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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?显示文摘Virus infections have been implicated in both initiation of and protection from autoimmune diseases,such as type 1 diabetes(T1D).In this review we intend to reflect on recent evidence how viruses might on the one hand be involved in the pathogenesis of T1D and on the other hand induce a state of protection from autoimmune-mediated damage.It is important to acknowledge that human individuals encounter more than just one virus infection in their lifetime.Therefore,it is important to integrate more than just one possible environmental triggering factor for autoimmune diseases to occur. | Urs Christen Matthias G von Herrath | 2011 | Cellular & Molecular Immunology2011，8，3： | 4 |
| 3 | Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli显示文摘 | Kristin V. T. Engebretsen Ida G. Lunde Mari E. Strand Anne Waehre Ivar Sjaastad Henriette S. Marstein Biljana Skrbic Christen P. Dahl Erik T. Askevold Geir Christensen Johannes L. Bj?rnstad Theis T?nnessen | 2013 | FEBS J2013，，10： | 2 |
| 4 | Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C显示文摘 | Christine Bernsmeier Francois H.T. Duong Verena Christen Paolo Pugnale Francesco Negro Luigi Terracciano Markus H. Heim | 2008 | Journal of Hepatology2008，，3： | 2 |
| 5 | Job Satis faction,Job Performance,and Effort:A Reexamination Using Agency Theory显示文摘 | Markus Christen Ganeshlyer David Soberman | 2006 | Journal of Marketing2006，70，1： | 1 |
| 6 | ChitoEDTA eomugate: a novel polymer for topical 显示文摘 | VALENTA C CHRISTEN H SEHNURCH A B | 1998 | Pharm Pharmacol1998，50，5： | 1 |
| 7 | A review of the fate of potassium in the soil-plant system after land application of wastewaters显示文摘 | Arienzo M Christen E W Quayle W | 2009 | Journal of Hazardous Materials2009，164，： | 1 |
| 8 | Aminotransferases:demonstration of homology and division into evolutionary subgroups显示文摘 | Hale T I and Christen P | 1993 | Eur J Biochem1993，214，： | 1 |
| 9 | Quantification and control of the sulfur c(2 × 2) superstructure on {100} (100) Ni for optimization of YSZ, CeO2 and SrTiO3 seed layer texture显示文摘 | Cantoni C Christen D K Heatherly L | 2002 | Journal of Materials Research2002，17，10： | 1 |
| 10 | Hostile media perceptions: Partisan assessments of press and public during the 1997 UPS strike 显示文摘 | Christen C T Karmaovakun P Gunther A C | 2002 | Political Com- munication2002，19，4： | 1 |
| 11 | Phase I/ pharmacokinetic study of high-dose progesterone and doxorubicin显示文摘 | Christen RD McClay EF Plaxe SC | 1993 | J Clin Oncol1993，11，： | 1 |
| 12 | Prodromal unstable angina in acute myocardial infarction:prognostic value of short-and long-term outcome and predictor of infarct size显示文摘 | Bahr RD leino EV Christen son RH | 2000 | Am Heart J2000，140，： | 1 |
| 13 | VHDL-AMS-A hardware description language for analog and mixed-signal applications 显示文摘 | Christen E Bakalar K | 1999 | IEEE Transactions on Circuits and Systems-Ⅱ: Analog and Digital Signal Processing1999，46，10： | 1 |
| 14 | A randomized trial of lowdose,topical mitomycin-C in the treatment of servere vernal keratoconjunctivitis 显示文摘 | Akpek EK Hasiripi H Christen WG | 2000 | Ophthalmology2000，107，2： | 1 |
| 15 | Current status of platinum-based anti- tumor Drugs显示文摘 | Erndest W Christen MG | 1999 | Chem Rev1999，99，： | 1 |
| 16 | Numerical investigation of the influence of rock shape on rockfall trajectory显示文摘 | Glover J Schweizer A Christen M Gerber W Leine R Bartelt P | 2012 | Geophysical Research Abstracts2012，14，11： | 1 |
| 17 | Hemodynamic effects of intermittent pneumatic compression of the lower limbs during laparo- scopic cholecystectomy 显示文摘 | Christen Y Reymond MA Vogel J J | 1995 | Am J Surg1995，170，： | 1 |
| 18 | Energy and radiation balance of a central European city 显示文摘 | Christen A Vogt R | 2004 | International Journal of Cli- matology2004，24，11： | 1 |
| 19 | Effect of sulfur surface structure on nucleation of oxide seed layers on textured metals for coated conductor applications 显示文摘 | Cantoni C Christen D K Goyal A | 2002 | Materials Research Society2002，689，： | 1 |
| 20 | Gamma-tocopherol traps mutagenic electrophiles such as NOx and complements alpha-tocopherol: physiological implications显示文摘 | Christen S Woodall AA Shigenaga MK | 1997 | Proc Natl Acad Sci USA1997，94，7： | 1 |
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