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| 1 | 青春期多囊卵巢综合征诊治共识显示文摘对于青春期女性的多囊卵巢综合征(PCOS),目前国内外尚无公认的统一诊断标准,且治疗方案的选择也不尽相同。为使国内各级妇产科医师更好地诊治和管理青春期PCOS患者,更新知识,并与国际接轨,国内该领域的专家在参考国外相关共识及指南后,结合我国的具体情况,编写了'青春期多囊卵巢综合征诊治共识',以改变临床医生对PCOS的传统认识,达到规范诊断和治疗青春期PCOS患者的目的。 | Reproductive Endocrinology Group,Chinese Maternal & Child Health Industry Association,National Association of Health Industry & Enterprise Management | 2016 | 生殖医学杂志2016，25，9： | 62 |
| 2 | 小花棘豆(Oxytropis glabra DC.)内生真菌的培养与鉴定显示文摘小花棘豆(Oxytropis glabra DC.)是内蒙古草原上的重要毒草,实验结合微生物学和分子生物学手段进行了其内生真菌研究。结果表明:体外培养的小花棘豆内生真菌生长缓慢,呈圆形、隆起、边缘整齐、辐射状生长的白色菌落,后菌体分泌黑褐色的色素物质,分生孢子近圆柱形,有粗且比孢子壁厚的暗色横隔膜,隔膜数1-5个。10个菌株的5.8S rDNA/ITS序列与内生真菌Embellisia sp.L12株的序列高度相似。推测该内生真菌属于Embellisia。 | 卢萍 Dennis Child 赵萌莉 Dale R Gardener 吕桂芬 韩国栋 | 2009 | 生态学报2009，29，1： | 29 |
| 3 | 类似卵巢性索肿瘤的子宫肿瘤:一种以复发性NCOA2/3基因融合为特征的独特肿瘤实体显示文摘类似卵巢性索肿瘤的子宫肿瘤(UTROSCT)是一类组织学发生尚不清楚、恶性潜能未定的罕见肿瘤,其形态学类似卵巢性索-间质肿瘤,具有多向分化的免疫表型,分子致病机制尚不清楚. | Dickson B C Childs T J Colgan T J 赵芳(摘译) 魏建国(审校) | 2019 | 临床与实验病理学杂志2019，35，7： | 16 |
| 4 | Feature Extraction of Chinese Materia Medica Fingerprint Based on Star Plot Representation of Multivariate Data显示文摘Objective To study a novel feature extraction method of Chinese materia medica(CMM) fingerprint.Methods On the basis of the radar graphical presentation theory of multivariate,the radar map was used to figure the non-map parameters of the CMM fingerprint,then to extract the map features and to propose the feature fusion.Results Better performance was achieved when using this method to test data.Conclusion This shows that the feature extraction based on radar chart presentation can mine the valuable features that facilitate the identification of Chinese medicine. | CUI Jian-xin1,2,HONG Wen-xue1,ZHOU Rong-juan3,GAO Hai-bo1 1.College of Electrical Engineering,Yanshan University,Qinhuangdao 066004,China 2.Key Laboratory of Measurement Technology and Instrumentation of Hebei Province,Qinhuangdao 066004,China 3.Maternal and Child Health Hospital of Qinhuangdao,Qinhuangdao 066004,China | 2011 | Chinese Herbal Medicines2011，3，2： | 14 |
| 5 | Multiligament knee injuries with associated tibial plateau fractures: A report of two cases显示文摘The management of a combination of fracture and multiligament knee injury(MKI) in traumatic knee injury remains controversial, and there are evolving treatment recommendations. Currently, there are no studies focusing on older adult patients with MKI's in combination with tibia fractures. As a result, there is no well-established treatment algorithm for older adult patients with these complex injuries. We report two cases of MKI's with concomitant fractures in patients fifty years of age or older. Both patients were treated surgically for their associated tibial plateau fractures, but were managed with conservative treatment of the multiligamentous knee injuries. We also provide a review of the literature and guidelines for older adult patients with these types of complex traumatic injuries. Early to mid term acceptable outcomes were achieved for both patients through surgical fixation of the tibial plateau fracture and conservative treatment of the ligament injuries. We propose a comprehensive treatment algorithm for management of these complex injuries. | Vani J Sabesan Paul J Danielsky Abby Childs Tom Valikodath | 2015 | World Journal of Orthopedics2015，6，3： | 14 |
| 6 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 7 | 生物质混燃发电政策研究显示文摘生物质混燃发电技术是一种重要的生物质发电技术,与生物质直燃发电技术相比,有着投资少、建设周期短、对原料价格控制能力强等优势,在欧洲有着较多的应用实例,但是在我国的应用非常有限。本文介绍了生物质混燃发电技术的发展现状、项目设计时要求注意的问题、国内外对生物质混燃发电项目的政策,分析了我国生物质混燃发电的发展障碍和解决方案,并提出了促进生物质混燃发展的意见和建议。 | 胡润青 秦世平 樊京春 Rachel Child Mike Bess | 2008 | 中国能源2008，30，5： | 9 |
| 8 | 城市与巢状等级显示文摘在看待全球化与城市的关系时,我们需要较为细致的眼光;需要一个框架来容纳世界主要城市间巨大的差异和越来越多的相似,既看到全球整合,也看到地方特色。我在文中基于巢状等级(nested hier- archy)原理,提出并解释了这样一个框架。笔者认为,城市处于组织方式各异的地区结构和国家体系相互依赖的世界秩序中。世界上的主要城市,其经济基础、空间组织和社会结构由各城市所在的整个多层结构——全球环境、地区结构、国家发展模式、本地历史语境——决定。整个地球的相互依赖越来越多,这与系统中地区、国家和城市各级之内以及之间的差异并不矛盾。城市作为全球秩序的组成部分,既推进了全球化进程,又各自有着相对自主的轨道。 | 理查德·柴尔德·希尔(Richard Child Hill) 黄觉(译) | 2005 | 国际社会科学杂志(中文版)2005，22，3： | 5 |
| 9 | Bilateral vs unilateral placement of metal stents for inoperable highgrade hilar biliary strictures: A systemic review and meta-analysis显示文摘BACKGROUND Bilateral vs unilateral biliary stenting is used for palliation in malignant biliary obstruction.No clear data is available to compare the efficacy and safety of bilateral biliary stenting over unilateral stenting.AIM To assess the efficacy and safety of bilateral vs unilateral biliary drainage in inoperable malignant hilar obstruction.METHODS PubMed,Embase,Scopus,and Cochrane databases,as well as secondary sources(bibliographic review of selected articles and major GI proceedings),were searched through January 2019.The primary outcome was the re-intervention rate.Secondary outcomes were a technical success,early and late complications,and stent malfunction rate.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated for each outcome.RESULTS A total of 9 studies were included(2 prospective Randomized Controlled Study,5 retrospective studies,and 2 abstracts),involving 782 patients with malignant hilar obstruction.Bilateral stenting had significantly lower re-intervention rate compared with unilateral drainage(OR=0.59,95%CI:0.40-0.87,P=0.009).There was no difference in the technical success rate(OR=0.7,CI:0.42-1.17,P=0.17),early complication rate(OR=1.56,CI:0.31-7.75,P=0.59),late complication rate(OR=0.91,CI:0.58-1.41,P=0.56)and stent malfunction(OR=0.69,CI:0.42-1.12,P=0.14)between bilateral and unilateral stenting for malignant hilar biliary strictures.CONCLUSION Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures,with no significant difference in technical success,and early or late complication rates. | Munish Ashat Sumant Arora Jagpal S Klair Christopher A Childs Arvind R Murali Frederick C Johlin | 2019 | World Journal of Gastroenterology2019，25，34： | 5 |
| 10 | 燃气轮机发动机内流及二次流系统(英文)显示文摘The challenging conditions at which gas turbine engines operate mean that careful management of component temperatures is necessary, in order to ensure component integrity and reasonable service life. Pressurised flows extracted from the compressor can be used for cooling, sealing and balancing of components throughout the engine. Cooling is typically necessary for some combustor and turbine components, and sealing flows may be needed to exclude high temperature gases. In addition to cooling and sealing requirements, there is also a need to balance thrust loads in an engine, to limit loads on bearings, arising from the pressure differentials across compressor and turbine disc assemblies. The diverse tasks of cooling, sealing and balancing are generally assigned to a system known as the internal air system or secondary flow system. This paper describes the technologies associated with this system for both industrial gas turbine engines and aero-engines, and the current state of the art and challenges in component and subsystem design. | Peter RN Childs | 2018 | 风机技术2018，60，6： | 4 |
| 11 | Fiber Laser Based Hydrophone Systems显示文摘我们报导我们分布式的反馈纤维激光上的最近的工作基于水中听音器。与敏感有关的一些问题例如纤维激光阶段状况,解调,并且包装,也被讨论。与适当数字信号处理(DSP ) 的发展技术和包装图案,一种 interferometric 类型散布了反馈(DFB ) 有 58.0 dB 敳獲? 慥档攠慮汢湩 ? 楤晦牥湥 ? 慭整楲污瀠潲散獳湩 ?敲楧敭 s | Asrul Izam AZMI Ian LEUNG Xiaobao CHEN Shaoling ZHOU Qing ZHU Kan GAO Paul CHILDS Gangding PENG | 2011 | Photonic Sensors2011，1，3： | 3 |
| 12 | Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immuno-contraceptive effect on mice显示文摘Lactate dehydrogenase C4 (LDHC4) is a key enzyme for sperm metabolism. It is distributed specifically in testis and is highly immunogenic. In this study, two DNA vaccines pVAX1-hLDHC and pVAX1-mLDHC were constructed by inserting coding sequences of human and mice LDHC4 into the eukaryotic ex-pression vector pVAX1. The production of LDHC4 specific antibodies was induced in the sera of vac-cinated mice and the reproductive tract secretions of vaccinated female mice through immunization by mucosal surface instillation. Furthermore, the antibody titer increased with the times of immunization. In the mating experiment, the number of newborns of the vaccinated mice reduced significantly and some immunized female mice even lost the ability to bear any offsprings, suggesting that the difference between the immunized and control mice was statistically significant. Sperm agglutination analysis indicated that both the antisera from immunized mice and the reproductive tract secretions of vacci-nated female mice could agglutinate normal sperms. Results of immunohistochemistry showed that the antibodies present in the sera of immunized mice and the reproductive tract secretions of vaccinated female mice could specifically react with LDHC4 antigen, which mainly locates in the cytoplasm, acrosome membrane externa and acrosome capsule of the sperm. Taken together, our results indicated that the constructed contraceptive DNA vaccines did yield immunocontraceptive effects on mice and this would enable clinical trials in near future. | CHEN Yong*, ZHANG Duo*, XIN Na, XIONG YongZhong, CHEN Ping, LI Bo, TU XiangDong & LAN FengHua Research Laboratory of Medical Genetics, PLA Institute of Technology for Birth Control, Fetal Health and Child Growth, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China | 2008 | Science China(Life Sciences)2008，51，4： | 3 |
| 13 | Spatial and temporal regulation of collagenases-3, -4,and stromelysin -3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosis显示文摘Matrix metalloproteinases (MMPs) are a family of extracellular proteases capable of degrading various proteinaceous components of the extracellular matrix (ECM).They have been implicated to play important roles in a number of developmental and pathological processes, such as tumor metastasis and inflammation. Relatively few studies have been carried out to investigate the function of MMPs during postembryonic organ-development. Using Xenopus laevis development as a model system, we demonstrate here that three MMPs, stromelysin-3 (ST3),collagenases-3 (Col3), and Col4, have distinct spatial and temporal expression profiles during metamorphosis as the tadpole transforms into a frog. In situ hybridizations reveal a tight, but distinct, association of individual MMPs with tissue remodeling in the tail and intestine during metamorphosis. In particular, ST3 expression is strongly correlated with apoptosis in both organs as demonstrated by analyses of serial sections with in situ hybridization for ST3 mRNA and TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin nick end labeling) for apoptosis, respectively. On the other hand, Col3 and Col4 MMPs in Xenopus laevis development are present in regions where extensive connective tissue remodeling take place. These results indicate that ST3 is likely to play a role in ECM-remodeling that facilitateapoptotic tissue remodeling or resorption while Col3 and Col4 appear to participate in connective tissue degradation during development. | DAMJANOVSKI SASHKO ATSUKO ISHIZUYAOKA YUN-BO SHI (Laboratory of Molecular Embryology, Building 18T, Rm. 106, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA)(Department Of Histology and | 1999 | Cell Research1999，9，2： | 3 |
| 14 | Risk Factors of Learning Disabilities in Chinese Children in Wuhan显示文摘Objective To investigate prevalence rate of learning disabilities (LD) in Chinese children, and to explore related risk factors, and to provide theoretical basis for preventing such disabilities.Methods One thousand and one hundred fifty one children were randomly selected in primary schools. According to criteria set by ICD-10, 118 children diagnosed as LD were classified into the study group. Four hundred and ninety one children were classified into the normal control group. Five hundred and forty two children were classified into the excellent control group. The study instruments included PRS (The pupil rating scale revised screening for learning disabilities), Conners' children behavior check-list taken by parents and YG-WR character check-list. Results The prevalence rate of LD in Chinese children was 10.3%. Significant differences were observed between LD and normally learning children, and between the LD group and the excellent group, in terms of scores of Conners' behavior check-list (P<0.05). The study further showed that individual differences in character between the LD group and the control groups still existed even after controlling individual differences in age, IQ, and gender. Some possible causal explanations contributing to LD were improper teaching by parents, low educational level of the parents, and children's characteristics and social relationships. Conclusion These data underscore the fact that LD is a serious national public health problem in China. LD is resulted from a number of factors. Good studying and living environments should be created for LD children. | BIN YAO AND HAN-RONG WUDepartment of Children and Adolescent Health, Maternity and Child Health Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China | 2003 | Biomedical and Environmental Sciences2003，16，4： | 2 |
| 15 | Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society显示文摘 | Elizabeth R. Seaquist John Anderson Belinda Childs Philip Cryer Samuel Dagogo-Jack Lisa Fish Simon R. Heller Henry Rodriguez James Rosenzweig Robert Vigersky | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，5： | 2 |
| 16 | A Relocation-based Initialization Scheme to Improve Track-forecasting of Tropical Cyclones显示文摘A relocation procedure to initialize tropical cyclones was developed to improve the representation of the initial conditions and the track forecast for Panasonic Weather Solutions Tropical Operational Forecasts. This scheme separates the vortex perturbation and environment field from the first guess, then relocates the initial vortex perturbations to the observed position by merging them with the environment field. The relationships of wind vector components with stream function and velocity potential are used for separating the vortex disturbance from first guess. For the separation of scalars, a low-pass Barnes filter is employed. The irregular-shaped relocation area corresponding to the specific initial conditions is determined by mapping the edge of the vortex radius in 36 directions.Then, the non-vortex perturbations in the relocation area are removed by a two-pass Barnes filter to retain the vortex perturbations, while the variable fields outside the perimeter of the modified vortex are kept identical to the original first guess. The potential impacts of this scheme on track forecasts were examined for three hurricane cases in the 2011–12 hurricane season. The experimental results demonstrate that the initialization scheme is able to effectively separate the vortex field from the environment field and maintain a relatively balanced and accurate relocated first guess. As the initial track error is reduced, the following track forecasts are considerably improved. The 72-h average track forecast error was reduced by 32.6% for the cold-start cases, and by 38.4% when using the full-cycling data assimilation because of the accumulated improvements from the initialization scheme. | GAO Feng Peter P. CHILDS Xiang-Yu HUANG Neil A. JACOBS Jinzhong MIN | 2014 | Advances in Atmospheric Sciences2014，31，1： | 2 |
| 17 | The effect of inlet conditions on the flow and heat transfer in multiple rotating cavity with axial throughflow显示文摘 | Christopher Long Peter Childs | 2007 | 航空动力学报2007，22，5： | 2 |
| 18 | Nutritional value of dried algae diets for larvae of manila clam (Tapes philippinarum)显示文摘 | Laing I Child A R Janke A | 1990 | J Mar Boil Ass1990，70，： | 2 |
| 19 | Reductive acid leaching of laterite and metal oxides — A review with new data for Fe(Ni,Co)OOH and a limonitic ore显示文摘 | G. Senanayake J. Childs B.D. Akerstrom D. Pugaev | 2011 | Hydrometallurgy2011，，1： | 2 |
| 20 | Neuronal nitric oxide synthase and ischemia--induced neurogenesis显示文摘 | Sun Y Jin K Childs JT | 2005 | Cereb Blood Flow Metab2005，25，： | 1 |
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