incidence operation eases its integration with optical fibers. The geometry of the arrangement and the material selection are changed to optimize some performance parameters as sensitivity, figure of merit, field enhancement, and spectral width. This optimization takes into account the feasibility of the fabrication. The evaluated results of sensitivity(1020 nm/RIU)and figure of merit(614 RIU^(-1)) are competitive with those previously reported. | MAHMOUD H.ELSHORBAGY ALEXER CUADRADO JAVIER ALDA | 2017 | Photonics Research2017，5，6： | 2 |
| 8 | 基于Jaccard的移动终端自动识别并行算法及其MapReduce实现(英文)显示文摘The ability of accurate and scalable mobile device recognition is critically important for mobile network operators and ISPs to understand their customers' behaviours and enhance their user experience.In this paper,we propose a novel method for mobile device model recognition by using statistical information derived from large amounts of mobile network traffic data.Specifically,we create a Jaccardbased coefficient measure method to identify a proper keyword representing each mobile device model from massive unstructured textual HTTP access logs.To handle the large amount of traffic data generated from large mobile networks,this method is designed as a set of parallel algorithms,and is implemented through the MapReduce framework which is a distributed parallel programming model with proven low-cost and high-efficiency features.Evaluations using real data sets show that our method can accurately recognise mobile client models while meeting the scalability and producer-independency requirements of large mobile network operators.Results show that a 91.5% accuracy rate is achieved for recognising mobile client models from 2 billion records,which is dramatically higher than existing solutions. | 刘军 李银周 Felix Cuadrado Steve Uhlig 雷振明 | 2013 | China Communications2013，10，7： | 2 |
| 9 | 笔记, MANOS, SILS 和另外的新 laparoendoscopic 技术显示文摘 A new way of opening a body cavity can be a revolution in surgery.In 1980s,laparoscopy changed how surgeons had been working for years.Natural orifice translumenal endoscopic surgery(NOTES),minilaparoscopy-assisted natural orifice surgery(MANOS),single incision laparoscopic surgery(SILS) and other new techniques are the new paradigm in our way of operating in the 21 st century.The development of these techniques began in the late 90s but they have not had enough impact to develop and evolve.Parallels between the first years of laparoscopy and NOTES can be made.Working for an invisible surgery,not only for cosmesis but for a less invasive surgery,is the target of NOTES,MANOS and SILS performed by surgeons and endoscopists over the last 10 years.The future flexible endoscopic platforms and the fusion between laparoscopic instruments and devices and robotic surgery will be a great advance for 'scarless surgery'. | José F Noguera Angel Cuadrado | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 2 |
| 10 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 11 | Comparison of esophageal stenoses produced by endoscopic sclerotherapy versus variceal ligation 显示文摘 | de la Pena J Orive A Cuadrado A | 2006 | Gastroenterol Hepatol2006，29，9： | 1 |
| 12 | Evidence-based recommendatlons for the prevention and long-term management of thrombosis in antiphos- pholipid antibody-positive patients:report of a task force at the 13th International Congress on antiphospholipid antibodies 显示文摘 | Ruiz IG Cuadrado MJ Ruiz Al | 2011 | Lupus2011，20，2： | 1 |
| 13 | Organometallics显示文摘 | Cuadrado I Morán M Casado C M | 1996 | 15:5 2781996，15，： | 1 |
| 14 | Lack of association between antiphospholipid antibody and WHO classification in lupus nephritis显示文摘 | Fofi C Cuadrado M J Godfrey T | 2001 | Clin Exp Rheumatol2001，19，1： | 1 |
| 15 | Skin manifestations of systemic lupus erythematosus refractory to multiple treatment modalities:poor results with mycophenolate mofetil显示文摘 | PISONICN OBERMOSER G CUADRADO MJ | 2005 | Clin Exp Rheumatol2005，23，3： | 1 |
| 16 | Neuropsychiatric man- ifestations in systemic lupus erythematosus;prevalence and associa- tion with antiphospholipid antibodies显示文摘 | Sanna G Bertolaccini ML Cuadrado MJ | 2003 | J Rheumatol2003，30，5： | 1 |
| 17 | Certral nervous system involvement in the antiphospholipid(Hughes)syndrome显示文摘 | Sanna G Bertolaccini ML Cuadrado M J | 2003 | Rheumatology2003，42，： | 1 |
| 18 | Study of spectral analytical data using fin- gerprints and scaledsimilarity measurements显示文摘 | M Urbano Cuadrado M D Luque de Castro M A Go mez-Nieto | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 19 | J Am Chem Soc显示文摘 | Castro R Cuadrado I Alonso B | 1997 | 119:5 7601997，119，： | 1 |
| 20 | Role of microglial redox balance in modulation of neuroinflammation显示文摘 | Innamorato NG Lastres-Becker I Cuadrado A | | 0，，： | 1 |
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