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| 1 | 蒿甲醚对感染小鼠体内埃及血吸虫皮层的损害(英文)显示文摘目的评价蒿甲醚对小鼠体内埃及血吸虫皮层的损害作用。方法8只小鼠于感染埃及血吸虫尾蚴后81d,用单剂蒿甲醚400mg/kg口服治疗。治疗后1、3、7和14d各剖杀2只小鼠,用灌注法收集血吸虫,并按常规方法固定和处置虫体,作扫描电镜观察。从另2只未作治疗的感染小鼠取虫作对照。结果用蒿甲醚治疗后24h,雄虫的皮层结节肿大、破溃或从皮层上剥落;在雄虫和雌虫的体表可查见有局灶性或广泛的皮层肿胀、融合、空泡变化、糜烂和剥落,以及感觉结构的破坏。治疗后3d,雌、雄虫的皮层损害加重,最严重的损害为口吸盘肿胀和破溃,并查见皮层褶嵴有广泛和严重的肿胀、糜烂和剥落,以及雌虫盘状感觉结构的破坏。治疗后7至14d,有些虫仍示有中或重度皮层损害,而有些仍存活的虫则示其大部分皮层已有明显恢复。结论蒿甲醚对埃及血吸虫的皮层具有广泛和严重的损害作用。 | 肖树华 Marcel TANNER 沈炳贵 Jürg UTZINGER Jacques CHOLLET | 2006 | 中国寄生虫学与寄生虫病杂志2006，24，6： | 6 |
| 2 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 3 | Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway显示文摘Sclareol,an antifungal specialized metabolite produced by clary sage,Salvia sclarea,is the starting plant natural molecule used for the hemisynthesis of the perfume ingredient ambroxide.Sclareol is mainly produced in clary sage flower calyces;however,the cellular localization of the sclareol biosynthesis remains unknown.To elucidate the site of sclareol biosynthesis,we analyzed its spatial distribution in the clary sage calyx epidermis using laser desorption/ionization mass spectrometry imaging(LDI–FTICR-MSI)and investigated the expression profile of sclareol biosynthesis genes in isolated glandular trichomes(GTs).We showed that sclareol specifically accumulates in GTs’gland cells in which sclareol biosynthesis genes are strongly expressed.We next isolated a glabrous beardless mutant and demonstrate that more than 90%of the sclareol is produced by the large capitate GTs.Feeding experiments,using 1-13 C-glucose,and specific enzyme inhibitors further revealed that the methylerythritol-phosphate(MEP)biosynthetic pathway is the main source of isopentenyl diphosphate(IPP)precursor used for the biosynthesis of sclareol.Our findings demonstrate that sclareol is an MEP-derived diterpene produced by large capitate GTs in clary sage emphasing the role of GTs as biofactories dedicated to the production of specialized metabolites. | Camille Chalvin Stephanie Drevensek Françoise Gilard Caroline Mauve Christel Chollet Halima Morin Edith Nicol Eva Heripre Lucie Kriegshauser Bertrand Gakiere Michel Dron Abdelhafid Bendahmane Adnane Boualem | 2021 | Horticulture Research2021，8，1： | 2 |
| 4 | Endothelin-1 is a growth factor for corneal endothelium显示文摘 | Chollet S Malecaze F Gouzi L | 1993 | Exp Eye Res1993，57，： | 2 |
| 5 | The effect of combined self- and expert-modelling on the performance of the double leg circle on the pommel horse显示文摘 | L. Baudry D. Leroy D. Chollet | 2006 | Journal of Sports Sciences2006，，10： | 2 |
| 6 | 蒿甲醚对曼氏血吸虫的作用 :剂量与效应的关系和虫的形态学和组织病理学的变化(英文)显示文摘目的 应用感染曼氏血吸虫 (利比里亚株 )的小鼠观察蒿甲醚单剂量与效应的关系 ,虫体肝移及蒿甲醚所引起的虫的形态学和组织病理学变化。 方法 感染 2 1d童虫的小鼠一次口服蒿甲醚 12 .5mg/kg至 60 0mg/kg不同剂量 ,治后 2 8d剖检观察各组虫数。感染 46d或 70d成虫的小鼠一次口服蒿甲醚 40 0mg/kg后 8~ 14d ,观察虫体肝移及其形态和组织病理学变化。 结果 蒿甲醚对 2 1d童虫的最低有效剂量为 2 0 0mg/kg ,减虫率为 81%。用蒿甲醚治疗后 8h成虫开始肝移 ,3~ 7d全部肝移 ,14d有 3 1%的虫返回肠系膜静脉。成虫虫体萎缩 ,咽部扩大 ,肠管膨胀及其色素减少。雌虫局部体表受损 ,白细胞附着 ,卵巢及卵黄腺变性退化 ,以及雄虫睾丸萎缩等。在肝内的虫体被嗜酸粒细胞为主的炎细胞包围和浸润。 结论 蒿甲醚对小鼠曼氏血吸虫 2 1d童虫的最低有效剂量为 2 0 0mg/kg ,可引起曼氏血吸虫成虫萎缩、退化或死亡。在肝内受损的虫体主要是被嗜酸粒细胞包围和侵袭所致。 | 肖树华 郭俭 Jacques Chollet 吴嘉彤 Marcel Tanner Jurg Utzinger | 2004 | 中国寄生虫学与寄生虫病杂志2004，22，3： | 2 |
| 7 | Functional reorganization of the brain in recovery from striatocapsular infarction in man 显示文摘 | Weiller C Chollet F Friston K | 1992 | Ann Neurol1992，31，： | 2 |
| 8 | Prognostic significance of a compiete pathological response after indunction chemotherapy in operable breast cancer显示文摘 | Chollet P Amat S Cure H | 2002 | Br J Cancer2002，86，7： | 1 |
| 9 | Matrix metalloproteinase-2 ( MMP-2 ) regulatesastrocyte motility in connection with the actincytoskeleton and integrins 显示文摘 | OGIERC BERNARD A CHOLLET A M | 2006 | Glia2006，54，4： | 1 |
| 10 | Spire and dispiro-1,2,4-trioxolanes as antimalarial peroxides:charting a workable structure-activity relationship using simple prototypes显示文摘 | Dong Y Chollet J Matile H | 2005 | J Med Chem2005，48，15： | 1 |
| 11 | Immunocytochemical characterization of pulmonary histiocytosis X cells in lung biopsies显示文摘 | Soler P Chollet S Jacque C | 1985 | Am J Pathol1985，118，3： | 1 |
| 12 | Phase Ⅱ study of OSI-211 (liposomal lurtotecan) in patients with metastatic or loco-regional recurrent squamous cell carcinoma of the head and neck显示文摘 | Duffaud F Borner M Chollet P | 2004 | Eur J Cancer2004，40，18： | 1 |
| 13 | Induction brazing of diamond with Ni-Cr hardfacing alloy under argon atmosphere显示文摘 | Chattophdhyny A K Chollet L Hintermann H E | 1991 | Surface and Coatings Technology1991，，45： | 1 |
| 14 | Phosphoenolpyruvate earboxylase:a ubiquitous,highly regulated enzyme in plants显示文摘 | Chollet R Vidal J O'Leary M H | 1996 | Ann Rer Plant Physiol Plant Mol Biol1996，47，： | 1 |
| 15 | Hypo-oxygenation in paraquat poisoning: Apropos of 6 cases 显示文摘 | Chollet A Muszynsky J Bismuth C | 1983 | Toxicol Eur Res1983，5，： | 1 |
| 16 | Induction Brazing of Diamond with Ni-Cr Hardfacing Alloy under Argon Atmosphere显示文摘 | Chattopadhyay A K Chollet L Hintermann H E | 1991 | Surface and Coating Technology1991，45，： | 1 |
| 17 | On Performance of brazed bonded mono layer diamond grinding wheel 显示文摘 | Chattopadhyay A K Chollet L Hintermann H E | 1991 | Annals of the CIRP1991，40，1： | 1 |
| 18 | Combined effect of volatile antimicrobial agents on the growth of Penicillium notatum显示文摘 | Tunc S E Chollet P Chalier | | 0，，03： | 1 |
| 19 | In vitro antileishmanial activity of fluoro artemisinin derivatives against Leishmania donovani 显示文摘 | CHOLLET C CROUSSE B BORIES C | 2008 | Biol Med Pharmacother2008，62，7： | 1 |
| 20 | PHOSPHOENOLP- YRUVATE CARBOXYLASE: AUbiquitous, Highly Regulated Enzyme in Plants 显示文摘 | Chollet R Vidal J O'Leary M H | 1996 | Plant Mol Biol1996，47，： | 1 |
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