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| 1 | Gut epithelial barrier dysfunction in humanimmunodeficiency virus-hepatitis C virus coinfectedpatients:Influence on innate and acquired immunity显示文摘Even in cases where viral replication has been controlled by antiretroviral therapy for long periods of time, human immunodeficiency virus(HIV)-infected patients have several non-acquired immunodeficiency syndrome(AIDS) related co-morbidities, including liver disease, cardiovascular disease and neurocognitive decline, which have a clear impact on survival. It has been considered that persistent innate and acquired immune activation contributes to the pathogenesis of these non-AIDS related diseases. Immune activation has been related with several conditions, remarkably with the bacterial translocation related with the intestinal barrier damage by the HIV or by hepatitis C virus(HCV)-related liver cirrhosis. Consequently, increased morbidity and mortality must be expected in HIV-HCV coinfected patients. Disrupted gut barrier lead to an increased passage of microbial products and to an activation of the mucosal immune system and secretion of inflammatory mediators, which in turn might increase barrier dysfunction. In the present review, the intestinal barrier structure, measures of intestinal barrier dysfunction and the modifications of them in HIV monoinfection and in HIV-HCV coinfection will be considered. Both pathogenesis and the consequences for the progression of liver disease secondary to gut microbial fragment leakage and immune activation will be assessed. | Mercedes Márquez Clotilde Fernández Gutiérrez delÁlamo JoséAntonio Girón-González | 2016 | World Journal of Gastroenterology2016，22，4： | 7 |
| 2 | In vitro activity of C20-diterpenoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum显示文摘 | PATRICIA G CLOTILDE M ISABEL R G | 2005 | International Journal of Antimicrobial Agents2005，25，： | 1 |
| 3 | Dissolution of oxidised Co-Cu ores using hydrochloric acid in the pres- ence of ferrous chloride 显示文摘 | Clotilde Apua M Mulaba-Bafubiandi AF | 2011 | Hydrometallurgy2011，108，： | 1 |
| 4 | Comparison of ims platforms for detecting and recovering Escherichia coli O157 and Shigellaflexneri in foods显示文摘 | LAU H K CLOTILDE L M LIN A P | 2013 | Jala2013，18，2： | 1 |
| 5 | l -Alanyl- l -glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis显示文摘 | Clotilde Fuentes-Orozco Roberto Anaya-Prado Alejandro González-Ojeda Humberto Arenas-Márquez Carlos Cabrera-Pivaral Gabino Cervantes-Guevara Luis M Barrera-Zepeda | 2003 | Clinical Nutrition2003，，1： | 1 |
| 6 | Diterpe- noid Alkaloid derivatives as potential chemotherapeu- tic agents in american trypanosomiasis 显示文摘 | Patricia G Clotilde M Isabel R G | 2006 | Pharma- cology2006，76，： | 1 |
| 7 | In vitro activity of C20-diterpenoid alkaloid derivatives in promastigotes and intra-cellular amastigotes of Leishmania infantum显示文摘 | PATRICIA G CLOTILDE M ISABEL R G | 2005 | International Journal of Antimicrobial Agents2005，25，： | 1 |
| 8 | Trends in the heavy metal content (Cd, Pb, Zn) of river sediments in the drainage basin of smelting activities显示文摘 | Clotilde Bertin Alain C M Bourg | 1995 | Water Research1995，29，7： | 1 |
| 9 | Transformation of barrel medic (Medicago truncatula) by Agrobeeteruum tumefaeiens and regeneration via somatic embryogenesis of transgenic and plants with the Mt ENOD12 nodulin promoted fused to the gus reporter gene显示文摘 | Chabaud M Clotilde L Cornne M | 1996 | Plant Cell Report1996，15，： | 1 |
| 10 | Percutaneous image- guided radiofrequency ablation of liver tumors显示文摘 | Lencioni R Crocetti L Clotilde Della Pina M | 2009 | Abdominal Imaging2009，34，5： | 1 |
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