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| 1 | Strong motion observations and recordings from the great Wenchuan Earthquake显示文摘The National Strong Motion Observation Network System (NSMONS) of China is briefly introduced in this paper. The NSMONS consists of permanent free-field stations, special observation arrays, mobile observatories and a network management system. During the Wenchuan Earthquake, over 1,400 components of acceleration records were obtained from 460 permanent free-field stations and three arrays for topographical effect and structural response observation in the network system from the main shock, and over 20,000 components of acceleration records from strong aftershocks occurred before August 1, 2008 were also obtained by permanent free-field stations of the NSMONS and 59 mobile instruments quickly deployed after the main shock. The strong motion recordings from the main shock and strong aftershocks are summarized in this paper. In the ground motion recordings, there are over 560 components with peak ground acceleration (PGA) over 10 Gal, the largest being 957.7 Gal. The largest PGA recorded during the aftershock exceeds 300 Gal. | Li Xiaojun Zhou Zhenghua Yu Haiyin Wen Ruizhi Lu Dawei Huang Moh Zhou Yongnian Cu Jianwen | 2008 | Earthquake Engineering and Engineering Vibration2008,7,3: | 71 |
| 2 | ACCF/SCAI/SVMB/SIR/ASITN 2007年颈动脉支架置入术临床专家共识文件——美国心脏病学会基金会特别工作组关于临床专家共识文件的报告(ACCF/SCAI/SVMB/SIR/ASITN颈动脉支架置入术临床专家共识文件委员会):与美国介入与治疗神经放射学学会、心血管造影和介入治疗学会、血管医学和生物学学会、介入放射学学会联合发布显示文摘序言
本文件在美国心血管造影和介入治疗学会(Society for Cardiovascular Angiography and Interventions,SCAI)、血管医学和生物学学会(Society for Vascular Medicine and Biology,SVMB)、介入放射学学会(Society of Interventional Radiology,SIR)、美国介入与治疗神经放射学学会(American Society of Interventional & Therapeutic Neuroradiology,ASITN)共同倡导下, | Bates ER Babb JD Casey DE Jr Cates CU Duckwiler GR Feldman TE Gray WA Ouriel K Peterson ED Rosenfield K Rundback JH Safian RD Sloan MA White CJ 刘慧慧(译) 吴延华(译) 靳勇(译) 曹勇军(译) 刘春风(译) | 2007 | 国际脑血管病杂志2007,15,5: | 52 |
| 3 | Anaerobic microbiologically influenced corrosion mechanisms interpreted using bioenergetics and bioelectrochemistry: A review显示文摘Microbiologically influenced corrosion(MIC) is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a lack of deep understanding of the interactions between biofilms and metal surfaces, MIC occurrences and mechanisms are difficult to predict and interpret. Many theories and mechanisms have been proposed to explain MIC. In this review, the mechanisms of MIC are discussed using bioenergetics, microbial respiration types, and biofilm extracellular electron transfer(EET). Two main MIC types, namely EET-MIC and metabolite MIC(M-MIC), are discussed. This brief review provides a state of the art insight into MIC mechanisms and it helps the diagnosis and prediction of occurrences of MIC under anaerobic conditions in the oil and gas industry. | Yingchao Li Dake Xu Changfeng Chen Xiaogang Li Ru Jia Dawei Zhang Wolfgang Sand Fuhui Wang Tingyue Cu | 2018 | Journal of Materials Science & Technology2018,34,10: | 43 |
| 4 | 重症肌无力围手术期气管切开的危险因素探讨显示文摘目的 探讨重症肌无力(MG)病人胸腺切除术围手术期行气管切开的适应症和相关危险因素。方法 回顾性分析我院自1980年4月至1999年8月因MG行胸腺切除术病人174例,44例于围手术期行气管切开,占总数25.3%,38例发生危象,占总数21.8%。分析了重症肌无力临床分型、病期、是否伴有胸腺瘤、术前肺功能情况和术前抗胆碱能药物用量等因素与肌无力危象之间的关系及需要行气管切开术的手术适应症。结果 MG病人病程长、服用抗胆碱能药物剂量大、临床分期为Ⅱb型以上、术前有肺功能损害及合并有胸腺瘤者,特别是伴有侵润型胸腺瘤的患者,术后发生危象较高,需气管切开的比例也相应较高。结论 重症肌无力病人胸腺切除术后发生危象,及时气管切开,人工呼吸器辅助呼吸是降低病死率的重要措施;术后立即预防性气管切开术应根据患者的病情严格掌握,不能滥用,以有利于病人恢复。 | 赵云平 蒋耀光 王如文 马铮 ZHANG Xu-qing ZHANG Rui CU Chang-hai | 2001 | 第三军医大学学报2001,23,2: | 24 |
| 5 | Research and Application Prospect of Computer Simulation on Heat Treatment Process显示文摘In this paper, a modified temperature-phase transformation-stress/strain field coupled 3D non-linear mathematical model was used in the computer simulation on heat treatment processes of workpieces including catch jaw, anchor ring, cold roller, large-scale bearing roller, nitriding crank shaft, etc. The simulation on complicated technologies such as pre-cooled quenching, double media quenching, self-tempering, difference temperature heating, nitriding distortion was carried out. The optimum design of heat treatment technology has been realized. The successful application of computer simulation on heat treatment have also been demonstrated. | Pan Jiansheng, Li Yongjun, Cu Jianfeng, Hu Mingjuan Open Research Lab for High Temperature Materials & Testing, SJTU, Shanghai, 200030 | 2000 | Journal of Shanghai Jiaotong university(Science)2000,5,1: | 19 |
| 6 | 新型固定式宫内节育器与TCu220C的临床效果比较性研究显示文摘本文系研究新型固定式宫内节育器(Fix—CuU300IUD)的临床避孕效果、副反应和可接受性,选用目前公认较为理想的TCu220C作对照,采用多中心随机比较性研究。自1993年2月至5月共接收合格对象2104例(各1052例),1年随访率为99.95%。使用12个月结果表明:FIX-Cu300IUD累积妊娠率为0.09%,对照组为1.43%(P<0.01);脱落率分别为0.95%和2.28%(P<0.05);因症取出率依次为1.04%和2.09%(P>0.05);续用率分别为97.33%和93.82%(P<0.05)。98%以上受试者对所使用的Fix-Cu300IUD的避孕效果满意,证实此种IUD符合WHO的可接受性IUD标准。 | Wang Shuzhen,et al. Wu Han New Type Fix - Cu IUD ResearchGroup, 430030. | 1995 | 中国实用妇科与产科杂志1995,11,4: | 11 |
| 7 | 非典型抗精神病药物治疗住院精神分裂症或双相障碍患者急性激越和敌对的疗效:一项系统综述的结果(英文)显示文摘急性激越和敌对是双相障碍和精神分裂症患者的常见症状。本综述中,我们讨论在双相障碍或精神分裂症患者中上述症状的发生率、临床评估策略、治疗方案以及目前国内外针对这些症状的治疗指南。在现有的方法中,有使用肌肉注射的抗精神病药物和最近获得批准的口服非典型抗精神病药物治疗双相障碍或精神分裂症住院患者的急性激越和敌对,我们详细讨论了支持这些方法的最新证据,并强调各个抗精神病药物之间的一些差异。 | 于欣 CORRELL CU 项玉涛 徐一峰 黄继忠 杨甫德 王刚 司天梅 KANE JM MASAND P | 2016 | 上海精神医学2016,28,5: | 10 |
| 8 | 越南水稻生产及其迁飞性害虫发生情况显示文摘介绍了越南水稻生产及其迁飞性害虫与病毒病发生为害情况,分析了中国与越南水稻迁飞性害虫的发生虫源关系,并就进一步明确我国水稻迁飞性害虫的主要虫源地及对我国的影响、迁飞发生规律提出了在深化与越南合作基础上,扩大与老挝、缅甸、柬埔寨等虫源地国家加强合作研究的建议。 | 刘万才 陆明红 翟保平 王建强 高小丽 Hoang Anh Tuan Ho Dang Cu | 2014 | 中国植保导刊2014,34,10: | 9 |
| 9 | Stem cell therapy in the management of shoulder rotator cuff disorders显示文摘Rotator cuff tears are frequent shoulder problems that are usually dealt with surgical repair. Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. It is essential to understand the molecular mechanisms that determine this failure. The study of the molecular environment during embryogenesis and during normal healing after injury is key in devising strategies to get a successful repair. Mesenchymal stem cells(MSC) can differentiate into different mesodermal tissues and have a strong paracrine, anti-inflammatory, immunoregulatory and angiogenic potential. Stem cell therapy is thus a potentially effective therapy to enhance rotator cuff healing. Promising results have been reported with the use of autologous MSC of different origins in animal studies: they have shown to have better healing properties, increasing the amount of fibrocartilage formation and improving the orientation of fibrocartilage fibers with less immunologic response and reduced lymphocyte infiltration. All these changes lead to an increase in biomechanical strength. However, animal research is still inconclusive and more experimental studies are needed before human application. Future directions include expanded stem cell therapy in combination with growth factors or different scaffolds as well as new stem cell types and gene therapy. | Maria Valencia Mora Miguel A Ruiz Ibán Jorge Díaz Heredia Raul Barco Laakso Ricardo Cuéllar Mariano García Arranz | 2015 | World Journal of Stem Cells2015,7,4: | 6 |
| 10 | ACCF/SCAI/SVMB/SIR/ASIIN 2007年颈动脉支架置入术临床专家共识文件 美国心脏病学会基金会特别工作组关于临床专家共识文件的报告(ACCF/SCAI/SVMB/SIR/ASIIN颈动脉支架置人术临床专家共识文件委员会)与美国介入与治疗神经放射学学会、心血管造影和介入治疗学会、血管医学和生物学学会、介入放射学学会联合发布显示文摘本文件在美国心血管造影和介入治疗学会(Society for Cardiovascular Angiography and Interventions.SCAI)、血管医学和生物学学会(Society for Vascular Medicine and Biology,SVMB)、介入放射学学会(Society of Interventional Radiology,SIR)、美国介入与治疗神经放射学学会(American Society of Interventional &Therapeutic Neuroradiology,ASITN)共同倡导下,由美国心脏病学会基金会(American College of Cardiology Foundation,ACCF)临床专家共识文件(Clinical Expert Consensus Documents,CECD)特别工作组起草发布,旨在提供颈动脉支架置入术(carotid artery stenting,CAS)当前状况的全貌。 | Bates ER(著) Babb JD(著) Casey DE Jr(著) Cates CU(著) Duckwiler GR(著) Feldman TE(著) Gray WA(著) Ouriel K(著) Peterson ED(著) Rosenfield K(著) Rundback JH(著) Safian RD(著) Sloan MA(著) White CJ(著) 刘慧慧(译) 吴延华(译) 靳勇(译) 曹勇军(译) 刘春风(译) | 2007 | 中华脑血管病杂志(电子版)2007,1,3: | 4 |
| 11 | Umbilical hernia in patients with liver cirrhosis: A surgical challenge显示文摘Umbilical hernia occurs in 20% of the patients with liver cirrhosis complicated with ascites. Due to the enormous intraabdominal pressure secondary to the ascites, umbilical hernia in these patients has a tendency to enlarge rapidly and to complicate. The treatment of umbilical hernia in these patients is a surgical challenge. Ascites control is the mainstay to reduce hernia recurrence and postoperative complications, such as wound infection, evisceration, ascites drainage, and peritonitis. Intermittent paracentesis, temporary peritoneal dialysis catheter or transjugular intrahepatic portosystemic shunt may be necessary to control ascites. Hernia repair is indicated in patients in whom medical treatment is effective in controlling ascites. Patients who have a good perspective to be transplanted within 3-6 mo, herniorrhaphy should be performed during transplantation. Hernia repair with mesh is associated with lower recurrence rate, but with higher surgical site infection when compared to hernia correction with conventional fascial suture. There is no consensus on the best abdominal wall layer in which the mesh should be placed: Onlay, sublay, or underlay. Many studies have demonstrated several advantages of the laparoscopic umbilical herniorrhaphy in cirrhotic patients compared with open surgical treatment. | Julio CU Coelho Christiano MP Claus Antonio CL Campos Marco AR Costa Caroline Blum | 2016 | World Journal of Gastrointestinal Surgery2016,8,7: | 4 |
| 12 | Analysis of a Mesoscale Convective System that Produced a Single Sprite显示文摘Sprites are brief optical emissions occurring above thunderstorms. Features of sprites and their parent thunderstorms and lightning activities have been studied by many researchers. Here, we report a single sprite recorded over a mesoscale convective system during its life cycle in Northeast China. The results show that the sprite might have been a dancing one,with a 20 km horizontal displacement from its parent cloud-to-ground flash(CG) and a 38 ms time delay; all the sprite elements occurred during the continuing current process of the parent flash. The peak current of the parent CG was the largest during the almost one-hour time window containing the sprite, and the absolute values of all the negative flashes were smaller than 100 k A during the same time period and did not produce sprite. The sprite did not occur during the time period in which the maximum area of the thunderstorm reached. The occurrence of sprite corresponded well with the decay of the thunderstorm convection, and no significant relationship between the occurrence of sprite and the increase in the 30–35 d BZ and 35–40 d BZ interval was found. The large wind gradient in the 8–12 km region of the thunderstorm may have played an important role in the sprite production. | Jing YANG Gaopeng LU Ningyu LIU Haihua CU Yu WANG Morris COHEN | 2017 | Advances in Atmospheric Sciences2017,34,2: | 3 |
| 13 | Hybrid Endovascular Aorta Repair with Simultaneous Supra-aortic Branch or Iliac Branch Revascularization显示文摘Objective To describe a hybrid endovascular procedure for aorta repair with different kinds of bypass followed by concomitant placement of stent graft in the aorta. Methods From June 2007 to May 2008, 5 consecutive patients who presented with aortic aneurysm or dissection were treated with a new hybrid aorta repair technique. Complete surgical rerouting of supra-aortic vessels was simultaneously created by endovascular repair of aortic arch aneurysm with stent graft. Hybrid left carotid-subclavian bypass with stent graft deployment covering the ostium of the left subclavian artery was performed in a Debakey type III aortic dissection case. The supra-aortic branch was revascularized in 2 cases from ascending aorta to bilateral common carotid arteries using a 16-8 mm bifurcated graft, then total aortic arch and descending artery was occluded with stent-graft. The left carotid artery to the left subclavian artery bypass was created in 1 case, followed by stent-graft deployment. Two cases of infrarenal abdominal aortic aneurysm underwent left external iliac artery to left internal iliac artery bypass by a retroperineal route, then hybrid procedure was performed with bifurcated stent-graft. All stent grafts were deployed via a retrograde femoral artery approach in 5 patients. Results Technical success with complete aneurysmal exclusion was achieved in all patients. There was no incidence of endoleak. During a follow-up period of 2 to 10 months, documented perioperative neurologic events did not occur in all patients. One patient suffered from adult respiratory distress syndrome. After received tracheostomy, he recovered later. There was one death resulting from a postoperative myocardial infarction. Conclusion Hybrid arch repair provides an alternative therapy to patients otherwise considered prohibitively high risk for traditional open arch and thoracoabdominal aorta repair. | Yue-hong Zheng Nim Choi Hong-ru Deng CU Kouk Kun Yu Furtado Rui | 2009 | Chinese Medical Sciences Journal2009,24,3: | 3 |
| 14 | Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19^+ cells in Crohn's disease显示文摘AIM: To study anti-Epstein-Barr virus(EBV) Ig G antibodies in Crohn′s disease in relation to treatment, immune cells, and prior tonsillectomy/appendectomy.METHODS: This study included 36 CD patients and 36 healthy individuals(controls), and evaluated different clinical scenarios(new patient, remission and active disease), previous mucosa-associated lymphoid tissue removal(tonsillectomy and appendectomy) and therapeutic regimens(5-aminosalicylic acid, azathioprine, anti-tumor necrosis factor, antibiotics, and corticosteroids). T and B cells subsets in peripheral blood were analyzed by flow cytometry(markers included: CD45, CD4, CD8, CD3, CD19, CD56, CD2, CD3, TCRαβ and TCRγδ) to relate with the levels of anti-EBV Ig G antibodies, determined by enzyme-linked immunosorbent assay.RESULTS: The lowest anti-EBV Ig G levels were observed in the group of patients that were not in a specific treatment(95.4 ± 53.9 U/m L vs 131.5 ± 46.2 U/m L, P = 0.038). The patients that were treated with 5-aminosalicylic acid showed the highest anti-EBV Ig G values(144.3 U/m L vs 102.6 U/m L, P = 0.045). CD19+ cells had the largest decrease in the group of CD patients that received treatment(138.6 vs 223.9; P = 0.022). The analysis of anti-EBV Ig G with respect to the presence or absence of tonsillectomy showed the highest values in the tonsillectomy group of CD patients(169.2 ± 20.7 U/m L vs 106.1 ± 50.3 U/m L, P = 0.002). However, in the group of healthy controls, no differences were seen between those who had been tonsillectomized and subjects who had not been operated on(134.0 ± 52.5 U/m L vs 127.7 ± 48.1 U/m L, P = 0.523).CONCLUSION: High anti-EBV Ig G levels in CD are associated with 5-aminosalicylic acid treatment, tonsillectomy, and decrease of CD19+ cells. | Juan C Andreu-Ballester Rafael Gil-Borrás Carlos García-Ballesteros Ignacio Catalán-Serra Victoria Amigo Virgina Fernández-Fígares Carmen Cuéllar | 2015 | World Journal of Gastroenterology2015,21,15: | 3 |
| 15 | Prevalence of asymptomatic malaria parasitaemia显示文摘Objective:To evaluate factors associated with prevalence of malaria parasitaemia at first antenatal care visit.Methods:The study was conducted at the University of Calabar Teaching Hospital from 1st June,2007 to 31st July,2007.A structured questionnaire was administered to a total of 545 pregnant women that were recruited in this study after obtaining informed consent and two slides of thin and thick films were prepared for each participant.Results:Five hundred and twenty(95.4%) out of the 545 participants suffered from malaria parasitaemia,the rest 4.6%of those who had no parasitaemia had experienced symptomatic malaria before and were treated in private hospitals prior to their recruitment into the study.All participants(100%) who did not have antimalarials had parasitaemia compared with 91.1%among those that had antimalarials.The proportion of moderate to severe parasitaemia was also significantly higher among the former.Besides,the difference in parasitaemia between primigravidae and multigravidae was statistically significant(P=0.000) too. Among the methods used for vector control,only insecticide treated nets(ITNS) was associated with significant reduction in the level of parasitaemia(RR=0.83).Conclusion:Malaria parasitaemia at first booking is significandy higher in primigravidae and women who have no anti-malaria treatment. The use of safe and effective antimalarial treatment along with ITNs will significandy reduce the level of parasitaemia in pregnant women. | Agan TU Ekabua JE Iklaki CU Oyo-Ita A Ibanga I | 2010 | Asian Pacific Journal of Tropical Medicine2010,3,1: | 2 |
| 16 | Novel eco-efficient reactive distillation process for dimethyl carbonate production by indirect alcoholysis of urea显示文摘Dimethyl carbonate is an eco-friendly essential chemical that can be sustainably produced from CO_(2),which is available from carbon capture activities or can even be captured from the air.The rapid increase in dimethyl carbonate demand is driven by the fast growth of polycarbonates,solvent,pharmaceutical,and lithium-ion battery industries.Dimethyl carbonate can be produced from CO_(2)through various chemical pathways,but the most convenient route reported is the indirect alcoholysis of urea.Previous research used techniques such as heat integration and reactive distillation to reduce the energy use and costs,but the use of an excess of methanol in the trans-esterification step led to an energy intensive extractive distillation required to break the dimethyl carbonate-methanol azeotrope.This work shows that the production of dimethyl carbonate by indirect alcoholysis of urea can be improved by using an excess of propylene carbonate(instead of an excess of methanol),a neat feat that we showed it requires only 2.64 kW·h·kg^(-1) dimethyl carbonate in a reaction-separation-recycle process,and a reactive distillation column that effectively replaces two conventional distillation columns and the reactor for dimethyl carbonate synthesis.Therefore,less equipment is required,the methanol-dimethyl carbonate azeotrope does not need to be recycled,and the overall savings are higher.Moreover,we propose the use of a reactive distillation column in a heat integrated process to obtain high purity dimethyl carbonate(>99.8 wt-%).The energy requirement is reduced by heat integration to just 1.25 kW·h·kg^(-1) dimethyl carbonate,which is about 52%lower than the reaction-separation-recycle process.To benefit from the energy savings,the dynamics and control of the process are provided for10%changes in the nominal rate of 32 ktpy dimethyl carbonate,and for uncertainties in reaction kinetics. | Iulian Patrașcu Costin S.Bîldea Anton A.Kiss | 2022 | Frontiers of Chemical Science and Engineering2022,16,2: | 2 |
| 17 | Hematological parameters in high altitude residents:Tibetan natives versus Han migrants显示文摘Objective Aim of our study was to compare hematological parameters in Tibetan natives with those in Han migrants living on the Tibet plateau in order to determine the potential effects of age,gender,and ethnicity on hematological response to hypoxia.Methods Blood hemoglobin(Hb,g/dl),hematocrit(Hct,%),red blood cells(RBC,10~6/mm^3) were measured in 3 588 healthy Tibetan natives and 3 371 Han migrants ranging in age from 5 to 72 years,living at a mean altitudes of 2 664 m,3 813 m,4 525 m and 5 226 m.Results Hemoglobin(Hb) concentration analysis was made by multiple regression equations relating hemoglobin to altitude and age.For 2 093 Han males,Hb =9.612+ 0.001440xaltitude+ 0.06148 xage.For1 948 Tibetan males,Hb =12.202+ 0.000462xaltitude+ 0.02893 xage.For 1 278 Han females,Hb = 10.858+0.000939xaltitude+ 0.02632 xage.For 1 640 Tibetan females,Hb =11.402+ 0.000626xaltitude+ 0.00412 xage.Each of the four equations was statistically significant(P<0.001),and had variance(r2) of 0.86 or more,indicating that altitude and age accounted for at least 85%of the variation in hemoglobin levels.The coefficients for altitude and for age were higher(P<0.05) in Han males than in Tibetan males and higher(P<0.05)in Han females than in Tibetan females.The Tibetan postmenopausal females had higher Hb values than premenopausal females only presented at altitude above 4 000 m while this phenomenon was beginning at altitude of 2 664 m among Han females.Conclusion We conclude that gender and increasing age in Tibetans are associated with lower hemoglobin values than those in Han at high altitude,and we speculate that genetic factors seems to be important. | Tian-yi WU Feng-yun LIU Ling HU Chun-yin WEI Zhi-gang WANG Ouzhou-LOUBU Chao-ying CU Bianba Xue-bin QI Bing SU | 2014 | 中国应用生理学杂志2014,30,6: | 2 |
| 18 | Reactive Effect of Low Intensity He-Ne Laser upon Damaged Ultrastructure of Human Erythrocyte Membrane in Fenton System by Atomic Force Microscopy显示文摘发现 modulating 的机制有低紧张 He-Ne 激光行动的红血球的 deform 能力,我们在人的红血球的超微结构上学习了低紧张 He-Ne 激光的效果膜。红血球在暴露他们到低紧张 He-Ne 激光前从 aFenton 反应系统与自由激进分子一起被对待。损坏红血球膜的超微结构被原子力量显微镜学检验。结果证明红血球膜变得很不平,膜的表面上的分子在与自由激进分子一起对待以后集合了进不同大小尺寸的粒子。在非照耀的组和 He-Ne 激光比较分子的粒子的会众的度照耀( 9 mW 和 18 mW )组织,我们发现在激光的分子的粒子的平均尺寸照耀组在非照耀的组是比那小的,显示低紧张激光让了修理功能到红血球膜的损坏由自由激进分子生产了。 | Yanhong CU Zhouyi GUO Yanping ZHAO Ying ZHENG Yanfang QIAO Jiye CAI Songhao LIU | 2007 | Acta Biochimica et Biophysica Sinica2007,39,7: | 2 |
| 19 | Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains显示文摘 | Virginia Aragon Marta Cerdà-Cuéllar Lorenzo Fraile Mark Mombarg Miquel Nofrarías Alexandre Olvera Marina Sibila David Solanes Joaquim Segalés | 2009 | Veterinary Microbiology2009,,3: | 2 |
| 20 | Pulse pressure and mortality in older people显示文摘 | Glynn RJ Chae CU Guralnik JM | 2000 | Arch of Int Med2000,160,20: | 1 |