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| 1 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 2 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 3 | Anacne grading metbod using pholographic standards显示文摘 | Cook CH Centner RL Michaels SE | 1979 | Arch Derma- tol1979，115，5： | 1 |
| 4 | Developing institutions to encourage the use of animal wastes as production inputs显示文摘 | Terence J. centner | 2004 | Agriculture and Human Values2004，，4： | 1 |
| 5 | The NH2 terminus of titin spans the Z-disc:Its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integri- ty显示文摘 | GREGORIO C C TROMBITAS K CENTNER T | 1998 | Cell Biol1998，143，： | 1 |
| 6 | Unfinished business in the regulation of shale gas production in the United States显示文摘 | Centner T J O’Connell L K | 2014 | Science of the Total Environment2014，，35： | 1 |
| 7 | An acne grading method using photographic standards 显示文摘 | Cook CH Centner RL Michaels SE | 1979 | Arch Dermatol1979，115，5： | 1 |
| 8 | Elimination of uninformative variables for multivariate calibration 显示文摘 | Centner V Massart D L de Noord O E | 1996 | Anal Chem1996，，68： | 1 |
| 9 | Impact of various endo-crine and paracrine factors on in vitro culture of preantral folliclesin rodents显示文摘 | Demeestere I Centner J Gervy C | 2005 | Reproduction2005，130，2： | 1 |
| 10 | The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system显示文摘 | BANG M L CENTNER T FORNOFF F | 2001 | Circ Res2001，89，11： | 1 |
| 11 | Characterization of human palladin, a microfilament associated protein显示文摘 | BANG M L CENTNER T FORNOFF F | 2001 | Mol Biol Cell2001，12，10： | 1 |
| 12 | The NH2 terminus of titin spans the Z-disc: Its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integri- ty显示文摘 | GREGORIO C C TROMBITS K CENTNER T | 1998 | Cell Biol1998，143，： | 1 |
| 13 | Elimination of uninformative variables for multivariate calibration显示文摘 | CENTNER V MASSART D DENOORS O E | 1996 | Analytical Chemistry1996，68，21： | 1 |
| 14 | New state liability exceptions, for agritourism activities and the use of liability release显示文摘 | Centner T J | 2009 | Agriculture and Human Values2009，26，3： | 1 |
| 15 | Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain显示文摘 | Centner T Yano J Kimura E | 2001 | J Mol Biol2001，306，： | 1 |
| 16 | Nationof uninformative variables for multivariate calibration显示文摘 | Centner V Massart DL deNoord OE | 1996 | Analytical Chemistry1996，68，： | 1 |
| 17 | I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure显示文摘 | Rudy D E Centner T | 1999 | J Cell Biol1999，146，： | 1 |
| 18 | Discerning Public Participation Require-ments Under the US Clean Water Act显示文摘 | CENTNER T J | 2010 | Water Resources Management2010，24，10： | 1 |
| 19 | Elimination of uninformative variables for mutivariate calibration显示文摘 | Centner V Massart DL de Noord OE De Jong S Vandeginste BM Stema C | 1996 | Anal Ghem1996，68，21： | 1 |
| 20 | Nation of uninformative variables for multivariate calibration 显示文摘 | Centner V Massart D L deNoord O E | 1996 | Anal Chem1996，68，： | 1 |
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