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| 1 | Endoscopic extraction of large common bile duct stones:A review article显示文摘Since therapeutic endoscopic retrograde cholangiopancreatography replaced surgery as the first approach in cases of choledocolithiasis,a plethora of endoscopic techniques and devices appeared in order to facilitate rapid,safe and effective bile duct stones extraction.Nowadays,endoscopic sphincterotomy combined with balloon catheters and/or baskets is the routine endoscopic technique for stone extraction in the great majority of patients.Large common bile duct stones are treated conventionally with mechanical lithotripsy,while the most serious complication of the procedure is 'basket and stone impaction' that is predominately resolved surgically.In cases of difficult,impacted,multiple or intrahepatic stones,more sophisticated procedures have been used.Electrohydraulic lithotripsy and laser lithotripsy are performed using conventional mother-baby scope systems,ultra-thin cholangio-scopes,thin endoscopes and ultimately using the novel single use,single operator SpyGlass Direct Visualization System,in order to deliver intracorporeal shock wave energy to fragment the targeted stone,with very good outcomes.Recently,large balloon dilation after endoscopic sphincterotomy confirmed its effectiveness in the extraction of large stones in a plethora of trials.When compared with mechanical lithotripsy or with balloon dilation alone,it proved to be superior.Moreover,dilation is an ideal alternative in cases of altered anatomy where access to the papilla is problematic.Endoscopic sphincterotomy followed by large balloon dilation represents the onset of a new era in large bile duct stone extraction and the management of 'impaction' because it seems that is an effective,inexpensive,less traumatic,safe and easy method that does not require sophisticated apparatus and can be performed widely by skillful endoscopists.When complete extraction of large stones is unsuccessful,the drainage of the common bile duct is mandatory either for bridging to the final therapy or as a curative therapy for very elderly patients with short life expectancy.Placing of more than one plastic endoprostheses is better while the administration of Ursodiol is ineffective.The great majority of patients with large stones can be treated endoscopically.In cases of unsuccessful stone extraction using balloons,baskets,mechanical lithotripsy,electrohydraulic or laser lithotripsy and large balloon dilation,the patient should be referred for extracorporeal shock wave lithotripsy or a percutaneous approach and finally surgery. | Gerasimos Stefanidis Christos Christodoulou Spilios Manolakopoulos Ram Chuttani | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 23 |
| 2 | Pseudopolyps in inflammatory bowel diseases: Have we learned enough?显示文摘Pseudopolyps are a well described entity in the literature and even though the exact pathogenesis of their formation is not completely understood, they are considered non-neoplastic lesions originating from the mucosa after repeated periods of inflammation and ulceration associated with excessive healing processes. Their occurrence is less common in Crohn's disease than in ulcerative colitis, and their overall prevalence ranges from 4% to 74%; moreover, they are found more often in colon but have been detected in other parts of the gastrointestinal tract as well. When their size exceeds the arbitrary point of 1.5 cm, they are classified as giant pseudopolyps. Clinical evaluation should differentiate the pseudopolyps from other polypoid lesions, such as the dysplasiaassociated mass or lesion, but this situation represents an ongoing clinical challenge. Pseudopolyps can provoke complications such as bleeding or obstruction, and their management includes medical therapy, endoscopy and surgery; however, no consensus exists about the optimal treatment approach. Patients with pseudopolyps are considered at intermediate risk for colorectal cancer and regular endoscopic monitoring is recommended. Through a review of the literature, we provide here a proposed classification of the characteristics of pseudopolyps. | Dimitrios S Politis Konstantinos H Katsanos Epameinondas V Tsianos Dimitrios K Christodoulou | 2017 | World Journal of Gastroenterology2017，23，9： | 8 |
| 3 | Small bowel parasitosis as cause of obscure gastrointestinal bleeding diagnosed by capsule endoscopy显示文摘Hookworm infection is a relatively common cause of anemia in endemic areas.However,it is rarely encountered in Europe.In this report we describe the case of a 24-year old patient originating from an endemic area who was admitted due to severe anemia,with an Hct of 15.6%and eosinophilia(Eosinophils:22.4%).While both esophagogastroduodenoscopy and colonoscopy were non-diagnostic,capsule endoscopy revealed a large number of hookworms infesting his small bowel and withdrawing blood.The patient was successfully treated with Albendazole.Capsule endoscopy was proven an important tool in diagnosing intestinal parasitosis. | Dimitrios K Christodoulou Dimitrios E Sigounas Konstantinos H Katsanos Georgios Dimos Epameinondas VTsianos | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 7 |
| 4 | Lipidomics in non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD),the most common chronic liver disorder in Western countries,comprises steatosis to nonalcoholic steatohepatitis(NASH),with the latter having the potential to progress to cirrhosis.The transition from isolated steatosis to NASH is still poorly understood,but lipidomics approach revealed that the hepatic lipidome is extensively altered in the setting of steatosis and steatohepatitis and these alterations correlate with disease progression.Recent data suggest that both quantity and quality of the accumulated lipids are involved in pathogenesis of NAFLD.Changes in glycerophospholipid,sphingolipid,and fatty acid composition have been described in both liver biopsies and plasma of patients with NAFLD,implicating that specific lipid species are involved in oxidative stress,inflammation,and cell death.In this article,we summarize the findings of main human lipidomics studies in NAFLD and delineate the currently available information on the pathogenetic role of each lipid class in lipotoxicity and disease progression. | Sofia Kartsoli Christina E Kostara Vasilis Tsimihodimos Eleni T Bairaktari Dimitrios K Christodoulou | 2020 | World Journal of Hepatology2020，12，8： | 5 |
| 5 | Role of wireless capsule endoscopy in the follow-up of inflammatory bowel disease显示文摘The introduction of wireless capsule endoscopy in 2000 has revolutionized our ability to visualize parts of the small bowel mucosa classically unreached by the conventional endoscope, and since the recent introduction of colon capsule endoscopy, a promising alternative method has been available for the evaluation of large bowel mucosa. The advantages of wireless capsule endoscopy include its non-invasive character and its ability to visualize proximal and distal parts of the intestine, while important disadvantages include the procedure's inability of tissue sampling and significant incompletion rate. Its greatest limitation is the prohibited use in cases of known or suspected stenosis of the intestinal lumen due to high risk of retention. Wireless capsule endoscopy plays an important role in the early recognition of recurrence, on Crohn's disease patients who have undergone ileocolonic resection for the treatment of Crohn's disease complications, and in patients' management and therapeutic strategy planning, before obvious clinical and laboratory relapse. Although capsule endoscopy cannot replace traditional endoscopy, it offers valuable information on the evaluation of intestinal disease and has a significant impact on disease reclassification of patients with a previous diagnosis of ulcerative colitis or inflammatory bowel disease unclassified/indeterminate colitis. Moreover, it may serve as an effective alternative where colonoscopy is contraindicated and in cases with incomplete colonoscopy studies. The use of patency capsule maximizes safety and is advocated in cases of suspected small or large bowel stenosis. | Ioannis V Mitselos Dimitrios K Christodoulou Konstantinos H Katsanos Epameinondas V Tsianos | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 4 |
| 6 | Use of demineralized bone matrix in spinal fusion显示文摘Spinal fusion remains the gold-standard treatment for several pathological spine conditions. Although, autologous Iliac Crest Bone Grafting is considered the goldstandard graft choice to promote spinal fusion; however, it is associated with significant donor site morbidity and a limited graft quantity. Therefore, several bone graft alternatives have been developed, to augment arthrodesis. The purpose of this review is to present the results of clinical studies concerning the use of demineralized bone matrix(DBM), alone or as a composite graft, in the spinal fusion. A critical review of the English-language literature was conducted on Pubmed, using key word 'demineralized bone matrix', 'DBM', 'spinal fusion', and 'scoliosis'. Results had been restricted to clinical studies. The majority of clinical trials demonstrate satisfactory fusion rates when DBM is employed as a graft extender or a graft enhancer.Limited number of prospective randomized controlled trials(4 studies), have been performed comparing DBM to autologous iliac crest bone graft in spine fusion. The majority of the clinical trials demonstrate comparable efficacy of DBM when it used as a graft extender in combination with autograft, but there is no clinical evidence to support its use as a standalone graft material. Additionally, high level of evidence studies are required, in order to optimize and clarify the indications of its use and the appropriate patient population that will benefit from DBM in spine arthrodesis. | Konstantinos Tilkeridis Panagiotis Touzopoulos Athanasios Ververidis Sotirios Christodoulou Konstantinos Kazakos Georgios I Drosos | 2014 | World Journal of Orthopedics2014，5，1： | 4 |
| 7 | Study of the Electric Filed Around a Metal Oxide Surge Arrester: Measurement and Simulation显示文摘The study of the electric field around a surge arrester is useful for design procedures and diagnostic tests. The current work com- putes the electric field around a medium voltage gapless surge arrester using 2D and 3D representation of the arrester. The 2D simulation design, which is described in IEC 60099-4 Standard, cannot include the non symmetrical parts of the arrester geometry and the test arrange- ment. 3D simulation procedures have the advantage that takes into account these asymmetries, giving more accurate results for each measurement position. In order to confirm the suitability of the created models, the simulation results of the electric field, using the 2D and 3D edition of PC Opera, are compared with recorded measurements, which are obtained in laboratory using appropriate calibrated field meters. | Christodoulou C A Spanias C A Kontargyri V T Gonos I F Stathopulos I A | 2013 | 高电压技术2013，39，8： | 4 |
| 8 | Metastatic melanoma of the gallbladder: An unusual clinical presentation of acute cholecystitis显示文摘Metastatic disease from cutaneous melanoma can af-fect all organs of the body, and varies in its biological behavior and clinical presentation. We present the case of a 58-year-old man who arrived at our clinic with acute abdominal pain, which, after investigation, was diagnosed as acute cholecystitis. The patient under-went laparotomy and cholecystectomy. Two years ago, he underwent surgical removal of a primary cutaneous melanoma on his right upper back. Pathological exami-nation revealed the presence of malignant melanoma with a metastatic lesion of the gallbladder. | Spiridon Vernadakis Georgios Rallis Nikolaos Danias Costas Serafi midis Evangelos Christodoulou Michail Troullinakis Nikolaos Legakis Georgios Peros | 2009 | World Journal of Gastroenterology2009，15，27： | 3 |
| 9 | Acute ulcerative jejunal diverticulitis:Case report of an uncommon entity显示文摘Jejunal diverticulosis is a rare entity with variable clinical and anatomical presentations.Its reported incidence varies from 0.05% to 6%.Although there is no consensus on the management of asymptomatic jejunal diverticular disease,some complications are potentially life threatening and require early surgical treatment.We report a case of an 88-year-old man investigated for acute abdominal pain with a high biological inflammatory syndrome.Inflammation of multiple giant jejunal diverticulum was discovered at abdominal computed tomography (CT).As a result of the clinical and biological signs of early peritonitis,an emergency surgical exploration was performed.The first jejunal loop showed clear signs of jejunal diverticulitis.Primary segmental jejunum resection with end-to-end anastomosis was performed.Histopathology report confirmed an ulcerative jejunal diverticulitis with imminent perforation and acute local peritonitis.The patient made an excellent rapid postoperative recovery.Jejunal diverticulum is rare but may cause serious complications.It should be considered a possible etiology of acute abdomen,especially in elderly patients with unusual symptomatology.Abdominal CT is the diagnostic tool of choice.The best treatment is emergency surgical management. | Wojciech Staszewicz Michel Christodoulou Stefania Proietti Nicolas Demartines | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 10 | Role of endoscopic retrograde cholangiopancreatography in pancreatic diseases显示文摘Over the last 15 years,endoscopic retrograde cholangiopancreatography (ERCP) has evolved from a diagnostic tool to one that is primarily used to provide therapy. This development occurred f irst for biliary disorders and subsequently to a lesser extent for pancreatic diseases. Computed tomography, magnetic resonance imaging,magnetic resonance cholangiopancreatography and endoscopic ultrasonography suggest a diagnosis in the majority of patients with pancreatic diseases today and can help physicians and patients avoid unnecessary ERCP. However, a selected number of patients with pancreatic diseases may benef it from pancreatic endotherapy and avoid complex surgery and chronic use of medications. Pancreatic sphincterotomy, pancreatic stenting and pancreatic cyst drainage are some of the most effective and challenging endoscopic pancreatic interventions and should be performed with caution by expert therapeutic endoscopists.There has been a paucity of randomized studies investigating endoscopic techniques in comparison with surgery and medical therapy for the treatment of most benign and malignant pancreatic disorders due to the limited number of patients and the expertise required to attempt these procedures. | Dimitrios K Christodoulou Epameinondas V Tsianos | 2010 | World Journal of Gastroenterology2010，16，38： | 3 |
| 11 | Prognostic significance of proliferating cell nuclear antigen expression in glioma显示文摘 | Korkolopoulou P Christodoulou P Lekka-Katsouli I | 1994 | Histopathol1994，25，： | 2 |
| 12 | Gastrointestinal bleeding and obstructive jaundice: Think of hepatic artery aneurysm显示文摘Hemobilia is an uncommon and potential life-threatening condition mainly due to hepato-biliary tree traumatic or iatrogenic injuries.Spontaneously ruptured aneurysm of the hepatic artery is seldom described.We report the case of an 89-year-old woman presenting with abdominal pain,jaundice and gastrointestinal bleeding,whose ultrasound and computed tomography revealed a non-traumatic,spontaneous aneurysm of the right hepatic artery.The oeso-gastro-duodenoscopy and colonoscopy did not reveal any bleeding at the ampulla of Vater,nor anywhere else.Selective angiography confirmed the diagnosis of hepatic artery aneurysm and revealed a full hepatic artery originating from the superior mesenteric artery.The patient was successfully treated by selective embolization of microcoils.We discuss the etiologies of hemobilia and its treatment with selective embolization,which remains favored over surgical treatment.Although aneurysm of the hepatic artery is rare,especially without trauma,a high index of suspicion is needed in order to ensure appropriate treatment. | Fabrice Vultaggio Pierre-Henri Morère Christophe Constantin Michel Christodoulou Didier Roulin | 2016 | World Journal of Gastrointestinal Surgery2016，8，6： | 2 |
| 13 | Association of Helicobacter pylori infection with cardiovascular disease—Is it just a myth?显示文摘 | Dimitrios K. Christodoulou Haralampos J. Milionis Panagiota Pappa Konstantinos H. Katsanos Dimitrios Sigounas Matilda Florentin Moses Elisaf Epameinondas V. Tsianos | 2010 | European Journal of Internal Medicine2010，，2： | 2 |
| 14 | Diagnosis and endoscopic treatment of esophago-bronchial fistula due to gastric heterotopy显示文摘Heterotopic gastric mucosa patches are congenital gastrointestinal abnormalities and have been reported to occur anywhere along the gastrointestinal tract from mouth to anus.Complications of heterotopic gastric mucosa include dysphagia,upper gastrointestinal bleeding,upper esophageal ring stricture,adenocarcinoma and fistula formation.In this case report we describe the diagnosis and treatment of the first case of esophago-bronchial fistula due to heterotopic gastric mucosa in mid esophagus.A 40-year old former professional soccer player was referred to our department for treatment of an esophago-bronchial fistula.Microscopic examination of the biopsies taken from the esophageal fistula revealed the presence of gastric heterotopic mucosa.We decided to do a non-surgical therapeutic endoscopic procedure.A sclerotherapy catheter was inserted through which 1 mL of ready to use synthetic surgical glue was applied in the fistula and it closed the fistula opening with excellent results. | Konstantinos H Katsanos Dimitrios K Christodoulou Sevasti Kamina Kosmidou Maria Evangelia Lambri Stavroula Theodorou Konstantinos Tsampoulas Mitsi Vasiliki Epameinondas V Tsianos | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，4： | 2 |
| 15 | New trends in fixation of proximal humeral fractures: A review显示文摘 | Dimitrios Karataglis Stavros I. Stavridis George Petsatodis Pericles Papadopoulos Anastasios Christodoulou | 2010 | Injury2010，，4： | 2 |
| 16 | Hydrogen embrittlement and trapping in Al-6%Zn-3%Mg 显示文摘 | Christodoulou L Flower H M | 1980 | Acta Metall1980，28，2： | 2 |
| 17 | A step towards designing Fe-Cr-B-C cast alloys显示文摘 | Calos N | 2001 | Materials Science and Engineering2001，301，1： | 1 |
| 18 | The appearance of kissing contusion in the acutely injured knee in the athletes显示文摘 | Terzidis IP Christodoulou AG Ploumis AL | 2004 | Br J Sports Med2004，38，5： | 1 |
| 19 | Chained aggregation of singular system显示文摘 | Christodoulou M A Mertzios B G | 1989 | IEEE Trans on Automatic and Control1989，34，9： | 1 |
| 20 | Internal fixation of scaphoid non-union:a comparative study of three methods显示文摘 | Kitsis CK Chamberlain ST | 2001 | Injury2001，32，8： | 1 |
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