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| 1 | Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina Ⅱ Neurons显示文摘Previous studies have shown that CCL2(C-C motif chemokine ligand 2)induces chronic pain,but the exact mechanisms are still unknown.Here,we established models to explore the potential mechanisms.Behavioral experiments revealed that an antagonist of extracellular signal-regulated kinase(ERK)inhibited not only CCL2-induced inflammatory pain,but also pain responses induced by complete Freund’s adjuvant.We posed the question of the intracellular signaling cascade involved.Subsequent experiments showed that CCL2 up-regulated the expression of phosphorylated ERK(pERK)and N-methyl D-aspartate receptor[NMDAR]subtype 2B(GluN2B);meanwhile,antagonists of CCR2 and ERK effectively reversed these phenomena.Whole-cell patchclamp recordings revealed that CCL2 enhanced the NMDAR-induced currents via activating the pERK pathway,which was blocked by antagonists of GluN2B and ERK.In summary,we demonstrate that CCL2 directly interacts with CCR2 to enhance NMDAR-induced currents,eventually leading to inflammatory pain mainly through the CCL2-CCR2-pERK-GluN2B pathway. | Hui Zhang Sui-Bin Ma Yong-Jing Gao Jun-Ling Xing Hang Xian Zhen-Zhen Li Shu-Ning Shen Sheng-Xi Wu Ceng Luo Rou-Gang Xie | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 2 | High-speed third rail shoegear 显示文摘 | Hartland D J CEng MA MIMechE MIEE | 1995 | Journal of Rail and Rapid Transit1995，209，： | 1 |
| 3 | 防爆柴油机在井下煤矿应用中的设计特性和操作经验[J]显示文摘 | JANCurrie MA Ceng | | 力量与能量0，，： | 1 |
| 4 | Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission显示文摘Tweety-homolog 1(Ttyh1)is expressed in neural tissue and has been implicated in the generation of several brain diseases.However,its functional significance in pain processing is not understood.By disrupting the gene encoding Ttyh1,we found a loss of Ttyh1 in nociceptors and their central terminals in Ttyh1-deficient mice,along with a reduction in nociceptor excitability and synaptic transmission at identified synapses between nociceptors and spinal neurons projecting to the periaqueductal grey(PAG)in the basal state.More importantly,the peripheral inflammationevoked nociceptor hyperexcitability and spinal synaptic potentiation recorded in spinal-PAG projection neurons were compromised in Ttyh1-deficient mice.Analysis of the paired-pulse ratio and miniature excitatory postsynaptic currents indicated a role of presynaptic Ttyh1 from spinal nociceptor terminals in the regulation of neurotransmitter release.Interfering with Ttyh1 specifically in nociceptors produces a comparable pain relief.Thus,in this study we demonstrated that Ttyh1 is a critical determinant of acute nociception and pain sensitization caused by peripheral inflammation. | Wen-Juan Han Sui-Bin Ma Wen-Bin Wu Fu-Dong Wang Xiu-Li Cao Dong-Hao Wang Hai-Ning Wu Rou-Gang Xie Zhen-Zhen Li Fei Wang Sheng-Xi Wu Min-Hua Zheng Ceng Luo Hua Han | 2021 | Neuroscience Bulletin2021，37，4： | 1 |
| 5 | Research Progress and Application Prospect of IPS Cells显示文摘Differentiated somatic cells can be reprogrammed into induced pluripotent stem cells (iPS cells) by introducing specific transcription factors. This technique avoids immune rejection and ethical problems in stem cell research. A great revolution in the fi eld of science. As with embryonic stem cells (ES cells), iPS cells are able to self-renew and maintain undiff erentiated state. In vitro, iPS cells can be induced to diff erentiate into a variety of mature cells, therefore, iPS cells in theoretical research and clinical applications are extremely valuable. IPS cell diff erentiation and transplantation in the treatment of blood diseases have a great use, iPS cells can treat nervous system diseases, to provide in vitro disease model, to study the mechanism of disease formation, screening new drugs and the development of new to provide a new treatment The The use of iPS cells as a nuclear donor cell, with the appropriate receptor cells after fusion can be directly obtained transgenic animals. Not only can improve the genetic nature of animals, but also can break the boundaries of species and get the new animal traits that cannot achieve by using traditional mating methods. The research of iPS cells has been widely concerned, and it is the research hotspot in cell biology and molecular biology. In this paper, the defi nition of iPS cells, the acquisition of iPS cells, the history of development, the signifi cance of research, the progress of research, the application of iPS cells, and the problems of iPS cells were reviewed. | Yiwu Ceng Huanhuan Ma Jiaying Deng Zihao Chen Hao Li | 2017 | Gene Science & Engineering2017，1，1： | 0 |
| 6 | Spherical quantum dot in modified Kratzer-Coulomb potential:study of optical rectification coefficients显示文摘We consider the effects of quantum dot radius,confinement potential depth and controllable effective mass on the optical rectification coefficient(ORC)in spherical quantum dots,which is confined with Modified Kratzer-Coulomb Potential(MKCP).Using the Nikiforov-Uvarov method and compact density matrix theory,the ground state energy,ORC and wave function of electrons under the combined action of many factors are calculated.The results show that they affect the optical rectification response from different angles,including the position of peak and formant. | Xuechao Li Ceng Chang Yongrui Ma | 2022 | Communications in Theoretical Physics2022，74，6： | 0 |
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