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| 1 | Exploiting Additive Manufacturing Infill in Topology Optimization for Improved Buckling Load显示文摘增材制造可实现优质多功能构件所具有的高度复杂几何构型的制备。可以直接制备内含多孔填充的结构部件是其独有特征的一个例证。现有的设计方法还难以充分利用这一设计自由度,直接获得类似结构的设计。本文将展示涂层方法 (coating approach)的拓扑优化方法来作为多孔填充构件的设计方法,所设计的构件具有显著改进的临界屈曲载荷,从而使得整体结构部件的稳定性增强。传统的柔顺性拓扑优化方法极少在数学模型中考虑构件的屈曲约束,稳定性要求通常要经过后续的校核与改进过程满足。这一后续过程往往只能获得次优设计。本文所展示的方法弥补了传统柔顺性拓扑优化模型中难以考虑构件屈曲约束的缺陷。利用涂层拓扑优化方法与传统柔顺性拓扑优化同时对经典的MBB梁进行设计,并采用熔丝增材制造技术对设计结果进行了制备。实验结果验证了涂层方法的数学模型的正确性。由于填充材料的性质,在相同条件下,涂层优化得到的多孔填充结构的屈曲载荷比传统优化得到的实体结构高四倍以上。 | Anders Clausen Niels Aage Ole Sigmund | 2016 | Engineering2016，2，2： | 9 |
| 2 | 用最小量冷却液法钻削航空铝-钛多层复合板显示文摘介绍了汉堡工业大学采用最小冷却液法钻削多种复合板的研究结果。研究表明,在钻削铝-钛多层复合板时,钻削钛板切屑的摩擦磨损作用,会导致铝板的孔呈喇叭形,孔径波动幅度和平均孔径值增大并可能超出允差。试验采用了最小量冷却液技术,所用的3种冷却液对钻削孔径影响不大。使用涂层刀具加工时,钻削孔径同进给速度呈正比。钻头顶角越大,铝板的孔径越大,但钛板的孔径不变。为保证加工孔径质量,采用退刀排屑和扩孔方式加工,减小刃带宽度,增大进给前角和使用阶梯钻头。 | 王成勇 Clausen Rolf Hanke Harald | 2002 | 机械工程学报2002，38，6： | 7 |
| 3 | Hepatitis C virus infection in the human immunodeficiency virus infected patient显示文摘Human immunodeficiency virus(HIV)and hepatitis C virus(HCV)share the same transmission routes;therefore,coinfection is frequent.An estimated 5-10 million individuals alone in the western world are infected with both viruses.The majority of people acquire HCV by injection drug use and,to a lesser extent,through blood transfusion and blood products.Recently,there has been an increase in HCV infections among men who have sex with men.In the context of effective antiretroviral treatment,liver-related deaths are now more common than Acquired Immune Deficiency Syndromerelated deaths among HIV-HCV coinfected individuals.Morbidity and mortality rates from chronic HCV infection will increase because the infection incidence peaked in the mid-1980s and because liver disease progresses slowly and is clinically silent to cirrhosis and end-stage-liver disease over a 15-20 year time period for 15%-20%of chronically infected individuals.HCV treatment has rapidly changed with the development of new direct-acting antiviral agents;therefore,cure rates have greatly improved because the new treatment regimens target different parts of the HCV life cycle.In this review,we focus on the epidemiology,diagnosis and the natural course of HCV as well as current and future strategies for HCV therapy in the context of HIV-HCV coinfection in the western world. | Louise Nygaard Clausen Lene Fogt Lundbo Thomas Benfield | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 4 | 德国公司环境报告评估显示文摘994年进行了德国公司环境报告的第一次排名.1995年和1998年又进行了两次排名,以确定环境报告和陈述的数目已增加的程度,及其质量是否有所改善.基于所使用的基准,已经显示公司报告的质量有颇大差异.虽然总体质量有了改善。 | Jens Clausen Klaus Fichter | 1999 | 产业与环境1999，21，1： | 3 |
| 5 | Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta‐analysis of the LEAD program显示文摘 | M. J. Armstrong D. D. Houlihan I. A. Rowe W. H. O. Clausen B. Elbr?nd S. C. L. Gough J. W. Tomlinson P. N. Newsome | 2012 | Aliment Pharmacol Ther2012，，2： | 2 |
| 6 | Combination of the peaks - over - threshold and bootstrapping methods for extreme value prediction 显示文摘 | Naess A Clausen P H | 2001 | Structural Safety2001，23，4： | 2 |
| 7 | The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue 显示文摘 | XIE X CLAUSEN O P DE ANGELIS P | 1999 | Cancer1999，86，6： | 1 |
| 8 | Oxygen Consumption in freshwater fishes 显示文摘 | CLAUSEN R G | 1963 | Ecology1963，17，： | 1 |
| 9 | Sperm quality assessed by flow cytometry and accessory sex gland function in spinal cord injured men after repeated vibration-induced ejaculation显示文摘 | Clausen OP Purvis K | 1993 | Paraplegia1993，31，1： | 1 |
| 10 | Direct compressible polymethacry-lic acid-starch compositions for site specific drug delivery显示文摘 | Bernkop-Schnurch A | 2001 | J Control Release2001，75，1： | 1 |
| 11 | Enhanced the activity and development of chronic enterocolitis in mice devoid of state in macrophages and neutrophils 显示文摘 | Takeda K Clausen BE Kaisho T | 1999 | Immunity1999，10，1： | 1 |
| 12 | HIF-lalpha is essential for myeloid cell-mediated inflammation 显示文摘 | Cramer T Yamanishi Y Clausen BE | 2003 | Cell2003，113，3： | 1 |
| 13 | Evidence for general instability of past climate from a 250 kyr ice-core record显示文摘 | Dansgaard W Johnsen S J Clausen H B | 1993 | Nature1993，364，： | 1 |
| 14 | Evidence for general instability of past climate from a 250-kyr ice-core record显示文摘 | Dansgaard W Johnsen S J Clausen H B | 1993 | Nature1993，364，： | 1 |
| 15 | Na^+-K^+ Pump regulation and skeletal muscle contractility显示文摘 | CLAUSEN T | 2003 | Physiol Rev2003，83，： | 1 |
| 16 | Oxygen consumption in freshwater fishes显示文摘 | Clausen R G | 1936 | Ecology1936，17，2： | 1 |
| 17 | Oxygen consumption in freshwater fishes显示文摘 | Clausen RG | 1936 | Ecology1936，17，2： | 1 |
| 18 | Prognostic value of Le (y) and H antigen in oral tongue cancinomas 显示文摘 | Xie X Boysen M Clausen O P | 1999 | Laryngoscope1999，109，9： | 1 |
| 19 | Effects of deneration on sodi- um, potassium and ouabain binding in muscles of normal and potassium-depleted rats显示文摘 | Clausen T Kjeldsen K Norgaard A | 1983 | J Physiol1983，345，： | 1 |
| 20 | Epicardial border zone over-expression of skeletal muscle sodium channel SkMl normalizes acti-vation, preserves conduction, and suppresses ventricular arrhythmia:an in silico,in vivo, in vitro study显示文摘 | Lau DH Clausen C Sosunov EA | 2009 | Circulation2009，119，： | 1 |
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