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| 1 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 2 | Primary malignant lymphoid tum-ours of the intestinal tract,Report of 37 cases with a study of factors infl-uencing prognosis显示文摘 | Dawson I M Comes J S Morson B C | 1961 | Br J Surg1961，49，8： | 1 |
| 3 | Study of the synthesis of poly(4,4'- diphenylether-1,3,4-oxadiazole) in solutions of poly (phosphoric acid)显示文摘 | Comes D Borges C P Pinto J C | 2001 | Polymer2001，42，3： | 1 |
| 4 | Solubilities of oxygen and carbon dioxide in butyl methyl imidazolium tetrafluoroborate as a function of temperature and at pressures close to atmospheric pressure显示文摘 | Husson-Borg P Majer V Comes M F C | 2003 | J Chem Eng Data2003，48，3： | 1 |
| 5 | Polygenic inheritance of TS, stuttering, AI)HD, conduct, and oppositional defiant disorder:The additive and sublractive effect of the three dopaminergie genes - DRD2, DBH, and DATI 显示文摘 | Comings DE Wu H Chiu C | 1996 | Am J Med Genet1996，67，3： | 1 |
| 6 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 7 | Frequency,severity,and duration of rhinovirus infections in asthmatics and non-asthmatic individuals:a longitudinal cohog study显示文摘 | Come JM Marshall C Smith S | 2002 | Lancet2002，359，9309： | 1 |
| 8 | Snail and slug play distinct roles during breast carcinoma progression 显示文摘 | Come C Magnino F Biheau F | 2006 | C1in Cancer Res2006，12，18： | 1 |
| 9 | Distribution,movements and diet of macrocrustaceans on a Scottish sandy beach with particular reference to predation on juvenile fishes 显示文摘 | Ansell A D Comely C A Robb L | 1999 | Mar Ecol Prog Set1999，176，： | 1 |
| 10 | Snail and slug play distinct roles during breast carcinoma progression显示文摘 | COME C MAGNINO F BIBEAU F | 2006 | Clin Cancer Res2006，12，18： | 1 |
| 11 | Influence of C3 deficiency on atherosclerosis显示文摘 | Buono C Come CE Witztum JL | 2002 | Circulation2002，105，： | 1 |
| 12 | Severe outbreaks of tomato yellow leaf curl Serdinia virus in Calabria, Southern Italy显示文摘 | Crescenzi A Comes S Napoli C | 2004 | Commun Agric Appl Bio Sci2004，69，4： | 1 |
| 13 | Frequency,seventy, and dura- tion of rhinovirus infections in asthmatics and non-asthmatic individ- uals : a longitudinal cohort study 显示文摘 | Come J M Marshall C Smith S | 2002 | Lancet2002，359，9309： | 1 |
| 14 | CIP2A is associated with hu-man breast cancer aggressivity 显示文摘 | Come C Laine A Chanrion M | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 15 | Measurement of nondegenerate optical nonlinearity using a two-color single beam method显示文摘 | Ma H Comes A S I Araujo C B de | 1991 | Appl Phys Lett1991，59，： | 1 |
| 16 | Decrease in sunflower( Helianthus annum)seed viability caused by high temperatures as related to energy metabolism, membrane damage and lipid composition 显示文摘 | Corbineau F Gay-Mathieu C Vinel D Come D | 2002 | Physical Plant2002，116，： | 1 |
| 17 | Reflection Z-scan technique for measurements of optical properties surfaces显示文摘 | Petrov D V Comes A S I Araujo C B de | 1994 | App Phys Lett1994，65，： | 1 |
| 18 | Highly dispersed CoMoS phase on titania nanotubes as efficient HDS显示文摘 | Cortés-Jácome M A Escobar J Angeles Chávez C | 2008 | Catalysts Catalysis Today2008，130，1： | 1 |
| 19 | structural characteriza- tion and properties of water-soluble N-( γ-propanoyl-amino acid)-chitosans 显示文摘 | COMES P GOMES C A R BATISTA M K S | 2008 | Carbohydrate Polymers2008，71，1： | 1 |
| 20 | Attribute Selection with Fuzzy Decision Reducts 显示文摘 | Comelis C Jensen R Hurtado G | 2010 | Information Sci- ences2010，180，2： | 1 |
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