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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 3 | The quality of reconstructed 3D images in mutidetector-row helical CT: experimental study involving scan parameters显示文摘 | Shin J H Lee H K Choi C G | 2002 | Korean J Radiol2002，3，1： | 2 |
| 4 | Non-Linear Transient Analysis of Rotor-Casing Rub Events显示文摘 | Choy F K Padovan J | 1987 | Journal of Sound and Vibration1987，113，3： | 2 |
| 5 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 6 | Preoperative hyperfractionated radiotherapy with concurrent chemotherapy in resectable esophageal cancer显示文摘 | Kim J H Choi E K Kim S B | 2001 | Int J Radiat Oncol Biol Phys2001，50，1： | 2 |
| 7 | Polymer-polymer miscibility study for plastic gradient index optical fiber 显示文摘 | LEE B CHOI W Y WALKER J K | 2000 | Polym Eng Sci2000，40，9： | 1 |
| 8 | Field experiments on mitigation of harmful algal blooms using a Sophorolipid-Yellow clay mixture and effects on marine plankton 显示文摘 | LEE Y J CHOI J K KIM E K | 2008 | Harmful Algae2008，7，： | 1 |
| 9 | Formation of ultrafine ferrite by strain- induced dynamic transformation in plain low carbon steel 显示文摘 | Choi J K Seo D H Lee J S | 2003 | ISIJ International2003，43，5： | 1 |
| 10 | Study of the enhanced thermal conductivity of Fe nanofluids显示文摘 | Hong T K Yang H S Choi C J | 2005 | Journal of Applied Physics2005，97，6： | 1 |
| 11 | An interactive procedure for multiple attribute group decision-making with incomplete information: Range-based approach显示文摘 | CHOI S H KIM J K | 1999 | Euro J Oper Res1999，118，： | 1 |
| 12 | New Parametric Affine Modeling and Control for Skid-to-Turn Missiles显示文摘 | Choi J Y | 2001 | IEEE Transactions on Control Systems Technology2001，9，2： | 1 |
| 13 | SiC enhanced nucleation of diamond under high presssure and high temperature显示文摘 | CHOI J Y PARK J K EUN K Y | 1996 | Diamond and Related Materials1996，5，： | 1 |
| 14 | Polymerase chain reaction(PCR)for human herpes virus 8 and heteroduplex PCR for clonality assessment in angiolymphoid hyperplasia with eosinophilia and Kimura's disease显示文摘 | Jang K A Ahn S J Choi J H | 2001 | J Cutan Pathol2001，28，： | 1 |
| 15 | Antifungal activity of the methanol extract of Myristica malabarica fruit rinds and the active ingredients malabaricones against phytopathogenic fungi 显示文摘 | Choi H N Choi J G Jang S K | 2008 | Plant Pathol2008，24，3： | 1 |
| 16 | Low pressure sintering of Sialon using different sintering additives 显示文摘 | Jung H J Aim K Y Choi C | 2008 | Journal of the Ceramic Society of Japan2008，116，1： | 1 |
| 17 | Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E cadherin/beta catenin complex 显示文摘 | Choi H N Kim K R Lee J H | 2009 | Oncol Rep2009，21，1： | 1 |
| 18 | Cholangioearcinoma:pictorial essay of CT and cholangiographic findings显示文摘 | Han J K Choi B I Kim A Y | 2002 | Radiographics2002，22，1： | 1 |
| 19 | Underwater autonomous manipulation for intervention missions AUVs 显示文摘 | Marani G Choi S K Yuh J | 2009 | Ocean Engineering2009，36，1： | 1 |
| 20 | Compact ultra - wideband printed antenna with band-rejection characteristic 显示文摘 | Choi W Chung K Jung J | 2005 | Electronic letters2005，41，18： | 1 |
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