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| 1 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 2 | Enhanced dissolution and systemic availability of albendazole formulated as solid dispersions显示文摘 | Silvina G. Castro Sergio F. Sanchez Bruni Lucí a P. Urbizu Alejandra Confalonieri Laura Ceballos Carlos E. Lanusse Daniel A. Allemandi Santiago D. Palma | 2013 | Pharmaceutical Development and Technology2013，，2： | 2 |
| 3 | Histamine improves anti-gen uptake and cross-presentation by dendritic cells 显示文摘 | Amaral M M Davio C Ceballos A | 2007 | J Immu-nol2007，179，6： | 1 |
| 4 | Dam reservoir eutrophication:A simplified technique for a fast diagnosis of envimnmental degradation 显示文摘 | CEBALLOS R S KONG A OLIVERRA J F | 1998 | Water Res1998，32，： | 1 |
| 5 | Determination of the axial 'force on stay cables accounting for their bending stiffness and rotational end restraints by free vibration tests 显示文摘 | CEBALLOS M A PRATO C A | 2008 | Journal of Sound and Vibration2008，317，4： | 1 |
| 6 | Temporal stability of soil moisture in a large-field experiment in Spain 显示文摘 | Martinez-Fernandez J Ceballos A | 2003 | Soil Science Society of America Journal2003，67，6： | 1 |
| 7 | A greenhouse screening technique for acid soil tolerance in maize显示文摘 | Urrea-Gomez R Ceballos H Pandey S Bahia-Filho A F C Leon L A | 1996 | Agron J1996，88，： | 1 |
| 8 | Determination of axial force on stay cables accounting for their bending stiff- ness and rotational end restraints by free vibration tests 显示文摘 | Ceballos M A Prato C A | 2008 | Journal of Sound and Vibration2008，，317： | 1 |
| 9 | Influence of formulalion and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets 显示文摘 | CEBALLOS A CIRRI M MAESTRELLI F | 2005 | Famoco2005，60，1112： | 1 |
| 10 | Dam reservoireutrophieation: A simplified technique for a fast diagnosis of envimnmentaldegradation 显示文摘 | CEBALLOS R S KONIG A OLIVERRA J F | 1998 | Water Res1998，32，： | 1 |
| 11 | Effects of environmental factors and nutrient availability on the biochemical composition of algae for biofuels production: a review 显示文摘 | Juneja A Ceballos R M Murthy G S | 2013 | Energies2013，6，9： | 1 |
| 12 | Randomized controlled pilot trial of yoga in overweight and obese breast cancer survivors: effects on quality of life and anthropometfic measures 显示文摘 | Littman A J Bertram LC Ceballos R | 2012 | Support Care Cancer2012，20，2： | 1 |
| 13 | Somatic cell count in milk of selenium-supplemented dairy cows after an intramammary challenge with Staphylococcus aureus显示文摘 | Kruze J Ceballos A Stryhn H | 2007 | Vet Med A Physiol Pathol Clin Med2007，54，9： | 1 |
| 14 | Sister chromatid exchanges,Proliferating rate index,and Micronuclei in biomonitoring of internal exposure to vinyl chloride monomer in plastic industry workers显示文摘 | Sinues B Sanz A Bernal ML Tres A Alcala A Lanuza J Ceballos C and Saenz MA | 1991 | Toxicology and applied pharmacology1991，108，： | 1 |
| 15 | Hydrological behaviour of a small catchment in the dehesa landuse system (Extremadura, SW Spain) 显示文摘 | Ceballos A Schnabel S | 1998 | Journal of Hydrology1998，210，14： | 1 |
| 16 | Determination of the axial force onstay cables accounting for their bending stiffness and rotational end restraints by free vibration tests 显示文摘 | Ceballos M A Prato C A | 2008 | Journal of Sound and Vibration2008，317，4： | 1 |
| 17 | Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin- 12 显示文摘 | Ceballos A Sabatte J Nahmod K | 2007 | Immunology2007，121，3： | 1 |
| 18 | Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3 '-triiodo-L-thyronine显示文摘 | Ceballos A Belinchon MM Sanchez-Mendoza E | 2009 | Endocrinology2009，150，： | 1 |
| 19 | Mean soil moisture estimating using temporal stability analysis显示文摘 | Marty'nez-Ferna ndez J Ceballos A | 2005 | Journal of hydrology2005，312，： | 1 |
| 20 | Barium selenate supplementation and its effect on in- tramammary infection in pasture-based dairy cows 显示文摘 | CEBALLOS A KRUZE J BARKEMA H W | 2010 | Journal of Dairy Science2010，93，4： | 1 |
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