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| 1 | Phase I , pharmacokinetic, and DCE-MRI correlative study of AVE8062A, an antivascular combretastatin analogue, administered weekly for 3 weeks every 28 days 显示文摘 | TOLCHER A W FORERO L CELIO P | 2003 | Proc Am Soc Clin Oncol2003，22，9： | 1 |
| 2 | Impact of cognitive reserve on the relationship of lead exposure and neurobehavioral performance 显示文摘 | Bleecker M L Ford D P Celio M A | 2007 | Neurology2007，69，5： | 1 |
| 3 | Phase I , pharmacokinetic, and DCE-MRI correlative study of AVES062A, an antivascular combretastatin analogue, administered weekly for 3 weeks every 28 days 显示文摘 | Tolcher AW Forero L Celio P | 2003 | J Clin Oncol2003，，： | 1 |
| 4 | Cardiac ischemia model for + Gz using miniature swine and baboons显示文摘 | Burns J W Kruyer W B Celio P V | 2008 | Aviat Space Environ Med2008，79，4： | 1 |
| 5 | Identification of counterfeit drugs using near infrared spectroscopy显示文摘 | SERGIO H FRASSON S CELIO P | 2001 | Analyst2001，，126： | 1 |
| 6 | A PLS regression model using NIR spectroscopy for on-line monitoring of the biodiesel production reaction显示文摘 | Mario H M K Jarbas J R R Celio P | 2011 | Fuel2011，90，： | 1 |
| 7 | Farmers' perception of their decision-making in relation to policy schemes: A comparison of case studies from Switzerland and the United States显示文摘 | Celio E Flint C G Schoch P | 2014 | Land Use Policy2014，41，6： | 1 |
| 8 | Improving the stability ofnano- structured silicon thin film lithium -ion battery anodes through their controlled oxidation 显示文摘 | ABEL P R LIN Y M CELIO H | 2012 | ACS Nano2012，6，3： | 1 |
| 9 | Sensitivi- ty of Venturia inaequolis to Trifloxystrobin and Difenoconazole in Uruguay显示文摘 | Mondino P Casanova L Celio A | 2015 | Journal of Phy- topathology2015，163，1： | 1 |
| 10 | Eldfellite,Na Fe(SO4)2:An intercalation cathode host for low-cost Na-ion batteries显示文摘 | SINGH P SHIVA K CELIO H | 2015 | Energy&Environmental Science2015，8，10： | 1 |
| 11 | Eldfellite, NaFe(SO4)2: an intercalation cathode host for low-cost Na-ion batter- ies显示文摘 | Singh P Shiva K Celio H | 2015 | Energy & Environmental Science2015，8，10： | 1 |
| 12 | Improving the stability of nanostructured silicon thin film lithium-ion battery anodes through their controlled oxidation显示文摘 | Abel P R Lin Y M Celio H | 2012 | ACS Nano2012，6，3： | 1 |
| 13 | The natural history of minimal coronary artery disease in US air force aviators : 1971-1989 显示文摘 | MaGranahan G M Munson R A Celio P V | 1993 | Aviat Space Environ Med1993，64，5： | 1 |
| 14 | Comminution of silicon carbide powder in a planetary mill显示文摘 | MARIA Aparecida P DOS Santos CELIO A Costa | 2006 | Powder Technol2006，169，： | 1 |
| 15 | B-1 cells modulate the murine macrophage response to Leishmania major infection显示文摘AIM To investigate the modulatory effect of B-1 cells on murine peritoneal macrophages infected with Leishmania major(L. major) in vitro.METHODS Peritoneal macrophages obtained from BALB/c andBALB/c XID mice were infected with L. major and cultured in the presence or absence of B-1 cells obtained from wild-type BALB/c mice. Intracellular amastigotes were counted, and interleukin-10(IL-10) production was quantified in the cellular supernatants using an enzymelinked immunosorbent assay. The levels of the lipid mediator prostaglandin E2(PGE2) were determined using a PGE2 enzyme immunoassay kit(Cayman Chemical, Ann Arbor, MI), and the number of lipid bodies was quantified in the cytoplasm of infected macrophages in the presence and absence of B-1 cells. Culturing the cells with selective PGE2-neutralizing drugs inhibited PGE2 production and confirmed the role of this lipid mediator in IL-10 production. In contrast, we demonstrated that B-1 cells derived from IL-10 KO mice did not favor the intracellular growth of L. major.RESULTS We report that B-1 cells promote the growth of L. major amastigotes inside peritoneal murine macrophages. We demonstrated that the modulatory effect was independent of physical contact between the cells, suggesting that soluble factor(s) were released into the cultures. We demonstrated in our co-culture system that B-1 cells trigger IL-10 production by L. major-infected macrophages. Furthermore, the increased secretion of IL-10 was attributed to the presence of the lipid mediator PGE2 in supernatants of L. major-infected macrophages. The presence of B-1 cells also favors the production of lipid bodies by infected macrophages. In contrast, we failed to obtain the same effect on parasite replication inside L. major-infected macrophages when the B-1 cells were isolated from IL-10 knockout mice. CONCLUSION Our results show that elevated levels of PGE2 and IL-10 produced by B-1 cells increase L. major growth, as indicated by the number of parasites in cell cultures. | Angelica F Arcanjo Marise P Nunes Elias B Silva-Junior Monique Leandro Juliana Dutra Barbosa da Rocha Alexandre Morrot Debora Decote-Ricardo Celio Geraldo Freire-de-Lima | 2017 | World Journal of Biological Chemistry2017，8，2： | 0 |
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