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| 1 | ALK易位性甲状腺乳头状癌的临床病理分析显示文摘目前,有报道指出甲状腺乳头状癌( PTC)中存在致病基因ALK的易位。作者在免疫组化的基础上,对免疫组化阳性病例通过荧光原位杂交( FISH)进一步识别ALK重排型PTC。本文对259例侵袭性较强的甲状腺癌进行免疫组化和FISH分析,8例免疫组化阳性的病例中,通过FISH证实有6例存在ALK易位,特异性为75%;其余251例免疫组化阴性的病例, FISH检查同样阴性,敏感性为100%。在498例未经筛选过的PTCs中,11例(2.2%)发现ALK易位,23例弥漫性硬化型PTCs中3例(13%)发现ALK易位;36例伴远处转移的PTCs、28例差分化癌(岛状癌)、20例间变性癌中未发现ALK易位;14例ALK易位的患者全部为女性( P=0.0425),且发生在较年轻的患者(平均年龄38岁,而所有患者的平均48岁,P=0.0289)。 ALK易位出现在所有肿瘤细胞的早期克隆性事件中,与 BRAFV600E 突变相互排斥。 ALK易位与侵袭性的临床病理特征无关(包括瘤体大小、分期、转移、血管侵犯、腺外播散、复发的风险及放射性碘抵抗性)。作者通过免疫组化和FISH发现2.2%的PTCs中存在ALK的易位,ALK易位在年轻女性和弥漫硬化型PTC患者中更加常见,但并不意味着侵袭性的临床过程。 | Chou A Fraser S Toon C W 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015，31，5： | 11 |
| 2 | Novel DNA vaccine based on hepatitis B virus core gene induces specific immune responses in Balb/c mice显示文摘AIM: To investigate the immunogenicity of a novel DNA vaccine,pSW3891/HBc, based on HBV core gene in Balb/c mice.METHODS: A novel DNA vaccine, pSW3891/HBc, encoding HBV core gene was constructed using a vector plasmid pSW3891. Balb/c mice were immunized with either pSW3891/HBc or empty vector DNA via gene gun. IgG anti-HBc responses in mouse sera were demonstrated by ELISA. Specific cytotoxicity of cytotoxic T lymphocytes (CTLs) of mice was quantitatively measured by lactate dehydrogenase release assay.RESULTS: HBcAg was expressed effectively in 293T cell line transiently transfected with pSW3891/HBc. Strong IgG anti-HBc responses were elicited in mice immunized with pSW3891/HBc. The end-point titers of anti-HBc reached the highest 1:97 200, 4 wk after the third immunization. The specific CTL killing with the highest specific lysis reached 73.25% at effector:target ratio of 20:1 in mice that received pSW3891/HBc DNA vaccine.CONCLUSION: pSW3891/HBc vaccination elicits specific anti-HBc response and induces HBc-specific CTL response in immunized Balb/c mice. | Yi-Ping Xing Zu-Hu Huang Shi-Xia Wang Jie Cai Jun Li Te-Hui W Chou Shan Lu | 2005 | World Journal of Gastroenterology2005，11，29： | 7 |
| 3 | Fiber inclination model of three dimensional textile structural composites 显示文摘 | Yang J M Chou T W | 1986 | Journal of Composites Material1986，20，5： | 3 |
| 4 | β-Rhizobia from Mimosa pigra, a newly discovered invasive plant in Taiwan 显示文摘 | CHEN W M JAMES E K CHOU J H | 2005 | New Phytologist2005，168，3： | 1 |
| 5 | Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice显示文摘 | Chou M W Yan J Nichols J | 2003 | Cancer Lett2003，193，： | 1 |
| 6 | 显示文摘 | Chou Y S Stevenson J W Gow R N | 2007 | Journal of Power Sources2007，168，： | 1 |
| 7 | Shooting and bouncing rays: calculating the RCS of an arbitrarily shaped cavity 显示文摘 | Ling H Chou Pt C Lee S W | 1989 | IEEE Transactions on Antennas and Propagation1989，37，2： | 1 |
| 8 | Mechanical prope- rties of TiN thin film coatings on 304 stainless steel substrates显示文摘 | CHOU W J YU G P HUANG J H | 2002 | Serface and Coatings Technology2002，，149： | 1 |
| 9 | Isolation and characterization of 23 polymorphic microsatellite markers for diversity and stock analysis in tiger shrimp (Penaeus monodon) 显示文摘 | Yu W P Chou H H You E M | 2004 | Mol Eco Notes2004，4，： | 1 |
| 10 | Eu Substitution and Particle Size Control of Y2O2S for the Excitation by UV Light Emitting Diodes显示文摘 | Chou T W Mylswamy S Liu R S | 2005 | Solid State Communications2005，136，： | 1 |
| 11 | Surface heat budgets and sea surface temperature in the Pacific warm pool during TOGA COARE 显示文摘 | Chou S H Zhao W Chou M D | 2000 | J Climate2000，13，3： | 1 |
| 12 | Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia显示文摘 | Hou H A Chou W C Lin L I | 2008 | Leuk Res2008，32，6： | 1 |
| 13 | The performance of lightness difference formula 显示文摘 | CHOU W LIN H LUO M R | 2001 | Coloration Technology2001，，11： | 1 |
| 14 | Anti-fungal activity of crude extracts and essential oil of Moringa oleifera Lam显示文摘 | Chuag P H Lee C W Chou J Y | 2007 | Bioresource Technology2007，98，1： | 1 |
| 15 | A comparative study of damage sensing in fiber composites using uniformly and non-uni- forrnly dispersed carbon nanotubes 显示文摘 | Gao L Chou T W Thostenson E T | 2010 | Carbon2010，48，13： | 1 |
| 16 | Effect of Tai Chi on depressive symptoms amongst Chinese older patients with depressive disorders:a randomized clinical trial显示文摘 | CHOU K L LEE P W YU E | 2004 | Int J Geriatr Psych2004，19，11： | 1 |
| 17 | Microwave processing:fundamentals and applications显示文摘 | Thostenson E T Chou T W | | 0，，： | 1 |
| 18 | Compaction of woven-fabric preforms in liquid composite molding processes: Single-layer deformation 显示文摘 | Chen B Chou T W | 1999 | Composites Science and Technology1999，59，10： | 1 |
| 19 | Environmental influence on coastal phytoplankton and zooplankton diversity:A multivariate statistical model analysis显示文摘 | Chou W R Fang L S Wang W H | 2012 | Environmental Monitoring and Assessment2012，184，9： | 1 |
| 20 | Development of micro power generator--a review显示文摘 | Chou S K Yang W M Chua K J | 2011 | Applied Energy2011，88，1： | 1 |
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