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357篇 您的检索式：作者名="CLAYTON T"

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	题名	作者	年代	出处	被引量
1	Diagnosis in bile acid-CoA:Amino acid N-acyltransferase deficiency显示文摘Cholate-CoA ligase(CCL) and bile acid-CoA:amino acid N-acyltransferase(BAAT) sequentially mediate bile-acid amidation.Defects can cause intrahepatic cholestasis.Distinction has required gene sequencing.We assessed potential clinical utility of immunostaining of liver for CCL and BAAT.Using commercially available antibodies against BAAT and CCL,we immunostained liver from an infant with jaundice,deficiency of amidated bile acids,and transcription-terminating mutation in BAAT.CCL was normally expressed.BAAT expression was not detected.Immunostaining may facilitate diagnosis in bileacid amidation defects.	Nedim Hadzi Laura N Bull Peter T Clayton AS Knisely	2012	World Journal of Gastroenterology2012，18，25：	3
2	Increased CD3 lymphocytes and inos :further evidence of an inflammatory response in irritable bowelsyndrome显示文摘	Osullivan M Clayton N Wong T	2000	Gut2000，47，3：	2
3	Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy.	Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun	2012	World Journal of Gastroenterology2012，18，10：	2
4	Oxygen isotope fractionation divalent metal carbonates显示文摘	O'Neil J R Clayton R N Mayada T K	1969	Chemistry Geophysics1969，51，：	1
5	Application of geostatistics to characterize leaf area index (LAI) from flux tower to landscape scales using a cyclic sampling design显示文摘	Burrows S N Gower S T Clayton M K	2005	Ecosystems2005，5，：	1
6	Clinical correlates and consequences of anemia in a broad spectrum of patients with heart failure: results of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program显示文摘	O'Meara E Clayton T McEntegart MB	2006	Circulation2006，113，7：	1
7	Time series modeling and maximum entropy显示文摘	T J Ulrych R W Clayton	1976	Phys Earth Planet Interiors1976，12，23：	1
8	Oxygen isotope exchange between quartz and water 显示文摘	Clayton R N O'Neil J R Mayeda T K	1972	Journal of Geophysical Research1972，77，：	1
9	The mechanism of galactosamine toxicity revisited;a metabonomic study显示文摘	COEN M HONG Y S CLAYTON T A		0，，：	1
10	Oxygen isotope exchange between quartz and water 显示文摘	Clayton R N O'Neil J R Mayeda T K	1972	Journal of Geophysical Research1972，77，：	1
11	Changes in stomatal behavior and guard cell cytosolic free calcium in response to oxidative stress 显示文摘	McAinsh M R Clayton H Mansfield T A	1996	Plant Physiology1996，111，：	1
12	Mohs micrographie surgery for cutaneous lymphadenoma 显示文摘	Hanlon A Clayton A Stasko T	2012	Dermatol Surg2012，38，9：	1
13	Pharmaco-metabonomic phenotyping and personalized drug treatment 显示文摘	Clayton T A Lindon J C Cloarec 0	2006	Nature2006，440，7087：	1
14	Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism显示文摘	Clayton T A Baker D Lindon J C	2009	Proceedings of the National Academy ofSciences2009，106，14：	1
15	Performance evaluation of a water resources system under varying climatic conditions: Reliability, Resilience, Vulnerability and beyond 显示文摘	Asefa T Clayton J Adams A	2014	Journal of Hydrology2014，，508：	1
16	LiDAR Optical Rugosi- ty of Coral Reefs in Biscayne National Park, Florida显示文摘	Brock J C Wright C W Clayton T D	2004	Coral Reefs2004，23，1：	1
17	Finite- difference time-domain analysis of lossy transmission lines 显示文摘	RODEN J A CLAYTON R P SMITH W T	1996	IEEE Transactions on Electromagnetic Compati- bility1996，38，1：	1
18	Staff perceptions of work quality of a neonatal intensive care unit before and after transition from an open bay to a private room design显示文摘	Smith T J Schoenbeek K Clayton S	2009	Work2009，33，2：	1
19	Oxygen isotope fractionation in divalent metal carbonates显示文摘	O'Neil J R Clayton R N Mayeda T K	1969	Journal of Chemical and Physics1969，51，：	1
20	Summary ofbeach replenishment experience on US east coastbarrier island 显示文摘	PILKEY O H CLAYTON T D	1989	Journal of Coastal Research1989，5，1：	1

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