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| 1 | Watch and wait approach in rectal cancer:Current controversies and future directions显示文摘According to the main international clinical guidelines,the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery.However,doubts have been raised about the appropriate definition of clinical complete response(cCR)after neoadjuvant therapy and the role of surgery in patients who achieve a cCR.Surgical resection is associated with significant morbidity and decreased quality of life(QoL),which is especially relevant given the favourable prognosis in this patient subset. Accordingly, therehas been a growing interest in alternative approaches with less morbidity,including the organ-preserving watch and wait strategy, in which surgery isomitted in patients who have achieved a cCR. These patients are managed with aspecific follow-up protocol to ensure adequate cancer control, including the earlyidentification of recurrent disease. However, there are several open questionsabout this strategy, including patient selection, the clinical and radiologicalcriteria to accurately determine cCR, the duration of neoadjuvant treatment, therole of dose intensification (chemotherapy and/or radiotherapy), optimal followupprotocols, and the future perspectives of this approach. In the present review,we summarize the available evidence on the watch and wait strategy in thisclinical scenario, including ongoing clinical trials, QoL in these patients, and thecontroversies surrounding this treatment approach. | Fernando López-Campos Margarita Martín-Martín Roberto Fornell-Pérez Juan Carlos García-Pérez Javier Die-Trill Raquel Fuentes-Mateos Sergio López-Durán JoséDomínguez-Rullán Reyes Ferreiro AlejandroRiquelme-Oliveira Asunción Hervás-Morón Felipe Couñago | 2020 | World Journal of Gastroenterology2020，26，29： | 10 |
| 2 | Magnetic resonance imaging for prostate cancer before radical and salvage radiotherapy: What radiation oncologists need to know显示文摘External beam radiotherapy(EBRT) is one of the principal curative treatments for patients with prostate cancer(PCa). Risk group classification is based on prostate-specific antigen(PSA) level, Gleason score, and T-stage. After risk group determination, the treatment volume and dose are defined and androgen deprivation therapy is prescribed, if appropriate. Traditionally, imaging has played only a minor role in T-staging due to the low diagnostic accuracy of conventional imaging strategies such as transrectal ultrasound, computed tomography, and morphologic magnetic resonance imaging(MRI). As a result, a notable percentage of tumours are understaged, leading to inappropriate and imprecise EBRT. The development of multiparametric MRI(mp MRI), an imaging technique that combines morphologic studies with functional diffusion-weighted sequences and dynamic contrastenhanced imaging, has revolutionized the diagnosis and management of PCa. As a result, mpM RI is now used in staging PCa prior to EBRT, with possible implications for both risk group classification and treatment decisionmaking for EBRT. mpM RI is also being used in salvageradiotherapy(SRT), the treatment of choice for patients who develop biochemical recurrence after radical prostatectomy. In the clinical context of biochemical relapse, it is essential to accurately determine the site of recurrence-pelvic(local, nodal, or bone) or distant-in order to select the optimal therapeutic management approach. Studies have demonstrated the value of mpM RI in detecting local recurrences-even in patients with low PSA levels(0.3-0.5 ng/m L)-and in diagnosing bone and nodal metastasis. The main objective of this review is to update the role of mpM RI prior to radical EBRT or SRT. We also consider future directions for the use and development of MRI in the field of radiation oncology. | Felipe Cou?ago Gemma Sancho Violeta Catalá Diana Hernández Manuel Recio Sara Montemui?o Jhonathan Alejandro Hernández Antonio Maldonado Elia del Cerro | 2017 | World Journal of Clinical Oncology2017，8，4： | 4 |
| 3 | New standard in locally advanced rectal cancer显示文摘In the following review we intend to ascertain the optimal neoadjuvant therapy inpatients with locally advanced rectal cancer. In 2004, a study revealed thatchemoradiotherapy (CRT) resulted in better local control when performedpreoperatively rather than postoperatively, thus neoadjuvant treatment wasestablished as a standard treatment. Subsequently, the Polish study and the Trans-Tasman Radiation Oncology Group showed no statistically significant differencebetween concomitant CRT over 5 wk vs short-course radiotherapy (RT).Therefore, both were established as standard neoadjuvant treatments. Later, theStockholm III study demonstrated that short-course RT had a higher completepathological response than long-course RT. It also showed that a delay betweenRT and surgery presented fewer complications. This opened a window of time toprovide an early and effective systemic treatment to prevent distant metastases.Studies show that short-course RT plus oxaliplatin-based chemotherapy couldachieve this. When comparing this total neoadjuvant treatment (TNT) vsconcomitant CRT, the former showed greater complete pathological response andlower acute toxicity. Studies presented during 2020 have also shown the benefitsof TNT in terms of complete pathological response, as well as disease andmetastasis-free survival. Our review suggests that probably TNT should be thenew standard treatment for these patients. However, we will have to wait for thefull text publications of these studies to confirm this statement. | Sebastián Solé Ramón Baeza Carolina Gabler Felipe Couñago | 2020 | World Journal of Clinical Oncology2020，11，12： | 2 |
| 4 | GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma显示文摘Malignant pleural mesothelioma(MPM)is a rare tumor with poor prognosis and rising incidence.Palliative care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional involvement.Numerous therapeutic advances have been made in recent years,including the use of less aggressive surgical techniques associated with lower morbidity and mortality(e.g.,pleurectomy/decortication),technological advancements in the field of radiotherapy(intensity-modulated radiotherapy,image-guided radiotherapy,stereotactic body radiotherapy,proton therapy),and developments in systemic therapies(chemotherapy and immunotherapy).These improvements have had as yet only a modest effect on local control and survival.Advances in the management of MPM and standardization of care are hampered by the evidence to date,limited by high heterogeneity among studies and small sample sizes.In this clinical guideline prepared by the oncological group for the study of lung cancer of the Spanish Society of Radiation Oncology,we review clinical,histologic,and therapeutic aspects of MPM,with a particular focus on all aspects relating to radiotherapy,including the current evidence base,associations with chemotherapy and surgery,treatment volumes and planning,technological advances,and reradiation. | Javier Luna Andrea Bobo Joaquín José Cabrera-Rodriguez María Pagola Margarita Martín-Martín María Ángeles González Ruiz Miguel Montijano Aurora Rodríguez Lira Pelari-Mici Almudena Corbacho Marta Moreno Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，8： | 2 |
| 5 | Involvement of the ethylene-signalling pathway in sugar-induced tolerance to the herbicide atrazine in Arabidopsis thaliana seedlings显示文摘 | SULMON C GOUESBET G AMRANI A E COUE I | 2007 | Journal of Plant Physiology2007，164，8： | 1 |
| 6 | Litter decomposition, climate and liter quality显示文摘 | Marie-Madeleine Cou?teaux Pierre Bottner Bj?rn Berg | 1995 | Trends in Ecology & Evolution1995，，2： | 1 |
| 7 | Stem cells for the treatment of spinal cord injury显示文摘 | Cou tts M Keirstead HS | 2008 | Exp Neurol2008，209，2： | 1 |
| 8 | Porphyrin assemblies on DNA as studied by a resonance light - scattering techniques显示文摘 | Pasternack RF Bustamante C CoUings PJ | 1993 | J Am Chem Soc1993，115，： | 1 |
| 9 | Stereotactic body radiation therapy:A good dance partner of oligometastatic non-small cell lung cancer to the sound of SINDAS study显示文摘The European Organization for Research on Treatment of Cancer Research published a consensus statement to establish the key criteria to define oligometastatic disease(OMD).According to those criteria,all lesions(both primary and metastatic)should be amenable to radical intent treatment with acceptable toxicity.Several retrospective studies have shown that adding local ablative therapy to the treatment of OMD improves outcomes;however,due to the diverse selection criteria and treatment strategies used in those studies,it is difficult to compare directly results to draw definitive conclusions.In recent years,prospective phase II trials,such as the SABR-COMET and'Oligomez'trials,have shown that stereotactic body radiation therapy(SBRT)improves outcomes in patients with OMD.More recently,interim results of the randomised phase 3 SINDAS trial were reported at the annual meeting of the American Society of Clinical Oncology 2020 demonstrating that upfront SBRT added to systemic treatment with tyrosine kinase inhibitors yielded a significant benefit in both progression-free survival and overall survival in patients with epidermal growth factor receptor-mutant oligometastatic non-small cell lung cancer.In the present editorial,we review the definition and historical context of advanced non-small cell lung cancer with OMD.In addition,we review the scientific evidence for local ablative therapy and SBRT and discuss the results of recently published prospective studies.We also discuss in depth the results of the SINDAS study,including the strengths and weaknesses of the study and the barriers to extrapolating these results to routine clinical practice. | Xabier Mielgo-Rubio Javier Garde-Noguera Oscar Juan Felipe Couñago | 2020 | World Journal of Clinical Oncology2020，11，12： | 1 |
| 10 | A unique clonal JAK2 mutation leading to constitutive signalling cau ses polycythaemia vera显示文摘 | James C Ugo V Le Couédic JP | 2005 | Nature2005，434，7037： | 1 |
| 11 | Comparison of the effects of acid and base hydrolyses on hydroxy andcyclopropane fatty acids in bacteria显示文摘 | Lambert Miu Amrt Moss Cou Wen | 1983 | Journal of Clinical Microbiology1983，18，6： | 1 |
| 12 | Cognitive impaim/ent and intracranial calcification in chronic hypoparathyroidism 显示文摘 | Kowdley KV Cou Bl 0 ES | 1999 | Am J Med Sei1999，317，5： | 1 |
| 13 | A unique clonal JAK2 mutati on leading to constitutive signalling causes poly-cythemia vera显示文摘 | James C Ugo V Le Coué dic J P | | 0，，： | 1 |
| 14 | Neighborhood Filters and PDE's 显示文摘 | A Buades B CoU J Morel | 2005 | Technical Report2005，2005，： | 1 |
| 15 | Adult Wilms tumor review of 14 patients显示文摘 | Williams G Colbeck RA Couing NFC | 1992 | Br J Urol1992，73，： | 1 |
| 16 | Function in neonates: role of early nu- trition 显示文摘 | KELLY D COU'I3'S A G P | 2000 | Lives Prod Sci2000，66，2： | 1 |
| 17 | The national response plan;Health and human services the lead for emergency support func-tion显示文摘 | Couing MP Martinelli A’Lavin RP | 2005 | Disaster Manag Response2005，3，2： | 1 |
| 18 | Enhanced expansion and maturation of megakaryocytic progenitors by fibronectin显示文摘 | Han P Cou XH Story CJ | 2002 | Cytotherapy2002，4，3： | 1 |
| 19 | Rheumatoid arthritis,corticosteroid therapy and hip fracture显示文摘 | Coo Per C Cou Pland C Mitchell M | 1995 | Ann Rheum Dis1995，54，： | 1 |
| 20 | Resonance light scattering: a new technique for studying chromophore aggregation 显示文摘 | Pasternack R F CoUings P J | 1995 | Science1995，269，： | 1 |
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