|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Privatization and Bank Performance in Developing Countries显示文摘 | Boubakri N Cosset J Fischer K Guedhami O | 2005 | Journal of Banking and Finance2005，，29： | 1 |
| 3 | Political Connections of Newly Privatized Firms 显示文摘 | Boubakri N Cosset J Saffar W | 2008 | Journal of Corporate Finance2008，，14： | 1 |
| 4 | Politi- cal Connections of Newly Privatized Firms 显示文摘 | BOUBAKR1 N COSSET J C SAFFAR W | 2008 | Jour- nal of Corporate Finance2008，14，5： | 1 |
| 5 | Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes显示文摘 | Bartosch B Dubuisson J Cosset F L | 2003 | J Exp Med2003，197，5： | 1 |
| 6 | The financial and operating performance of newly privatized firms:evidence from developing countries显示文摘 | Boubakri N Cosset J | 1998 | Journal of Finance1998，53，： | 1 |
| 7 | Radiation toxicity to the heart:physiopathology and clinical data显示文摘 | GIRAUD P COSSET J M | 2004 | Bull Cancer2004，91，： | 1 |
| 8 | Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes 显示文摘 | Bartosch B Dubuisson J Cosset F-L | 2003 | J Exp Meal2003，5，： | 1 |
| 9 | EGFR and EphA2are host factors for hepatitis C virus entry and possible targets for antiviral therapy显示文摘 | Lupberger J Zeisel M B Xiao F Thumann C Fofana I Zona L Davis C Mee C J Turek M Gorke S Royer C Fischer B Zahid M N Lavillette D Fresquet J Cosset F L Rothenberg S M Pietschmann T Patel A H Pessaux P Doffol M Raffelsbe-rger W Poch O McKeating J A Brino L Baumert T F | 2011 | Nat Med2011，17，5： | 1 |
| 10 | Infectious hepatitis C virus pseudo particles containing functional E1-E2 envelope protein complexes显示文摘 | Bartosch B Dubuisson J Cosset F L | 2003 | J Exp Med2003，197，： | 1 |
| 11 | The role of state and foreign owners in corporate risk-taking:evidence from privatization显示文摘 | BOUBKARI N COSSET J SAFFAK W | 2013 | Journal of Finance and Economics2013，108，3： | 1 |
| 12 | Political connections of newly privatized firms 显示文摘 | Boubakri N J C Cosset W Saffar | 2008 | Journal of Corporate Finance2008，14，5： | 1 |
| 13 | Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C 显示文摘 | Pestka JM Zeisel MB Blfser E Schiirmann P Bartosch B Cosset FL Patel All Meisel H Baumert J Viazov S Rispeter K Blum HE Roggendorf M Baumert TF | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 14 | The role of state and foreign owners in corporate risk-taking:Evidence from privatization 显示文摘 | BOUBAKRI N COSSET J C SAFFAR W | 2013 | Journal of Financial Economics2013，，108： | 1 |
| 15 | Political connections of newly privatized firms 显示文摘 | Bouhakri N Cosset J C Saffar W | 2008 | Journal of Corporate Finance2008，14，5： | 1 |
| 16 | Post Privation Corporate Governance : The Role of Ownership Structure and Investor Protection显示文摘 | BOUBAKRI N COSSET J GUEDHAMI O | 2005 | Journal of Financial Economics2005，76，2： | 1 |
| 17 | Chemoradiotherapy for localizde Non-Hodgkin's lymphoma显示文摘 | COSSET J M | 1998 | N Engl Med1998，339，： | 1 |
| 18 | The financial and operating performance of newly privatized firms: Evidence from developing countries显示文摘 | Narjess B Cosset J C | 1998 | Journal of Finance1998，53，3： | 1 |
| 19 | Liberalization, corporate governance and the performanee of privatized firms in developing countries显示文摘 | Bonbakri N Cosset J C Guedhami O | 2005 | Journal of Corporate Finance2005，11，5： | 1 |
| 20 | The financial and operating performance of newly privatized firms: evidence from developing countries 显示文摘 | Boubakri N Cosset J | 1998 | Journal of Finance1998，53，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员