| 1 | Paleoproterozoic granitic gneisses of the Dinggye and LhagoiKangri areas from the higher and northern Himalaya,Tibet:Geochronology and implications显示文摘Granitic gneisses have been widely found in crystalline rocks in the Dinggye area of the Higher Himalaya (HHM) and the LhagoiKangri area of the North Himalaya (NHM), Tibet. In the HHM, the gneisses intruded in the granulite-amphibolite facies metamorphosed sedimentary rocks, known as Nyalam group. In the NHM, the gneisses intruded in the amphibolite facies metamorphosed ones, known as LhagoiKangri group. These granitic gneisses are peraluminous monzonitic granites in terms of their mineral assemblage, and are considered as being derived from metamorphosed sedimentary rocks by anatexis based on the transitional relationship of the gneisses with their migmatitized wall rocks. Zircons are similar in crystal shape and interior structure from both gneisses. Most of them are euhedral or subhedral elongated prism-shaped transparent crystals, with fine oscillatory zoning, showing the magmatic genesis. Some of them are short prism-shaped and with relict core inherited from magma source and oscillatory zoning mantle crystallized from magma. SHRIMP U-Pb dating of zicons shows that both the granitic gneisses in the HHM and NHM are Paleoproterozoic (1811.6±2.9 Ma and 1811.7±7.2 Ma, respectively). These ages are similar to those (1815 to 2120 Ma) from granitic gneiss which is widely distributed in the Lesser Himalaya (LHM). The ages of inherited zircons (>2493.9±7.0 Ma, 2095.8± 8.8 Ma, 1874±29 Ma) exhibit the possible presence of several thermal events in Paleoproterozoic. All of the ages suggest the same India basement beneath the different units in Himalaya area, and do not support the idea that the HHM and NHM are accretionary terranes in Pan-Africa orogenic event. The fact that the basement in HHM is as old as or even younger than LHM is inconsistent with the presently prevalent orogenic models such as either extrusion of low-viscosity mid-crust or orogenic channel. | LIAO QunAn LI DeWei LU Lian YUAN YieMing CHU LingLin | 2008 | Science China Earth Sciences2008，51，2： | 5 |
| 2 | Effect of Huanglian Jiedu Decoction on the Behavior of Zebrafish with Alzheimer's Disease显示文摘[Objectives]To study the effect of Huanglian Jiedu Decoction on the behavior of zebrafish with Alzheimer's disease caused by AlCl 3.[Methods]Each portion of Huanglian Jiedu Decoction was prepared according to the proportion of Coptis chinensis∶Phellodendron chinense Rupr.∶Scutellaria baicalensis Georgi∶Gardenia jasminoides Ellis=63 g∶42 g∶42 g∶63 g.After that,each portion of Huanglian Jiedu Decoction was soaked in 6.3 L water for 30 min and boiled twice at 100℃.The extracts were combined twice and filtered,then concentrated to 308 g/L and put into refrigerator for later use.Before training,zebrafishes were put into T-maze to adapt for 2 d,and then behavioral training was carried out for 7 d.After video recording,the behavior of zebrafish was analyzed by Smart 3.0,and qualified zebrafishes were selected for follow-up experiments.Then 60 successfully trained zebrafishes were randomly divided into control group,model group,positive group,low-dose group,medium-dose group and high-dose group of Huanglian Jiedu Decoction.Except for the control group,all the other groups were exposed to 100μg/L AlCl 3 for 7 d.After that,video was recorded,and behavioral analysis was carried out with behavioral record and analysis software Smart 3.0.And then the zebrafishes in the other four groups except the model group were treated with Huperzine A(4μg/L)and Huanglian Jiedu Decoction(154,308,616 mg/L)for 6 d,respectively.After that,it was recorded and the behavior of each group was analyzed.[Results]There was a significant difference in the time spent in the left area and the percentage of time in the left area between the control group and the model group(P<0.001).The time spent in the left area and the percentage of time in the left area in the model group and positive group,low,medium and high dose groups of Huanglian Jiedu Decoction decreased significantly(P<0.05,P<0.01,P<0.001).The swimming distance in the left area and the percentage of swimming distance in the left area in the model group were significantly higher than those in the control group(P<0.001).There was a significant difference in swimming distance between model group and positive group,low,medium and high dose groups of Huanglian Jiedu Decoction(P<0.01,P<0.001).In the percentage of swimming distance in the left area,there was a significant difference between the model group and the low and high dose groups of Huanglian Jiedu Decoction(P<0.01,P<0.001).[Conclusions]Huanglian Jiedu Decoction can improve the behavior of zebrafish with Alzheimer's disease. | Yao HUANG Kaifei LIU Xiaolong CHEN Xuehong HUANG Dianfeng HUANG Ye CHU Jun LU Linglin CHEN Yingyuan QIN Yifei CHEN | 2023 | Medicinal Plant2023，14，1： | 0 |
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