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| 1 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | Edible anti- microbial films based on chitosan matrix 显示文摘 | Coma V Martial-Gros A Garreau S | 2002 | Journal of Food Science2002，67，3： | 1 |
| 3 | Multiple risk factors in root survivorship:a 4-year study in concord grape显示文摘 | Anderson L J Comas L H Lakso A N | 2003 | New Phytologist2003，158，3： | 1 |
| 4 | Overexpression of FABP 7 in Down Syndrome Fetal Brain Is Associated with PKNOX1 Gene-dosage Imbalance 显示文摘 | Sanchez Font M F Bosch Comas A Marfany G | 2003 | Nuclei Acids Res2003，31，11： | 1 |
| 5 | Abnormal first-trimester ductus venosus blood flow:a marker of cardiac defects in fetuses with normal karyotype and nuchal translucency显示文摘 | Martinez JM Comas M Borrell A | 2010 | Ultrasound Obstet Gynecol2010，35，3： | 1 |
| 6 | Targeted deletion ofangiotensin II type 1A receptor does not protect mice fromprogressive nephropathy of overload proteinuria 显示文摘 | Beniqni A Coma D Zoja C | 2004 | J AmSoc Nephrol2004，15，10： | 1 |
| 7 | Early prenatal diagnosis of major cardiac anomalies in a high-risk population显示文摘 | Comas Gabriel C Galindo A Martinez JM | 2002 | PrenatDiagn2002，22，7： | 1 |
| 8 | Evolutionary trajectories of β-Lactamase CTX-M-1 cluster enzymes predicting antibiotic resistance 显示文摘 | Novais A Comas I Baquero F | 2010 | PloS Pathogens2010，6，10： | 1 |
| 9 | Adjunctive globe magnetic resonance imaging in the diagnosis of posteriorscleritis显示文摘 | Cordero Coma M Garcia Moran A Yilmaz T | 2011 | Can J Ophthalmol2011，46，4： | 1 |
| 10 | On modelling of anisotropicviscoelasticity for soft tissue simulation: numerical solutionand GPU execution显示文摘 | Taylor Z A Comas O Cheng M | 2009 | Medical Image Analysis2009，13，2： | 1 |
| 11 | Modeling a twin tube cavitating shock absorber显示文摘 | Alonso M Comas A | 2006 | Automobile Engineering2006，220，8： | 1 |
| 12 | The progression of circadian phase during light exposure in animals and humans 显示文摘 | BEERSMA D G COMAS M HUT R A | 2009 | J Biol Rhythms2009，24，2： | 1 |
| 13 | Lansoprazole-induced gynecomastia 显示文摘 | Comas A Salgueiro E Hidalgo A | 2000 | Med chin(Bare)2000，114，10： | 1 |
| 14 | Evolutionary Trajectories ofβ-lactamase CTX-M-1 cluster enzymes predicting antibiotic resistance显示文摘 | Novais A Comas I Baquero F | 2010 | PloS pathogens2010，6，10： | 1 |
| 15 | Processing biomass in conventional oil refineries: Production of high quality diesel by hydrotreating vegetable oils in heavy vacuum oil mixtures 显示文摘 | HUBER G W CONNOR P O COMA A | 2007 | Appl Catal A2007，329，1： | 1 |
| 16 | Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F 显示文摘 | Coma S Amin DN Shimizu A | 2010 | Cancer Res2010，70，9： | 1 |
| 17 | Metals and chlorinated hydrocarbons in surficial sediments of three Nile Delta lakes, Egypt显示文摘 | Saad M A H Me Comas S R Eisenreich S J | 1985 | Water Air and Soil Pollution1985，24，1： | 1 |
| 18 | Inter- and inlraradiologist vari- ability in the BI-RADS assessment and breast density categories for screening mammograms 显示文摘 | Redondo A Comas M Maci/t F | 2012 | Br J Radiol2012，85，1019： | 1 |
| 19 | Magnesium Sultate As a Vehicle for Nebulized Salbutamol in Acute Asthma显示文摘 | Nannini Li Jr Pendio J C Coma R A | 2000 | Am J Med2000，108，： | 1 |
| 20 | Primary treatment of urban wastewater显示文摘 | Coma J Jabbouri A Grasmick A | 1991 | Water Science and Technology1991，24，7： | 1 |
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