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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Protective Effects of Calcium Antagonists on Cadmium-induced Toxicity in Rats显示文摘Protective effects of calcium antagonists, chlorpromazine (CPZ) and nimodepine (NI-MO), on cadmium-induced toxicity were investigated. After giving CdCl2 (0. 44mg Cd/kg,ip), CPZ (5mg/kg, ip) or NIMO (8mg/kg, po) were administered every day to Sprague-Dawley (S. D. ) rats for a week. Then, urinary N- acetyl-β-D- glucosaminidase (NAG ), uri -nary cadmium and bloocl cadmium were measured. The accumulation of cadmium in the kid-ney cortex, content of renal calmodulin, hemoglobin and the ultrastructural damage of proxi-mal convoluted tubules of rats were examined three weeks after the last administration. Re-sults indicated that the calcium antagonists partly protected against toxic effects induced bycadmium in different manners. These data provide further evidence for the new hypothesisthat the cross effect of cadmium and calcium in calmodulin regulated systems may be responsi-ble for the mechanism of cadmium intoxication. ’The results suggested that the calcium antag-onists could be a new and promising approach in the therapy of heavy metaLinduced | YANG XIANFANG YANG YONG-NIAN(Institute of Applied Toxicology, Nanjing the Medical University,Nanjing 210029, China)Abbreviation are Ca, calcium CaM, calmodulin Cd, cadmium CPZ, chlorpromazine Hb, hemogobin NIMO, nimodepine NAG, N-acetyl-β-D- gluco | 1997 | Biomedical and Environmental Sciences1997，10，4： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | V1A -4 mediated adhesion to morrow stromal cells confers chemoresistance to adherent lymphoma cells 显示文摘 | Weeks CD Kuszynski CA Sharp JG | 2001 | Leuk Lymphoma2001，40，16： | 1 |
| 5 | A typing system for neisseria gonorrhoeae based on biotinylated oligonucleotide probes to PIB gene variable regions显示文摘 | Thompson DK Deal CD Ison CA | 2000 | J Infect Dis2000，181，5： | 1 |
| 6 | Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome显示文摘 | Prodromidi EI Poulsom R Jeffery R Roufosse CA Pollard PJ Pusey CD | 2006 | Stem Cells2006，24，11： | 1 |
| 7 | Assessing levels of hospital emergency preparedness显示文摘 | Adini LCB Goldberg CA Laor CD | 2006 | Prehosp Disast Med2006，21，6： | 1 |
| 8 | Prevalence of comor- bid anxiety disorders in primary care outpatients 显示文摘 | Sherboume CD Jakson CA Mercdith IS | 1998 | Arch Faro Med1998，7，1： | 1 |
| 9 | Estrogen-induced changes in IGF-I,Myb family and MAPkinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines显示文摘 | Swartz1 CD Afshari CA Yu L | 2005 | Mol Hum Reprod2005，11，6： | 1 |
| 10 | Posterior cruciate ligament architecture: evaluation under micro- surgical dissection显示文摘 | MAKRIS CA GEORGOULIS AD PAPAGEORGIOU CD | 2000 | Arthroscopy2000，16，6： | 1 |
| 11 | Largescale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer 显示文摘 | Hough CD Sherman-Baust CA Pizer ES | 2000 | Cancer Res2000，60，22： | 1 |
| 12 | The histone deacetylase in- hibitor vorinostat (SAHA) increases the susceptibility of uninfected CD4+ T ceils to HIV by Increasing the kinetics and efficiency of postentry viral events显示文摘 | Lucera MB Tilton CA Mao H et cd | 2014 | J Virol2014，88，10： | 1 |
| 13 | Prevalence of co- morbid anxiety discover sinprimary eareout patients 显示文摘 | Sherbourne CD Jackson CA Meredith LS | 1998 | Arch Faro Med1998，7，1： | 1 |
| 14 | Depremive disorder in primary care: prevalence, functional disability, and identification显示文摘 | Williams JW Kerber CA Mulrow CD et a | 1999 | J Gen Intern Med1999，，10： | 1 |
| 15 | Large-scale serialanalysis of gene expression reveals genes differentially expressed in ovarian cancer 显示文摘 | Hough CD Sherman-Baust CA Pizer ES | 2000 | Cancer Res2000，60，： | 1 |
| 16 | Neural and local effects of hypoxia on cardiovascular responses to obstructive apnea显示文摘 | Schneider H Schaub CD Chen CA | 2000 | J Appl Physiol2000，88，： | 1 |
| 17 | Diagnostic performance of an expert system for the interpretation of myocardial perfusion SPECT studies显示文摘 | Cooke CD Folks RD Santana CA | 2001 | J Nucl Med2001，42，8： | 1 |
| 18 | Expression of metastasis-related genes in human epithelial ovarian tumors 显示文摘 | Herrera CA Xu L Bueana CD | 2002 | Int J Oncol2002，20，1： | 1 |
| 19 | Antioxidant defense responses to sleeploss and sleeprecovery显示文摘 | Everson CA Laatsch CD Hogg N | 2005 | Am J Physiol Regul Integr Comp Physiol2005，288，2： | 1 |
| 20 | Epigenetic modifications induced by RGC-32 in colon cancer显示文摘 | Vlaicu SI Tegla CA Cudrici CD | 2010 | Exp Mol Pathol2010，88，1： | 1 |
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