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| 1 | Renin-angiotensin system in the pathogenesis of liver fibrosis显示文摘Hepatic fibrosis is considered a common response to many chronic hepatic injuries.It is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.In spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains obscure.The hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and synthesis.Among the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important role.Angiotensin(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver tissue.We briefly review the liver fibrosis process and current aspects of the RAS.This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis. | Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana Cristina Simoes e Silva | 2009 | World Journal of Gastroenterology2009，15，21： | 37 |
| 2 | Nutritional value of a partially defatted and a highly defatted black soldier fly larvae (Hermetia illucens L.) meal for broiler chickens: apparent nutrient digestibility,apparent metabolizable energy and apparent ileal amino acid digestibility显示文摘Background: The study aimed to determine the apparent total tract digestibility coefficients(ATTDC) of nutrients, the apparent metabolizable energy(AME and AMEn) and the amino acid(AA) apparent ileal digestibility coefficients(AIDC)of a partially defatted(BSFp) and a highly defatted(BSFh) black soldier fly larvae meal. The experimental diets were: a basal diet and two diets prepared by substituting 250 g/kg(w/w) of the basal diet with BSFp or BSFh, respectively.Results: Significant differences were found between BSFp and BSFh meals for ATTDC of the nutrients: BSFp resulted more digestible than BSFh, except for ATTDC of CP which did not differed between meals, while a statistical trend was observed for ATTDC of DM and EE. The AME and AMEn values were significantly(P < 0.05) different between the two BSF meals, with higher levels for BSFp(16.25 and 14.87 MJ/kg DM, respectively). The AIDC of the AA in BSFp ranged from 0.44 to 0.92, while in BSFh they ranged from 0.45 to 0.99. No significant differences were observed for the AA digestibility(0.77 and 0.80 for BSFp and BSFh, respectively), except for glutamic acid, proline and serine that were more digestible in the BSFh meal(P < 0.05).Conclusions: Defatted BSF meals can be considered as an excellent source of AME and digestible AA for broilers with a better efficient nutrient digestion. These considerations suggested the effective utilization of defatted BSF larvae meal in poultry feed formulation. | Achille Schiavone Michele De Marco Silvia Martínez Sihem Dabbou Manuela Renna Josefa Madrid Fuensanta Hernandez Luca Rotolo Pierluca Costa Francesco Gai Laura Gasco | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 27 |
| 3 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 4 | Deficit Irrigation as a Strategy to Save Water:Physiology and Potential Application to Horticulture显示文摘水是农业仍然是的世界范围、灌溉的一个逐渐地少见的资源这个资源的最大、很低效的用户之一。和为有另外的部门的水资源的一场增加的比赛的低潮使用效率(WUE )( 例如旅游或工业) 正在强迫栽培者采用更贤明地使用水的新灌溉和耕作惯例。在有干燥、热的气候的区域,滴灌溉,保护栽培主要由减少流量和土壤水分蒸发蒸腾损失总量损失改进了 WUE。然而,互补途径仍然被需要在灌溉农业增加 WUE。当增加的潜在的方法由允许庄稼承受温和的水应力没有或产量和质量的仅仅边缘的减少在农业浇积蓄,象弄干的调整赤字灌溉或部分根一样的赤字灌溉策略出现了。如同蔬菜趋于不在产量和质量由于损失处理那么好,葡萄藤和几果树庄稼似乎很好被使适应赤字灌溉,而是另外的庄稼。这篇论文瞄准由描述他们的使用的主要后果到不同庄稼(水果,蔬菜和观赏植物) 的营养生长,产量和质量提供园艺的赤字灌溉策略和他们的潜力的生理的基础的概述。 | J.Miguel Costa Maria F.Ortuo M.Manuela Chaves | 2007 | Journal of Integrative Plant Biology2007，49，10： | 24 |
| 5 | Microwave Synthesis of Large Few-Layer Graphene Sheets in Aqueous Solution of Ammonia显示文摘Few-layer graphene (FLG) sheets with sizes exceeding several micrometers have been synthesized by exfoliation of expanded graphite in aqueous solution of ammonia under microwave irradiation, with an overall yield approaching 8 wt.%. Transmission electron microscopy (in bright-field and dark-field modes) together with electron diffraction patterns and atomic force microscopy confirmed that this graphene material consisted mostly of mono-, bi- or few-layer graphene (less than ten layers). The high degree of surface reduction was confirmed by X-ray photoelectron and infrared spectroscopies. In addition, the high stability of the FLG in the liquid medium facilitates the deposition of the graphene material onto several substrates via low-cost solution-phase processing techniques, opening the way to subsequent applications of the material. | Izabela Janowska Kambiz Chizari Ovidiu Ersen Spyridon Zafeiratos Driss Soubane Victor Da Costa Virginie Speisser Christine Boeglin Matthieu Houllé Dominique Bégin Dominique Plee Marc-Jacques Ledoux Cuong Pham-Huu | 2010 | Nano Research2010，3，2： | 22 |
| 6 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 7 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 8 | Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation显示文摘Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people worldwide.Although diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under investigation.Neuroinflammation and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during diabetes.The present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3. | Henrique Rocha Mendonca Raul Carpi-Santos Karin da Costa Calaza Ana Maria Blanco Martinez | 2020 | Neural Regeneration Research2020，15，4： | 16 |
| 9 | Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy:A review of the literature and critical reappraisal of the implicated pathomechanism显示文摘Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the effi cacy of a recently reported (but not yet tested in large- scale studies) modifi cation, that is, PPPD with antecolic duodenojejunostomy. | Kosmas I Paraskevas Costas Avgerinos Costas Manes Dimitris Lytras Christos Dervenis | 2006 | World Journal of Gastroenterology2006，12，37： | 16 |
| 10 | The circulating non-coding RNA landscape for biomarker research: lessons and prospectsfrom cardiovascular diseases显示文摘人的染色体的弥漫的抄写为无数非编码的 RNA 分子(ncRNAs ) 的生产负责有规章的功能的他们的一些。在心血管的生物学的 ncRNAs 的枢轴的角色在最后十年被揭开了,从在心血管的开发和功能的 micro-RNAs 的参与的描述开始,并且作为心血管的疾病的 biomarkers 由传播 ncRNAs 的使用列在后面。人的非编码的 secretome 被几 RNA 种填写在身体液体传播并且能为诊断和结果预言被用作 biomarkers。在心血管的疾病,分泌了 ncRNAs 包括心肌的梗塞,心脏的失败,和 atrial 纤维性颤动被描述了为几个条件的 biomarkers。在传播之中, ncRNAs, micro-RNAs (miRNAs ) ,长 noncoding RNA (lncRNAs ) 和圆形的 RNA (circRNAs ) 在不同心血管的疾病作为 biomarkers 被建议了。与标准 biomarkers 比较, ncRNAs 的生物化学的性质为更好的稳定性和灵活存储提供样品,和增加的敏感和特性的条件。在这评论,我们把当前的趋势和 ncRNA secretome 部件的使用的未来前景描述为心血管的疾病的 biomarkers,包括与他们的分泌物机制和规章的行动联系的开的问题。 | Ewa STFPIEN Marina C COSTA Szczepan KURC Anna DROZDZ Nuno CORTEZ-DIAS Francisco J ENGUITA | 2018 | Acta Pharmacologica Sinica2018，39，7： | 14 |
| 11 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 12 | How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related?显示文摘AIM:To investigate the prevalence of gastroesophageal reflux disease(GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux(LPR).METHODS:Between May 2011 and October 2011,41 consecutive patients with laryngopharyngeal symptoms(LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors(PPIs) for at least 8 wk,and the therapeutic outcome was assessed through validated questionnaires(GERD impact scale,GIS;visual analogue scale,VAS).LPR diagnosis was performed by ear,nose and throat specialists using the reflux finding score(RFS) and reflux symptom index(RSI).After a 16-d wash-out from PPIs,all patients underwent an upper endoscopy,stationary esophageal manometry,24-h multichannel intraluminal impedance and pH(MII-pH) esophageal monitoring.A positive correlation between LPR diagnosis and GERD was supposed based on the presence of esophagitis(ERD),pathological acid exposure time(AET) in the absence of esophageal erosions(NERD),and a positive correlation between symptoms and refluxes(hypersensitive esophagus,HE).RESULTS:The male/female ratio was 0.52(14/27),the mean age ± SD was 51.5 ± 12.7 years,and the mean body mass index was 25.7 ± 3.4 kg/m 2.All subjects reported one or more LPS.Twenty-five out of 41 patients also had typical GERD symptoms(heartburn and/or regurgitation).The most frequent laryngoscopic findings were posterior laryngeal hyperemia(38/41),linear indentation in the medial edge of the vocal fold(31/41),vocal fold nodules(6/41) and diffuse infraglottic oedema(25/41).The GIS analysis showed that 10/41 patients reported symptom relief with PPI therapy(P < 0.05);conversely,23/41 did not report any clinical improvement.At the same time,the VAS analysis showed a significant reduction in typical GERD symptoms after PPI therapy(P < 0.001).A significant reduction in LPS symptoms.On the other hand,such result was not recorded for LPS.Esophagitis was detected in 2/41 patients,and ineffective esophageal motility was found in 3/41 patients.The MII-pH analysis showed an abnormal AET in 5/41 patients(2 ERD and 3 NERD);11/41 patients had a normal AET and a positive association between symptoms and refluxes(HE),and 25/41 patients had a normal AET and a negative association between symptoms and refluxes(no GERD patients).It is noteworthy that HE patients had a positive association with typical GERD-related symptoms.Gas refluxes were found more frequently in patients with globus(29.7 ± 3.6) and hoarseness(21.5 ± 7.4) than in patients with heartburn or regurgitation(7.8 ± 6.2).Gas refluxes were positively associated with extraesophageal symptoms(P < 0.05).Overall,no differences were found among the three groups of patients in terms of the frequency of laryngeal signs.The proximal reflux was abnormal in patients with ERD/NERD only.The differences observed by means of MII-pH analysis among the three subgroups of patients(ERD/NERD,HE,no GERD) were not demonstrated with the RSI and RFS.Moreover,only the number of gas refluxes was found to have a significant association with the RFS(P = 0.028 andP = 0.026,nominal and numerical correlation,respectively).CONCLUSION:MII-pH analysis confirmed GERD diagnosis in less than 40% of patients with previous diagnosis of LPR,most likely because of the low specificity of the laryngoscopic findings. | Nicola de Bortoli Andrea Nacci Edoardo Savarino Irene Martinucci Massimo Bellini Bruno Fattori Linda Ceccarelli Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Vincenzo Savarino Stefano Berrettini Santino Marchi | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 13 | Development of a hybrid photoacoustic and optical monitoring system for the study of laser ablation processes upon the removal of encrustation from stonework显示文摘In the context of this work,a prototype hybrid photoacoustic(PA)and optical system for the on-line monitoring of laser cleaning procedures is presented.The developed apparatus has enabled the detection of MHz frequency range acoustic waves generated during the laser ablation process.The intrinsically generated PA signals combined with high resolution optical images provide the opportunity to follow the cleaning process accurately and in real time.Technical mock-ups have been used to demonstrate the potential of this novel technique with emphasis given to applications that refer to the restoration of Cultural Heritage(CH)surfaces.Towards this purpose,the real time monitoring of the laser assisted removal of unwanted encrustation from stonework has been achieved using IR and UV wavelengths.This novel approach has allowed for the precise determination of the critical number of laser pulses required for the elimination of the encrustation layer,while highlighting the dominant ablation mechanisms according to the irradiation wavelength.The promising results obtained using the prototype hybrid PA and optical system can open up new perspectives in the monitoring of laser cleaning interventions,promoting an improved restoration outcome. | Athanasia Papanikolaou George JTserevelakis Kristalia Melessanaki Costas Fotakis Giannis Zacharakis Paraskevi Pouli | 2020 | Opto-Electronic Advances2020，3，2： | 11 |
| 14 | The Dynamic Pollen Tube Cytoskeleton: Live Cell Studies Using Actin-Binding and Microtubule- Binding Reporter Proteins显示文摘花粉试管在雌蕊以内伸长为授精把精子房间搬运到胚胎囊。生长专门在试管顶发生,显示花粉试管延伸一个很戏剧的极的房间生长过程。一个特点花粉试管特征它的细胞骨架,它精心地包括被组织并且动态肌动朊微细丝和微导管。花粉试管生长依赖于肌动朊细胞骨架;它的组织和规定被各种各样的途径广泛地检验了,包括荧光灯在实时房间标记肌动朊绑定蛋白质的蛋白质学习。用以前描述的 GFP-NtADF1 和 GFP-LlADF1,并且新肌动朊记者蛋白质 NtPLIM2b-GFP,我们重申占优势的肌动朊在伸长组织烟草和百合花粉试管,这长,沿着花粉试管胫的流的肌动朊电报,和包括更短的肌动朊电报的接近顶点的结构。肌动朊微细丝的接近顶点的收集经历动态变化,产生从 basket-shaped,的结构的外观或塑造漏斗,对一枚微妙的戒指像网孔。NtPLIM2b-GFP 为 Rho GTPases 与一个 guanine 核苷酸交换因素在联合被使用, AtROP-GEF1,说明这些肌动朊记者蛋白质的使用探索在极的细胞生长过程和它的肌动朊细胞骨架之间的连接。与肌动朊细胞骨架相反,微导管看起来不在在被子植物花粉试管支持极的房间生长过程起一个直接作用。从 Arabidopsis AtEB1 基于微导管结束绑定蛋白质使用微导管记者蛋白质, GFP-AtEB1,我们证明广泛的微导管在伸长联网改变动力学的度的花粉试管显示器。这些记者蛋白质提供万用的工具探索在极的花粉试管生长过程的主要结构、发信号的部件之间的功能的连接。 | Alice Y. Cheung Qiao-hong Duan Silvia Santos Costa Barend H.J. de Graaf Veronica S. DiStilio Jose Feijo Hen-Ming Wu | 2008 | Molecular Plant2008，1，4： | 10 |
| 15 | Elastic Aerogels of Cellulose Nanofibers@Metal–Organic Frameworks for Thermal Insulation and Fire Retardancy显示文摘Metal–organic frameworks(MOFs)with high microporosity and relatively high thermal stability are potential thermal insulation and flame-retardant materials.However,the difficulties in processing and shaping MOFs have largely hampered their applications in these areas.This study outlines the fabrication of hybrid CNF@MOF aerogels by a stepwise assembly approach involving the coating and cross-linking of cellulose nanofibers(CNFs)with continuous nanolayers of MOFs.The cross-linking gives the aerogels high mechanical strength but superelasticity(80%maximum recoverable strain,high specific compression modulus of^200 MPa cm3 g−1,and specific stress of^100 MPa cm3 g−1).The resultant lightweight aerogels have a cellular network structure and hierarchical porosity,which render the aerogels with relatively low thermal conductivity of^40 mW m−1 K−1.The hydrophobic,thermally stable MOF nanolayers wrapped around the CNFs result in good moisture resistance and fire retardancy.This study demonstrates that MOFs can be used as efficient thermal insulation and flame-retardant materials.It presents a pathway for the design of thermally insulating,superelastic fire-retardant nanocomposites based on MOFs and nanocellulose. | Shengyang Zhou Varvara Apostolopoulou‑Kalkavoura Marcus Vinicius Tavares da Costa Lennart Bergstrom Maria Stromme Chao Xu | 2020 | Nano-Micro Letters2020，12，1： | 10 |
| 16 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 17 | 能够固定碳的热带林业实践:综述和东南亚案例研究显示文摘为了完成对《气候框架公约》所承担的义务,发达国家开始寻找可供选择的成本低效率高的减少温室气体排放的方法。这就引起了对基于森林的碳平衡的关注。植树和林业实践能够用于主动地移走大气中的CO_2。通过保护措施或改进森林管理能够防止或减少目前现有森林向大气中释放碳的趋势。在本文中,我们记述了一系列用于这方面探索的业已开始的成平衡项目,并详细描述了一个涉及在马来西亚Sabah的退化林地上植树的项目。据估计,经过一个60年的轮伐期,这一项目将能平衡183Mg C/hm^2,平均为100Mg C/hm^2·a。 | Pedro Moura Costa 王效科 | 1996 | 人类环境杂志1996，25，4： | 9 |
| 18 | Polymer-coated nanoporous carbons for trace seawater uranium adsorption显示文摘Polymer-coated mesoporous carbon nanocomposites were prepared from the immobilization of acrylonitrile and acrylic acid copolymers with divinylbenzene as a crosslinker onto a mesoporous carbon framework.High surface areas were maintained after polymerization with accessible porosity.This functional nanocomposite was tested as an adsorbent for uranium from high salinity solutions.Uranium adsorption results have shown that the adsorption capacities are strongly influenced by the density of the amidoxime groups and the specific surface area. | YUE YanFeng SUN XiaoGuang MAYES Richard T. KIM Jungseung FULVIO Pasquale F. QIAO ZhenAn BROWN Suree TSOURIS Costas OYOLA Yatsandra DAI Sheng | 2013 | Science China Chemistry2013，56，11： | 9 |
| 19 | Endoscopic management of difficult common bile duct stones:Where are we now?A comprehensive review显示文摘Endoscopic management for difficult common bile duct(CBD)stones still presents a challenge for several reasons,including anatomic anomalies,patients’individual conditions and stone features.In recent years,variable methods have emerged that have attributed to higher stone removal success rates,reduced cost and lower adverse events.In this review,we outline a stepwise approach in CBD stone management.As first line therapy,endoscopic sphincterotomy and large balloon dilation are recommended,due to a 30%-50%reduction of the use of mechanical lithotripsy.On the other hand,cholangioscopy-assisted lithotripsy has been increasingly reported as an effective and safe alternative technique to mechanical lithotripsy but remains to be reserved in special settings due to limited large-scale evidence.As discussed,findings suggest that management needs to be tailored to the patient’s characteristics and anatomical conditions.Furthermore,we evaluate the management of CBD stones in various surgical altered anatomy(Billroth II,Roux-en-Y and Roux-en-Y gastric bypass).Moreover,we could conclude that cholangioscopy-assisted lithotripsy needs to be evaluated for primary use,rather than following a failed management option.In addition,we discuss the importance of dissecting other techniques,such as the primary use of interventional endoscopic ultrasound for the management of CBD stones when other techniques have failed.In conclusion,we recognize that endoscopic sphincterotomy and large balloon dilation,mechanical lithotripsy and intraductal lithotripsy substantiate an indication to the management of difficult CBD stones,but emerging techniques are in rapid evolution with encouraging results. | Alberto Tringali Deborah Costa Alessandro Fugazza Matteo Colombo Kareem Khalaf Alessandro Repici Andrea Anderloni | 2021 | World Journal of Gastroenterology2021，27，44： | 8 |
| 20 | Surgical treatment of ulcerative colitis in the biologic therapy era显示文摘Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field. | Alberto Biondi Marco Zoccali Stefano Costa Albert Troci Ettore Contessini-Avesani Alessandro Fichera | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
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