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| 1 | syndecan-1和-2表达形式的变化可以预测前列腺癌生化复发显示文摘前列腺癌的临床特点不能准确确定患者是否会发生生化复发,因而不适合作为预后和复发的指标。需要新的分子标记物对患者进行适当的术前风险分层。本研究旨在评估syndecan-1和-2的表达改变是否可以预测临床局限性前列腺癌患者行前列腺根治术后的生化复发。取60份局限性前列腺癌患者的石蜡包埋组织标本,采用免疫组化染色检测syndecan-1和-2的表达。取10份良性前列腺增生患者的样本作为非恶性对照。利用半定量分析,对其进行染色评估。为探讨预后效果,用Kaplan—Meier生存曲线进行分析,并进行log—rank检验。在良性前列腺样本中,syndecan-1在基底层上皮细胞中有表达,在上皮分泌细胞的基侧膜上也有表达;syndecan-2则主要但挞底层上皮细胞中表达。前列腺癌样本中,两种syndecan的表达模式都转变成定位在颗粒状细胞质上。生存分析显示,在游离前列腺特异性抗原(fPSA)复发存活曲线中,正常和改变的syndecan-1和-2的表达存在显著差异(P〈0.05)。这些数据表明,syndecan—1和-2可以作为临床局灶性前列腺癌患者预后的标记物,从而改进前列腺特异性抗原(PSA)评估复发风险,增加风险分层。 | Rodrigo Ledezma Federico Cifuentes Ivan Gallegos Juan Fulla Enrique Ossandon Enrique A Castellon Hector R Contreras | 2011 | Asian Journal of Andrology2011，13，3： | 2 |
| 2 | Use of compressed fluids for sample preparation:Food applications显示文摘 | MENDIOLA J A HERRERO M CIFUENTES A IBANEZ E | 2007 | J Chromatogr:A2007，1152，12： | 1 |
| 3 | Supercritical fluid extraction: Recent advances and applications显示文摘 | HERREROA M MENDIOLA J A CIFUENTES A | 2010 | J Chromatogr A2010，1217，16： | 1 |
| 4 | Optimization of biomass, total carotcnoids and astaxanthin production in Haematococcus pluvialis Flotow strain Steptoe ( Nevada, USA ) under laboratory conditions 显示文摘 | Cifuentes A S Gonzalez M A | 2003 | Biol Res2003，36，： | 1 |
| 5 | Determination of the isotopic composition ofammonium-nitrogen at the natural abundance level fromestuarine waters 显示文摘 | Velinsky D J Pennock J R Sharp J H Cifuentes L A Fogel M L | 1989 | Marine Chemistry1989，26，： | 1 |
| 6 | Stable carbon iso- topes evidence for coupling between sedimentary bacteria and sea-grasses in a sub-tropical lagoon 显示文摘 | JONES W B CIFUENTES L A KALDY J E | 2003 | Mar Ecol Prog Ser2003，255，： | 1 |
| 7 | Recent advances in the application of capillary electromigratioB methods for food analysis显示文摘 | GARCIA-CANAS V CIFUENTES A | 2008 | Electrophoresis2008，29，1： | 1 |
| 8 | Isotopic and elemental variations of carbon and nitrogen in a mangrove estuary显示文摘 | CIFUENTES L A COFFIN R B SOLORZANO L | 1996 | Estuarine Coastal and Shelf Science1996，43，： | 1 |
| 9 | Green processes based on the extraction with pressurized fluids to obtain potent antimicrobials from Haematococcus pluvialis microalgae显示文摘 | Santoyo S Rodríguez-Meizoso I Cifuentes A | 2009 | Lwt Food Science and Technology2009，42，7： | 1 |
| 10 | Use of compressed fluids for samplepreparation: Food applications 显示文摘 | Mendiola J A Herrero M Cifuentes A | 2007 | Journal of Chromatography A2007，1152，12： | 1 |
| 11 | Sub and supercritical fluid extraction of functional ingredients from different natural sources:plants,food-by-products,algae and mi-croalgae:a review显示文摘 | Herrero M Cifuentes A Ibanez E | 2006 | Food Chem2006，98，1： | 1 |
| 12 | The binomial expectation method applied to CBO/CLO analysis显示文摘 | Cifuentes A Connor G | 1996 | Moody'' s Special Report1996，，： | 1 |
| 13 | Simultaneous and sensitive detection of three-foodbome pathogen by multiplex PCR, capillary gel electrophoresis, and laser-induced fluores- cence 显示文摘 | Alarcon B Garcia-Canas V Cifuentes A | 2004 | J Agric Food Chem2004，52，： | 1 |
| 14 | Utilization of DOC from seagrass rhizomes by sediment bacteria: ^13C-tracerexperiments and modeling显示文摘 | Kaldy J E Eldridge P M Cifuentes L A | 2006 | Marine Ecology Progress Seri- es2006，317，： | 1 |
| 15 | Sodium Isopropyl Xanthate Degradation by Advanced Oxidation Processes显示文摘 | Gerardo Cifuentes Molina Cármen Herrera Cayo Marco Ant?nio Siqueira Rodrigues Andréa Moura Bernardes | 2012 | Minerals Engineering2012，，： | 1 |
| 16 | Anaerobic methane oxidation in a landfill-leachate plume显示文摘 | Grossman E L Cifuentes L A Cozzarelli I M | 2002 | Environment Science and Technology2002，36，11： | 1 |
| 17 | Pressurized liquids as an alternative process to antioxidant carotenoids'extraction from Haematococcus pluvialis microalgae显示文摘 | Jaime L Rodríguez-Meizoso I Cifuentes A | 2010 | Lwt Food Science and Technology2010，43，： | 1 |
| 18 | A performance study of tetrahedral and hexahedral elements in 3-D finite element analysis显示文摘 | Cifuentes A O Kalbag A | 1992 | Finite ELements in Analysis and Design1992，12，34： | 1 |
| 19 | Physical and functional interation of androgen recepor with calmodulin in prostate cancercells显示文摘 | Cifuentes E Mataraza J M Yoshida B A | 2004 | Proc Natl Acad Sci USA2004，101，2： | 1 |
| 20 | Ultrasensitive detection of genetically modified maize DNA by capillary gel electrophoresis with laster-induced fluorescence using different fluorescent intercalating dyes显示文摘 | GARCIA-CANAS V GONZALEZ R CIFUENTES A | 2002 | J Agric Food Chem2002，50，16： | 1 |
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