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| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 3 | Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95-2 显示文摘 | Cong L Gasser J Zhao J | 2007 | Endocr Relat Cancer2007，14，3： | 1 |
| 4 | Approaching human language with complex networks显示文摘 | Cong J Liu H | 2014 | Physics of Life Reviews2014，，4： | 1 |
| 5 | Synthesis and characteriza- tion of nitrogen-doped TiO2 nanophotocatalyst with high visible light activity显示文摘 | CONG Y ZHANG J L CHEN F | 2007 | Journal of Physical Chemistry C2007，111，19： | 1 |
| 6 | A Study on Rutting Prediction of Asphalt Pavement for Orthotropie Steel Bridge Decks显示文摘 | Cong L Yang J Zhu H R | 2009 | Journal of Testing and Evaluation2009，37，5： | 1 |
| 7 | Discovery from combinatorial heterogeneous catalysis:A new class of catalyst for ethane oxidative dehydrogenation at low temperatures显示文摘 | LIU Y M CONG P J ROBERT D D | 2003 | Appl Catal A2003，254，： | 1 |
| 8 | Acute inflammatory reaction following experimental intracerebral hemorrhage in rat显示文摘 | Cong C Hoff J T Keep R F | 2000 | Brain Res2000，871，1： | 1 |
| 9 | Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs 显示文摘 | N Porchet Nguyen Van Cong J Dufosse | 1991 | Biochem Biophys Res Commun1991，175，2： | 1 |
| 10 | Synthesis,Structure and Ferromagnetic Properties of Ni-Doped ZnO Nanoparticles 显示文摘 | Cong C J Hong J H Liu Q Y | 2006 | Solid State Commun2006，138，： | 1 |
| 11 | Dag-map: graph-based FPGA technology mapping for delay optimization 显示文摘 | Chen K C Cong J Ding Y | 1992 | IEEE Design & Test of Computers1992，9，3： | 1 |
| 12 | Co-ordinated control design of generator excitation and SVC for transient stability and voltage regulation enhancement of multi-machine power systems显示文摘 | Cong L Wang Y Hill D J | 2004 | International Journal of Robust and Nonlinear Control2004，14，10： | 1 |
| 13 | Novel Br nsted acidic ionic liquid as efficient and reusable catalyst system for esterification显示文摘 | Gui J Z Cong X H Liu D | 2004 | Catal Commun2004，5，： | 1 |
| 14 | Selective alkylation of phenol with tert-butyl alcohol catalyzed by brnsted acidic imidazolium salts显示文摘 | Gui J Z Ban H Y Cong X H | 2004 | J Mol Catal A:Chem2004，225，： | 1 |
| 15 | A protein knockdown strategy to study the function of beta -catenin in tumorgenesis显示文摘 | Cong F Zhang J Pao w | 2003 | BMC Mol Bio2003，58，2： | 1 |
| 16 | Effects of Temperature on The Ferromagnetism of Mn-Doped ZnO Nanoparticles and Mn-Related Raman Vibration显示文摘 | Cong C J Liao L Liu Q Y | 2006 | Nanotechnology2006，17，： | 1 |
| 17 | Caspase family proteases and apoptosis显示文摘 | Fan T J Han L H Cong R S | 2005 | Acta Biochim Biophys Sin2005，37，11： | 1 |
| 18 | A cutting force model for rotary ultrasonic machining of brittle materials Original Research Article 显示文摘 | Liu De Fu Cong W L Pei Z J | 2012 | International Journal of Machine Tools and Manufacture2012，52，1： | 1 |
| 19 | Kinetics of thermal decomposition of nickel oxalate dehydrate in air 显示文摘 | Zhan D Cong C J Diakite K | 2005 | Thermochim Acta2005，430，112： | 1 |
| 20 | Optimality study of logic synthesis for LUT-based FPGAs显示文摘 | Cong J Minkovich K | 2007 | IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems2007，26，2： | 1 |
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