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| 1 | Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens显示文摘AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group. | Marcos Eduardo Lera dos Santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz Thiago Ferreira de Souza Fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai | 2013 | World Journal of Gastroenterology2013，19，22： | 16 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Alterations in car- bon and nitrogen metabolism induced by water deficit in the stems and leaves of Lupinus albus L显示文摘 | PINHEIRO C CHAVES M M RICARDO C P | 2001 | Journal of Experimental Botany2001，52，： | 1 |
| 4 | Photosynthesis underdrought and salt stress:Regulation mechanisms from whole plant to cell 显示文摘 | CHAVES M M FLEXAS J PINHEIRO C | 2009 | Annals of Botany2009，103，： | 1 |
| 5 | Functional neuroimaging of minocycline' s effect in a patient with schizophrenia显示文摘 | Chaves C de Marque CR Wichert-Ana L | 2010 | Prog Neuropsychopharmacol Biol Psychiatry2010，34，： | 1 |
| 6 | High-efficiency LED backlight optics designed with the flow-line method显示文摘 | MINANO J C BEN(I)TEZ P CHAVES J | | 0，，： | 1 |
| 7 | Tree allometry and improved estimation of carbon stocks and balance in tropical forests显示文摘 | Chave J Andalo C Brown S Cairns M A Chambers J Q Eamus D Folster H Fromard F Higuchi N Kira T Lescure J P Nelson B W Ogawa H Puig H Riera B Yamakura T | | 0，，： | 1 |
| 8 | A reversible posterior leukoencephalopathy syndrome显示文摘 | Hinchey J Chaves C Appignani B | 1996 | N Engl Med1996，334，8： | 1 |
| 9 | A reversible posterior leukoencephalopathy syndrome显示文摘 | Hinchey J Chaves C Appignani B | 1996 | N Engl J Med1996，334，： | 1 |
| 10 | Agdcultural use of sediments from the Albufera Lake(eastern Spain)显示文摘 | Canet R Chaves C Pomares F | 2003 | Agriculture Ecosystems and Environment2003，95，： | 1 |
| 11 | Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the on set of infection 显示文摘 | Barquero C Chaves E Weiss D S | 2007 | PloS One2007，2，7： | 1 |
| 12 | Dif- ferential moduIation of ATP-induced P2XT-associated permeabilities to cations and anions of macrophages by in- fection with leishmania amazonensis显示文摘 | Marques-da-Silva C Chaves MM Rodrigues JC | 2011 | PLoS One2011，6，25： | 1 |
| 13 | Henoch-Schonlein purpura follow- ing hepatitis B vaccination 显示文摘 | Chave T Neal C Camp R | 2003 | J Dermatol Treat2003，14，3： | 1 |
| 14 | Controlled electromagnetic sources for measuring electrical conductivity beneath the oceans, 1 : Forward problem and model study显示文摘 | Chave A D Cox C S | 1982 | Journal of Geophysical Research1982，87，7： | 1 |
| 15 | A reversible posterior lou- koenccphalopathy syndrome 显示文摘 | Hinchey J Chaves C Appignani B | 1996 | N Engl J Med1996，334，13： | 1 |
| 16 | Lipolysis, proteolysis and sensory characteristics of a Spanish fermented dry - cured meat product ( salchichon ) with oregano essential oil used as surface mold inhibitor 显示文摘 | Matin - Sanchez AM Chaves - lopez C Sendra E | 2011 | Meat Science2011，89，1： | 1 |
| 17 | Controlled source electromagnetic sounding of the oceanic lithosphere显示文摘 | Cox C S Constable S Chave A D | 1986 | Nature1986，320，1： | 1 |
| 18 | Molecular identification and osmotolerant profile of wine yeasts that ferment a high suger grape must 显示文摘 | Tofalo R Chaves - Lopez C Di Fabio F | 2009 | Int J Food Microbio12009，130，3： | 1 |
| 19 | A reversible posterior 1eukoencephalopathy syndrome显示文摘 | Hinche J Chaves C Appignani B | | 0，，08： | 1 |
| 20 | A reversible posterior leukoencephalopathy syndrome显示文摘 | Hinchey J Chaves C Appignani B | | 0，，08： | 1 |
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