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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | A carrier-based PWM strategy with zero-sequence voltage injection for a three-level neutral-point-clamped converter显示文摘 | Pou J Zaragoza J Ceballos S | 2012 | IEEE Transactions on Power Electronics2012，27，2： | 1 |
| 3 | Dam reservoir eutrophication:A simplified technique for a fast diagnosis of envimnmental degradation 显示文摘 | CEBALLOS R S KONG A OLIVERRA J F | 1998 | Water Res1998，32，： | 1 |
| 4 | A greenhouse screening technique for acid soil tolerance in maize显示文摘 | Urrea-Gomez R Ceballos H Pandey S Bahia-Filho A F C Leon L A | 1996 | Agron J1996，88，： | 1 |
| 5 | Chemoprophylactic activity of flubendazole in cystic echinococcosis显示文摘 | Ceballos L Elissondo C Sanchez Bruni S | 2011 | Antimicrobial Agents and Chemotherapy2011，55，： | 1 |
| 6 | Prediction of carotenoids, cyanide and dry matter contents in fresh cassava root using NIRS and Hunter color techniques显示文摘 | T. Sánchez H. Ceballos D. Dufour D. Ortiz N. Morante F. Calle T. Zum Felde M. Domínguez F. Davrieux | 2014 | Food Chemistry2014，，： | 1 |
| 7 | Dam reservoireutrophieation: A simplified technique for a fast diagnosis of envimnmentaldegradation 显示文摘 | CEBALLOS R S KONIG A OLIVERRA J F | 1998 | Water Res1998，32，： | 1 |
| 8 | Effects of environmental factors and nutrient availability on the biochemical composition of algae for biofuels production: a review 显示文摘 | Juneja A Ceballos R M Murthy G S | 2013 | Energies2013，6，9： | 1 |
| 9 | River water quality improvement by natural and constructed wetland systems in the tropical semi-arid region of Northeastern Brazil 显示文摘 | De Ceballos B S O Oliveira H Meira C M B S | 2001 | Wat Sci Tech2001，44，1112： | 1 |
| 10 | Hydrological behaviour of a small catchment in the dehesa landuse system (Extremadura, SW Spain) 显示文摘 | Ceballos A Schnabel S | 1998 | Journal of Hydrology1998，210，14： | 1 |
| 11 | Composition of goat and cow milk produced under similar conditions and analyzed by identical methodology 显示文摘 | Ceballos L S Morales E R de la Torre Adarve G | 2009 | J Food Compos Anal2009，22，4： | 1 |
| 12 | A carrier-based PWM strategy with zero-sequence voltage injection for a three-level neutral- point-clamped converter显示文摘 | Pou J Zaragoza J Ceballos S | 2012 | IEEE Transactions on Power Electronics2012，27，2： | 1 |
| 13 | Tribological behaviour of line hardening of steel U13A with Nd : YAG laser显示文摘 | Sagaro R Ceballos J S Blanco A | 1999 | Wear1999，，： | 1 |
| 14 | A green- house screening technique for acid soil tolerance in maize显示文摘 | URREA-GOMEZ R CEBALLOS E PANDEY S | 1996 | Agron J1996，88，5： | 1 |
| 15 | ziver water quality improvement by natural and constructed wetland systems in the tropical semi-arid region of Northeastern Brazil显示文摘 | H Oliveira C M B S Meira | 2001 | Water Sci Technol2001，44，1112： | 1 |
| 16 | Active redundant submodule configuration in modular multilevel converters 显示文摘 | Konstantinou G Pou J Ceballos S | 2013 | IEEE Transactions on Power Delivery2013，28，4： | 1 |
| 17 | Tribological behaviour of line hardening of steel U13A with Nd:YAG laser显示文摘 | Sagaro R Ceballos J S Mascarell J | 1999 | Revista de Metalurgia (Madrid)1999，35，3： | 1 |
| 18 | A comprehensive study of a hybrid modulation technique for the neutral-point-clamped converter 显示文摘 | ZARAGOZA J POU J CEBALLOS S | 2009 | IEEE Tran Ind Electron2009，56，2： | 1 |
| 19 | Dam reservoir eutrophication:A simplified technique for a fast diagnosis of environmental degradation显示文摘 | KONIG A OLIVERRA J F | 1998 | Water Res1998，32，： | 1 |
| 20 | Different diatoms induce contras- ting effects on the reproductive success of the copepod Temora stylifera 显示文摘 | Ceballos S Ianora A | 2003 | J Exp Mar Biol Ecol2003，294，2： | 1 |
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