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| 1 | How we can improve patients’comfort after Milligan- Morgan open haemorrhoidectomy显示文摘AIM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of post-haemorhoidectomic symptoms.METHODS:Eighty-six consecutive patients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital,Xinjiang Medical University from April 2009 to April 2010,were enrolled in this study.An observerblinded,randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs placebo.Eighty-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk(n=43)or placebo(n=43).The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision method.Pain,bleeding,heaviness,pruritus,wound edema and mucosal discharge were observed after surgery.The postoperative symptoms and hospitalization time were recorded.RESULTS:The mean age of the Diosmin group and controls was 53.2 and 51.3 years,respectively.In Diosmin group,haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10;and in the control group,29 were of the third degree and 14 were of the fourth degree.There was no statistically significance in age,gender distribution,degree and number of excised haemorrhoid piles,and the mean duration of haemorrhoidal disease between the two groups.There was a statistically significant improvement in pain,heaviness,bleeding,pruritus from baseline to the 8th week after operation(P<0.05).Patients taking Diosmin had a shorter hospitalization stay after surgery(P< 0.05).There was also a significant improvement on the proctoscopic appearance(P<0.001).However,there was no statistical difference between the two groups in terms of wound mucosal discharge.Two patients experienced minor bleeding at the 8th week in Diosmin group,and underwent surgery.CONCLUSION:Diosmin is effective in alleviating postoperational symptoms of haemorrhoids.Therefore,it should be considered for the initial treatment after haemorrhoid surgery.However,further prospective randomized trials are needed to confirm the findings of this study. | Ma-Mu-Ti-Jiang A ba-bai-ke-re Hong-Guo Huang Wen-Ni Re Kai Fan Hui Chu Er-Ha-Ti Ai Mai-Mai-Ti-Tu-Er-Xun KE Li-Mu Yi-Rui Wang Hao Wen | 2011 | World Journal of Gastroenterology2011，17，11： | 13 |
| 2 | Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for complex anorectal fistula显示文摘AIM: To compare the efficacy and safety of acellular dermal matrix (ADM) bioprosthetic material and endorectal advancement flap (ERAF) in treatment of complex anorectal fistula. METHODS: Ninety consecutive patients with complex anorectal fistulae admitted to Anorectal Surgical Department of First Affi liated Hospital, Xinjiang Medical University from March 2008 to July 2009, were enrolled in this study. Complex anorectal fistula was diagnosed following its clinical, radiographic, or endoscopic diagnostic criteria. Under spinal anesthesia, patients underwent identification and irrigation of the fistula tracts using hydrogen peroxide. ADM was securely sutured at the secondary opening to the primary opening using absorbable suture. Outcomes of ADM and ERAF closure werecompared in terms of success rate, fecal incontinence rate, anorectal deformity rate, postoperative pain time, closure time and life quality score. Success was defined as closure of all external openings, absence of drainage without further intervention, and absence of abscess formation. Follow-up examination was performed 2 d, 2, 4, 6, 12 wk, and 5 mo after surgery, respectively. RESULTS: No patient was lost to follow-up. The overall success rate was 82.22% (37/45) 5.7 mo after surgery. ADM dislodgement occured in 5 patients (11.11%), abscess formation was found in 1 patient, and fistula recurred in 2 patients. Of the 13 patients with recurrent fistula using ERAF, 5 (11.11%) received surgical drainage because of abscess formation. The success rate, postoperative pain time and closure time of ADM were significantly higher than those of ERAF (P < 0.05). However, no difference was observed in fecal incontinence rate and anorectal deformity rate after treatment with ADM and ERAF. CONCLUSION: Closure of fistula tract opening with ADM is an effective procedure for complex anorectal fistula. ADM should be considered a first line treatment for patients with complex anorectal fistula. | Ma-Mu-Ti-Jiang A ba-bai-ke-re Er-Ha-Ti Ai | 2010 | World Journal of Gastroenterology2010，16，26： | 10 |
| 3 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 4 | Physicochemicai properties of caseinstarch interaction obtained by extrusion process显示文摘 | FERNANDEZ-GUTIERRES J A MARTIN-MARTfNEZ E S MARTINEZ-BUSYOS F et ai | 2004 | Starch2004，56，： | 1 |
| 5 | A placebo - controlled comparison of the efficiency of triple and monotherapy in category Ⅲb chronic pelvic pain syndrome ( CPPS ) 显示文摘 | Tugcu V Tasci AI Fazlioglu A | 2007 | Eururol2007，51，4： | 1 |
| 6 | Foodborne Botulism in the United States显示文摘 | Sobel J Tucker N Sulka A et aI | 2004 | Emerg Infect Dis2004，10，： | 1 |
| 7 | UKPDS 59:hyperglycemia and other potentially modifiable risk factors for peripheral vascular disease in type 2 diabetes显示文摘 | Stevens RJ Neil A | 2002 | Diabetes Care2002，25，： | 1 |
| 8 | l Frequency and determi-nants of postprocedural hemodynamic instability after carotid angio-plasty and stenting显示文摘 | Qureshi AI Luft AR SharmaM et a | 1999 | Stroke1999，30，： | 1 |
| 9 | TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and nnmutated chronic lymphocytic leukemia显示文摘 | Raval A Lueas D M MatkovicJ J et aI | 2005 | J Clin Oncol2005，23，17： | 1 |
| 10 | POEMS syndrome:definitions and long-term outcome显示文摘 | Dispenzieri A Kyle RA Lacy MQ et ai | 2003 | Blood2003，101，7： | 1 |
| 11 | Continuous lateral rotation therapy to prevent ventilator-associated pneumonia显示文摘 | Staudinger T Bojie A Holzinger U et aI | 2010 | Crit Care Med2010，38，2： | 1 |
| 12 | Ethics and ethos: The buffering and amplifying effects of ethical behavior and virtuousness显示文摘 | Caza A et aI | 2004 | Journal of Bus- iness Ethics2004，52，2： | 1 |
| 13 | Proteome analysis of conditioned medium from cultured adult hippocampal pregenitors显示文摘 | Dahl A Eriksson PS Rersson AI | 2003 | Rapid Commun Mass Sp2003，17，19： | 1 |
| 14 | Comparison of the effects of ovarian cauterization and gonadotropin-releasing-hormone agonist and oral contraceptive therapy combination on endocrine changes in women with Polycystic ovary disease显示文摘 | Taskin O Yalcinoglu AI Kafkasli A | 1996 | Fertil Steril1996，65，6： | 1 |
| 15 | Solution structure of a conserved C - terminal domin of p73 with structural homology to the SAM domain显示文摘 | Chi SW Ayed A | 1999 | EMBO1999，18，： | 1 |
| 16 | Foreign body aspiration in children:Diagnosis and treatment显示文摘 | Ayed AK Jafar AM Owayed A | 2003 | Pediatr Surg Int2003，19，： | 1 |
| 17 | Plasma homocysteine as a risk factor for dementia and Aizheimer' s disease显示文摘 | Seshadri S Beiser A Seihub J et ai | 2002 | N Engi J Med2002，346，： | 1 |
| 18 | Clopidogrel for coronary stenting response variability, drug resistance, and the effect of pretreatment platelet reactivity显示文摘 | PAUL A C KEVIN P B BONNIE L H et aI | 2003 | Circulation2003，107，： | 1 |
| 19 | Biomarkers for insulin resistance and inflammation and the risk for all - cause demen- tia and alzheimer disease: results from the framingham heart study 显示文摘 | VAN HIMBERGEN T M BEISER A S AI M | 2012 | Arch Neural2012，，： | 1 |
| 20 | CT arteriography and venography Jn puIsatiIe tinnitus:prelimfnary results显示文摘 | Krishnan A N1attox DE Fountain AJ et aI | 2006 | AJNR Am J NeuroradioI2006，27，8： | 1 |
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