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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Relation between red blood cell distribution width and all - cause mortality at two years in an unse- leered population referred for coronary angiography 显示文摘 | Cavusoglu E Chopra V Gupta A | 2010 | Int J Cardiol2010，141，2： | 1 |
| 3 | Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome 显示文摘 | Cavusoglu E Marmur JD Hojiati MR | 2011 | Am J Med2011，124，： | 1 |
| 4 | Relation of base- line plasma ADMA levels to cardiovascular morbidity and mor- tality at two years in men with diabetes mellitus referred for coronary angography显示文摘 | Cavusoglu E Ruwende C Chopra V | 2010 | Atherosclerosis2010，210，1： | 1 |
| 5 | Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial in- faraction at two years in patients presenting with acute coronary syndrome显示文摘 | Cavusoglu E Ruwende C Eng C | 2007 | Am J Cardiol2007，99，10： | 1 |
| 6 | Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography显示文摘 | Cavusoglu E Chopra V Gupta A | 2009 | Int J Cardiol2009，，12： | 1 |
| 7 | Information se- curity policy compliance:An empirical study of ra- tionality-based beliefs and information security aware- ness 显示文摘 | Bulgurcu B Cavusoglu H Benbasat I | 2010 | MIS Quarterly2010，34，3： | 1 |
| 8 | Current status of rotational atherectomy 显示文摘 | Cavusoglu E Kini AS Marmur JD | 2004 | Catheter Cardiovasc Interv2004，62，4： | 1 |
| 9 | Contrast-associated nephropathy显示文摘 | Soma VR Cavusoglu E Vidhun R | 2002 | Heart Dis2002，4，6： | 1 |
| 10 | Evaluation of the genotype MTBDR assay for rapid detection of rifampin and isoni- azid resistance in mycobacterium tuberculosis isolates 显示文摘 | Cavusoglu C Turhan A Akinci P | 2006 | J Clin Microbiol2006，44，7： | 1 |
| 11 | Evaluation of C - reactive protein fibrinogen and antithrombin - 2 as risk factor for coronary artery disease显示文摘 | Cavusoglu Y Gorenek B Alpsoy S | 2001 | Isr med Assoc J2001，3，： | 1 |
| 12 | Current status of rotational athereetomy 显示文摘 | Cavusoglu E Kini AS Marmur JD | 2004 | Catheter Cardiovasc Interv2004，62，4： | 1 |
| 13 | Relation between red cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography显示文摘 | Cavusoglu E Chopra V Gupta A | 2009 | Int J Cardiol2009，12，： | 1 |
| 14 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1in patients with coronary artery disease显示文摘 | CAVUSOGLU Y TIMURALP B US T | 2004 | Angiology2004，55，： | 1 |
| 15 | The prevention of contrast-induced nephropathy in patients undergoing percutaneous coronary intervention显示文摘 | Cavusoglu E Chhabra S Marmur JD | 2004 | Minerva Cardioangiol2004，52，5： | 1 |
| 16 | Adiponectin is an independent predictor of allcause mortality,cardiac mortality,and myocardial infarction in patients presenting with chest pain显示文摘 | Cavusoglu E Ruwende C Chopra V | | 0，，： | 1 |
| 17 | Gamification: A New Paradigm for Online User Engagement显示文摘 | Kankanhalli A Taher M Cavusoglu H | 2012 | 2012，，： | 1 |
| 18 | Mycobacterium tuberculosis infection and laboratry diagnosis in solid-organ transplant recipients显示文摘 | Cavusoglu C Cicek-Saydarn C Karasu Z | 2002 | Clin Transplant2002，16，4： | 1 |
| 19 | Rela'don between red blood cell distribution width (RDW) and all-cause mortality at lwo years in an unselected population referred for coronary anglography显示文摘 | Cavusoglu E Chopra V Gupta A | 2010 | Jut J Cardiol2010，141，2： | 1 |
| 20 | Relation of baseline plasma phospholipid transfer protein (PLTP) activity to left ventricular systolic dysfunction in patients referred for coronary angiography 显示文摘 | CAVUSOGLU E MARMUR J D CHHABRA S | 2009 | Atherosclerosis2009，207，1： | 1 |
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