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689篇 您的检索式:作者名="CLAYTON A"
    题名 作者 年代 出处 被引量
1基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson 2006英国医学杂志中文版2006,9,1:2
2Selective Regulation of ICAM-1 and RANTES Gene Expression after ICAM-1 Ligation on Human Renal Fibroblasts显示文摘 Stylianou E Clayton A 2003J Am Soc Nephrol2003,14,1:1
3Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritime显示文摘NELSON K E CLAYTON R A GILL S R 1999Nature1999,399,:1
4Human tumor-de- rived exosomes selectively impair lymphocyte responses to in- terleukin-2 显示文摘Clayton A Mitchell J P Court J 2007Cancer Res2007,67,15:1
5Identification of transcrip- tional regulatory elements in human mitochondrial DNA by linker substitution analysis显示文摘TOPPER J N CLAYTON D A 1989Mol Cell Biol1989,9,3:1
6Economic Value Added (EVA) :Its uses and limitations 显示文摘Peter C Brewer Cyan Chandra Clayton A Hock 1999SAM Advanced Management Journal1999,64,2:1
7S-process studies:exact evaluation of an exponential distribution of exposures显示文摘CLAYTON D D WARD R A 1974The Astrophysical Journal1974,193,:1
8Selective regulation of I-CAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts显示文摘Blaher R Stylianou E Clayton A 2003Am Soc Nephrol2003,14,1:1
9Mouse L cell mitoehondrial DNA molecules are selected randomly for replication throughout the cell cycle显示文摘Bogenhagen D Clayton D A 0,,04:1
10On the role of Cr in the passivity of stainless steel显示文摘BROOKS A R CLAYTON C R DOSS K 1986Journal of Electrochemical Society1986,,12:1
11Analysis of antigen presenting derived exosomes, based on immuno-magnetic isolation and flow cytometry显示文摘Clayton A Court J Navabi H 2001J Immunol Methods2001,247,12:1
12Functional and molecular characterisation of mammary side population cells 显示文摘Alvi A J Clayton H Joshi C 2003Breast Cancer Res2003,5,:1
13A statistical evaluation of animal and nutrional factors influencing concentrations of milk urea ni- trogen显示文摘Broderick G A Clayton M C 1997J Dairy Sci1997,80,:1
14Analysis of the role of 13 major fimbrial subunits in colonisation of the chicken intestines by Salmonella enterica serovar Enteritidis reveals a role for a novel locus 显示文摘Clayton D J Bowen A J Hulme S D 2008BMC Microbiol2008,8,:1
15Molecular genetic aspects of human mitochondrial disorders 显示文摘Larsson N G Clayton D A 1995Annu Rev Genet1995,29,:1
16Helicobacter pylori porCDAB andoorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases whichmediate electron transport to NADP显示文摘Nicky J Hughes Chris L Clayton Peter A Chalk 1998Journal of bacteriology1998,180,5:1
17Initiation and beyond:multiple functions of the human mitochondrial transcription machinery显示文摘Bonawitz N D Clayton D A Shadel G S 0,,06:1
18The mechanism of galactosamine toxicity revisited;a metabonomic study显示文摘COEN M HONG Y S CLAYTON T A 0,,:1
19Regulation of an amino acid transporter mRNA in Trypanosoma brucei显示文摘Robles A Clayton C 2008Mol Biochem Parasitol2008,157,1:1
20An integrated analysis of the safety and tolerability of desvenlafaxine compared with placebo in the treatment of major depressive disorder显示文摘Clayton A H Kornstein S G Rosas G 2009CNS Spectr2009,14,4:1
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