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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation显示文摘 | Cooke K R Hill G R Gerbitz A | 2000 | Transplantation2000，70，2： | 2 |
| 3 | Application of times-series analysis techniques for freeway incldent显示文摘 | Ahmed S A Cook A R | 1989 | Transportation Research1989，，2： | 1 |
| 4 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 5 | Assessment of management alternatives on a small agricultural watershed 显示文摘 | Mostaghimi S Park S W Cooke R A | 1997 | Water Research1997，31，8： | 1 |
| 6 | Fibroblast growth factor, epidermal growth factor, and platelet derived growth factor-BB stimulate proliferation of clonally derived porcine myogenic satellite cells显示文摘 | Doumit M E Cook D R Merkel R A | 1993 | J Cell Physiol1993，157，： | 1 |
| 7 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 8 | National Ignition Facility target design and fabrication显示文摘 | COOK R C KOZIOZIEMSKI B J NIKROO A | 2008 | Laser and Particle Beams2008，26，3： | 1 |
| 9 | Analysis of freeway traffic time- series data by using Box-Jenkins technique 显示文摘 | Ahmaed M S Cook A R | 1979 | Trans- portation Research Board1979，，722： | 1 |
| 10 | Effects of T-2 mycotoxin on gastrointestinal tissues : a review of in vivo and in vitro models 显示文摘 | WORRELL N R MALLETT A K COOK W M | 1989 | Environ Toxicol1989，18，1： | 1 |
| 11 | A methodology for the as- sessment of unconventional(continuous) resources with an ap- plication to the Greater Natural Buttes Gas Field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | Natural Resources Research2010，19，4： | 1 |
| 12 | The values of ternary quadratic forms at prime arguments显示文摘 | Cook R J Fox A | 2001 | Mathematika2001，48，： | 1 |
| 13 | A comparison of clustering dynamics in the british broadcasting and financial services industries显示文摘 | NARESH R PANDIT GARY A S COOK G M P SWANN | 2002 | Economics of Business2002，9，2： | 1 |
| 14 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 15 | Windows version of the ion trap simulation program ITSIM: A powerful heuristic and predictive tool in ion trap mass spectrometry显示文摘 | BUI H A COOKS R G | 1998 | Journal of Mass Spectrometry1998，33，4： | 1 |
| 16 | Three-dimensional seismic geomorphology of a deep-water slope-channel system:the Sequoia field, offshore west Nile Delta, Egypt显示文摘 | Cross N E Cunningham A Cook R J | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 17 | Isolation of Resistance Gene Candidates (RGCs) and characterization of an RGC cluster in cassava显示文摘 | Lopez C E Zuluaga A P Cooke R | 2003 | Molecular Genetics and Genomics2003，269，5： | 1 |
| 18 | Nuclear Level Densities in Intermediate and Heavy Nuclei显示文摘 | COOK J L FERGUSON H MUSGROVE A R D | 1967 | Australian Journal of Physics1967，20，： | 1 |
| 19 | Ethanol causes accelerated GI arrest in differentiating HL260 cells显示文摘 | COOK R T KEINER J A YEN A | 1990 | Alc Clin Exp Res1990，14，： | 1 |
| 20 | Bonded stress model for design of adhesive anchors 显示文摘 | Cook R A Dpeer G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
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