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	题名	作者	年代	出处	被引量
1	CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE.	Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola	2015	World Journal of Gastroenterology2015，21，9：	2
2	First report of Aberia caffra and Quercus cerris as hosts of Inonotus rickii显示文摘	Annesi T Coppola R D Amico L	2005	Plant Disease2005，89，：	1
3	Immediately preoperative laparoscopic staging for gastric cancer显示文摘	Coppola R Persiani R	1996	Surg Endosc1996，10，：	1
4	Analysis of complications of endoscopic sphincterotomy for biliary stones in a consecutive series of 546 patients显示文摘	Coppola R Riccioni M E Ciletti S	1997	Surg Endosc1997，112，：	1
5	Decay and canker caused by Inonotus rickii spreading on more urban tree species显示文摘	Annesi T Coppola R Motta E	2003	Forest Pathology2003，33，：	1
6	Diagnostic and pathogenetic implications of colorectal carcinomas with muhidirectional differentia- tion:a report of 4 cases 显示文摘	Ouban A Nawab R A Coppola D	2002	Clin Colorectal Cancer2002，1，：	1
7	Characterization of micrococci and staphylococci isolated from soppressata molisana, a Southern Italy fermented sausage显示文摘	COPPOLA R LORIZZO M	1997	Food Microbiol1997，14，：	1
8	The use of diurnal vigi lance changes in the EEG to verify vigilance-enhancing effects of memantine in a chnica; pharmacological study 显示文摘	Schulz H Jobert M Coppola R	1996	Neuro psychobiology1996，33，1：	1
9	The attachment scriptrepresentation procedure in an Italian sample: associations with aduh attachment interview scales and with maternal sensitivity显示文摘	Coppola G Vaughn BE Cassibba R	2006	Attach Hum Dev2006，8，3：	1
10	Fermentative ability of alginate-prebiotic encapsulated LactobaciUus acidophilus and survival under simulated gastrointestinal conditions显示文摘	NAZZARO F FRATIANNI F COPPOLA R	2009	Journal of Functional Foods2009，1，3：	1
11	The ketonic diet in children, adolescents and young adults with refractory epilep- sy:an Italian multicentric experience 显示文摘	Coppola G Veggiotti P Cusmai R	2002	Epilepsy Res2002，48，3：	1
12	Pancreatic resection for periampullary cancer in elderly patients显示文摘	Magistrelli P Masetti R Coppola R	1988	Hepatogastroenterology1988，45，19：	1
13	Levetiracetam monotherapy for children and adolescents with benign rolandic seizures 显示文摘	A Verrotti G Coppola R Manco	2007	Seizure2007，16，：	1
14	Modeling of biomass devolatilization in a fluidized bed reator显示文摘	FELICE R D COPPOLA G RAPAGNA S JAND N	1999	Can J Chem Eng1999，77，2：	1
15	Behaviour of Laetobacillus rhamnosus strains in ass's milk显示文摘	Coppola R Salimei E Sueei M	2002	Annals of Microbiolog2002，52，：	1
16	Characterization of mi- eroeoeei and staphylococci isolated from soppressata molisan-a, a Southern Italy fermented sausage显示文摘	Coppola R Lorizzo M Saotta R	1997	Food Microbiology1997，，14：	1
17	Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia 显示文摘	Marfella R Esposito K Giunta R Coppola G De Angelis L Farzati B	2000	Circulation2000，101，19：	1
18	Characterization of micrococci and staphylococci isolated from soppressate molisana,a Southern Italy fermented sausage显示文摘	Coppola R Lorizzo M	1997	Food Microbiology1997，14，：	1
19	Cerebral morphometric abnormalities in Tourette's syndrome: a quantitative MRI study of monozygotic twins 显示文摘	Hyde TM Stacey ME Coppola R	1995	Neurology1995，45，6：	1
20	Characterization of Micrococci and Staphylococci isolated from soppressata molisame southern Italy fermented sausage显示文摘	Coppola R Lorizzo M Saotta R		0，，：	1

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