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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Comparison of in vivo and in vitro efficacy of ceftizoxime 显示文摘 | Delaney M L Cisneros R L | 1990 | Clin Ther1990，12，： | 2 |
| 3 | Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast显示文摘 | Ramos C Montano M Cisneros J | 2007 | Exp Lung Res2007，33，34： | 1 |
| 4 | Bacteremia due to Acietobacter baumannii:epidemiology,clinical findings and prognostic features显示文摘 | Cisneros JM Reyes M J Pachon J | 1996 | Clin Infect Dis1996，22，： | 1 |
| 5 | Multifractal Hurst analysis of crude oil prices显示文摘 | Alvarez - Ramirea J Cisneros M Ibarra - Valdez C Soriano Z | 2002 | Physica A2002，313，： | 1 |
| 6 | Bacteremia due to Acinetobacter baumannii: Epidemiology, clinical findings: and prognostic features显示文摘 | Cisneros J M Reyes M J Pachon J etal | 1996 | Clin Infect Dis1996，22，6： | 1 |
| 7 | Synthesis of novel highly reactive silicone-epoxy mono- mers for cationic photopolymerizations 显示文摘 | ORTIZ R A de LOURDES GUILLIN CISNEROS M GARCIA G A | 2005 | Polymer2005，46，10： | 1 |
| 8 | Sorption of americium in tuff and pure minerals using synthetic and natural groundwaters显示文摘 | TRIAY I R MEIJER A CISNEROS M R | 1991 | Radiochimica Acta1991，5253，： | 1 |
| 9 | Matrix metalloproteinasesinhibition attenuates tobacco smoke - induced emphysema in guinea pigs 显示文摘 | Selman M Cisneros - Lira J Gaxiola M Ramirez R Kudlacz E M Mitchell P G Pardo A | 2003 | Chest2003，123，5： | 1 |
| 10 | Malondial dehyde and superoxide dismutase correlate with FEV( 1 ) in pa tients with COPD associated with wood smoke exposure and tobacco smoking 显示文摘 | Montafio M Cisneros J Ramirez Venegas A | 2010 | Inhalat Toxicol2010，22，10： | 1 |
| 11 | Hyperthermia inhibits recombi- nation repair of gemcitabine-stalled replication forks显示文摘 | Raoof M Zhu C Cisneros BT | 2014 | J Natl Cancer Inst2014，106，8： | 1 |
| 12 | Recovery in aqueous two-phase systems of lutein produced by the green microalga Chlorella protothecoides显示文摘 | Cisneros M Benavides J Brenes CH | 2004 | J Chromatogr B Analyt Technol Biomed Life Sci2004，807，1： | 1 |
| 13 | Quantitative pp65 antigenemia in the diagnosis of cytomegalovirus disease:prospective assessment in a cohort of solid organ transplant recipients显示文摘 | Bernabeu-Wittel M Pachón-Ib(a)(n)ez J Cisneros JM | 2005 | J Infect2005，51，3： | 1 |
| 14 | Receptor for advanced glycation end products is upregulated in optic neumpathy of Alzheimer's disease 显示文摘 | WANG M Y ROSS- CISNEROS F N AGGARWAL D | 2009 | Acta Neuro- patho12009，118，3： | 1 |
| 15 | Mulitifractal Hurst analysis of crude oil prices显示文摘 | Alvarez-Ramirez J Cisneros M Ibarra-Valdez C | 2002 | Physica A2002，313，： | 1 |
| 16 | Multifractal Hurst Analysis of Crude Oil Prices 显示文摘 | Alvarez-Ramirez J Cisneros M Ibarra-Valdz C Soriano A | 2002 | Physica A2002，313，： | 1 |
| 17 | Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase Ⅱ activity in rat limbic regions 显示文摘 | de Gortari P Cisneros M Joseph-Bravo P | 2005 | Regul Pept2005，127，13： | 1 |
| 18 | Grain Size Effects on the SCC Susceptibility of a Nitrogen Steel in Hot NaCl Solutions 显示文摘 | Opez H F L Cisneros M M Mancha H | 2006 | Corrosion Science2006，，48： | 1 |
| 19 | clinical features and epidemiology of Acinetobacter baumannii colo nization and infection in Spanish hospitals 显示文摘 | Rodrguez - Bano J Cisneros J M Fernandez - cuenca F | 2004 | Infect control hosp epidemiol2004，25，10： | 1 |
| 20 | Influence of Slaughter Weight on Growth and Carcass Characteristics,Commercial Cutting and Curing Yields,and Meat Quality of Barrows and Gilts from Two Genotypes显示文摘 | Cisneros F Ellis M McKeith F K | 1996 | J Anim Sci1996，74，： | 1 |
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