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| 1 | Risk of liver disease in methotrexate treated patients显示文摘Methotrexate is the first line drug treatment for anumber of rheumatic and non-rheumatic diseases. It is effective in controlling disease activity and preventing disease-related damage, and significantly cheaper than many alternatives. Use in rheumatoid arthritis infers a significant morbidity and mortality benefit. Methotrexate is generally well tolerated but can cause symptomatic adverse events. Multiple serious adverse events have been attributed to methotrexate, based largely on older reports using high or daily doses, and subsequent case reports and circumstantial evidence. The risk with modern dosing regimens: Lower doses, weekly schedules, and concomitant folic acid is less clear. Clarification and dissemination of the actual risk is crucial so appropriate judgements can be made for patients who may benefit from this treatment. Methotrexate has been associated with a range of liver related adverse events ranging from asymptomatic transaminase elevations to fibrosis and fatal hepatic necrosis. Concern over potential liver toxicity has resulted in treatment avoidance, cessation, or recommendations for investigations which may be costly, invasive and unwarranted. Modern laboratory monitoring of liver blood tests may also influence the risk of more serious complications. The majority of present day studies report an approximate doubling of the relative risk of elevated transaminases in methotrexate treated patients but no increased risk of symptomatic or severe liver related adverse events. In this article we will review the evidence around methotrexate and liver related adverse events. | Richard Conway John J Carey | 2017 | World Journal of Hepatology2017，9，26： | 5 |
| 2 | CT virtual simulation显示文摘 | Conway J Robinson M H | 1997 | Br J Radiol1997，70，： | 2 |
| 3 | 87Sr/86Sr,143Nd/144Nd and REEs in Silurian phosphatic fossils显示文摘 | Bertram C J Elderfield H Aldridge R J Conway Morris S | 1992 | Earth Planetary Science Letter1992，113，： | 2 |
| 4 | 健康无症状受试者与无腰椎手术史慢性腰背痛患者腰椎拉伸强度的比较显示文摘腰背痛(low back pain,LBP)在急性期可自行恢复,但有相当一部分患者发展为慢性腰背痛(chronic low back pain,CLBP)。腰伸肌肌肉组织功能失调被认为是腰背部损伤和疼痛的危险因素之一,在CLBP发展进程中扮演一定角色。 | Conway R Behennah J Fisher J 王万舜 夏虹 | 2018 | 中国骨科临床与基础研究杂志2018，10，3： | 2 |
| 5 | Head and backbone of the Early Cambrian vertebrate Haikouichthys显示文摘 | SHU D CONWAY M S HAN J | 2003 | Nature2003，421，： | 1 |
| 6 | Intestinal colonization potential of Turbot ( Scophthalmus maximus ) and Dab (Limanda limanda )-associated bacteria with inhibitory effects against Vibrio anguillarum 显示文摘 | OLSSON J C WESTERDAHL A CONWAY P | 1992 | Appl Environ Microbiol1992，58，2： | 1 |
| 7 | The role of intensity-modulated radiotherapy in the treatment of parotid tumors 显示文摘 | Bragg CM Conway J Robinson MH | 2002 | int J Radiat Oncol Biol Phys2002，52，3： | 1 |
| 8 | A lower bound on the average error of vector quantizer显示文摘 | Conway J H Sloane J N | 1985 | IEEE Transactions on Information Theory1985，31，1： | 1 |
| 9 | Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions显示文摘 | Conway EM Pollefeyt S Cornelissen J | 2000 | Blood2000，95，4： | 1 |
| 10 | A pipiscid-like fossil from the Lower Cambrian of South China显示文摘 | Shu D -G Conway Morris S Zhang X.-L Chen L Li Y. ttan J | | 0，，： | 1 |
| 11 | Evidence for inter-annual variability of the carbon cycle from the NOAA/CMDL global air sampling network 显示文摘 | Conway T J Tans P P Waterman L S | 1994 | Journal of Geophysical Research1994，99，22： | 1 |
| 12 | Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions显示文摘 | Conway EM Pollefeyt S Cornelissen J | 2000 | Blood2000，95，4： | 1 |
| 13 | Brief paradoxical sleep deprivation impairs reference, but not working memory in the radial arm maze task显示文摘 | Smith C T Conway J M Rose G M | 1998 | Neurobiol Learn Mem1998，69，2： | 1 |
| 14 | Automation of the LTV Steel Hennepin tandem cold mill显示文摘 | Carlton A J Conway G H Davies R G | 1992 | Iron and Steel Engineer1992，69，6： | 1 |
| 15 | Early amidation approach to 3- -2-indolinones 显示文摘 | Manley JM Kalman M J Conway BG | 2003 | J Org Chem2003，68，16： | 1 |
| 16 | Electrical impedance tomography for thermal monitoring of hyperthermia treatment an assessment using in vitro and in vivo measurements显示文摘 | Conway J | 1987 | Clin Phys Physiol Meas1987，，8： | 1 |
| 17 | Working Memory, Attention Control, and The N-Back Task: A Question of Construct Validity显示文摘 | KANE M J CONWAY A R MIURA T K | 2007 | J Exp Psychol Learn Mem Cogn2007，33，3： | 1 |
| 18 | WONCA研究论文摘要汇编——外周动脉疾病的初级保健筛查:一项横断面研究显示文摘背景外周动脉疾病(PAD)的早期识别和风险控制策略可以减缓疾病进程,并降低心血管疾病的死亡风险。然而,初级保健PAD筛查的可行性和重要性是不确定的。目的该项研究(PIPETTE研究—初级保健中的PAD:目标人群筛查和后续管理)旨在确定初级保健PAD筛查的价值。评估以下结果:PAD的患病率和由踝肱指数(ABI)定义的PAD(ABI≤0.9)与QRISK2定义的心血管疾病发生风险(≥20)的一致性。设计与场所本次横截面研究基于威尔士梅瑟蒂德菲尔的大型全科医学实践。方法共选取1 101例具有≥2个预先确定的心血管疾病风险因素且未患有心血管疾病或糖尿病的人群。对参与者进行ABI和QRISK2评估,并完成爱丁堡间接性跛行问卷调查。结果共计368例参与了研究(参与率=33%)。PAD的患病率为3%(12/368)。发现1个PAD患者所需的筛查人数为31例。通过细化研究人群,选取年龄≥50岁且有吸烟史的患者,将筛查人数降至14例,同时仍可识别出100%的PAD患者。PAD患者中,33%的患者自陈间歇性跛行导致的严重限制生活方式的症状使后续血管内介入治疗成为必要,但先前并未告知给他们的全科医生。QRISK2评分预测92%的PAD患者存在高危心血管疾病风险。结论较低的PAD发生率以及QRISK2和ABI在预测高危心血管疾病风险方面相差无几的事实表明常规PAD筛查可能是不合理的。相反,需要提高公众对PAD的认识。 | DAVIES J H RICHARDS J CONWAY K 本刊编辑部 | 2017 | 中国全科医学2017，20，9： | 1 |
| 19 | Intestinal colonization potential of turbot (Scophthalmus maximus) and dab (Limanda limanda) - associated bacteria with inhibitory effects against Vibrio anguillarum显示文摘 | Olsson J C Westerdahl A Conway P | 1992 | Applied and Environmental Microbiology1992，58，2： | 1 |
| 20 | Ion-selective optode membranes using 9-(4-diethylamino-2-octadecanoatestyryl)- acridine acidochromic dye显示文摘 | Conway S Twellmeyer J | 1999 | Anal Chim Acta1999，398，1： | 1 |
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