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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Incidence of primary and recurrent acute urinary retention between 1998 and 2003 in England显示文摘 | Cathcart P van der Meulen J Armitage J Emberton M | 2006 | J Urol2006，176，1： | 1 |
| 3 | Purification and partial amino acid sequence of plantaricin S ,a bacteriocin produced by Lactobacillus plantarum LPCO10,the activity of which depends on the complementary action of two peptides显示文摘 | Jimenez-Diaz R Ruiz-Barba J L Cathcart D P | 1995 | App1 Environ Microbiol1995，61，： | 1 |
| 4 | The Oxidation ofZircaloy-4 at 900 and 1100℃ in High Pressure Steam显示文摘 | Pawel R E Cathcart JV Cambell J J | 1979 | Journal of Nuclear Materials1979，82，： | 1 |
| 5 | Purification and partial amino acid sequence of plantaricin S,a bacteriocin produced by Lactobacillus plantarum LPCO10,the activity of which depends on the complementary action of two peptides显示文摘 | Jimenez-Diaz R Ruiz-Barba J L Cathcart D P | | 0，，12： | 1 |
| 6 | Fertilizer nitrogen rate and the response of weeds to herbicides显示文摘 | Cathcart R J Chandler K Swanton C J | 2004 | Weed Science2004，52，： | 1 |
| 7 | A multivalent bcrabl fusion peptide vaccination trial in patients with chronic myeloid leukemia显示文摘 | Cathcart K Pinilla-Ibarz J Korontsvit T | 2004 | Blood2004，103，3： | 1 |
| 8 | 显示文摘 | Pinilla-lbarz J Cathcart K Korontsvit T | 2000 | Blood2000，95，5： | 1 |
| 9 | A muhivalent bcr/abl fusion peptide vaccination trial in patients with chronic myeloid leukemia 显示文摘 | Cathcart K Pinilla-lbarz J Korontsvit T | 2004 | Blood2004，103，： | 1 |
| 10 | Degradation of 2,4-D and 2,4-D in 114 agricultural soils as affected by soil organic carbon content 显示文摘 | Gaultier J Farenhorst A Cathcart J | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
| 11 | Control of high pH in aquaculture ponds 显示文摘 | POTE J W CATHCART T P DELIMAN P N | 1990 | Aquaculture Engineering1990，9，3： | 1 |
| 12 | Span of control matters显示文摘 | Cathcart D Jeska S Karnas J | 2004 | Journal of Nursing Administration2004，34，9： | 1 |
| 13 | A multivalent bcr-abl fusinn peptide vaccination trial in patients with chronic mye-loid leukemia显示文摘 | Cathcart K Pinilla-lbarz J Korontsvit T | 2004 | Blood2004，103，3： | 1 |
| 14 | Degradation of 2, 4-D and 2, 4-D in 114 agricultural soils as affected by soil organic carbon content 显示文摘 | GAULTIER J FARENHORST A CATHCART J | 2008 | Soil Biology and Biochemistry2008，40，1： | 1 |
| 15 | Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight obese men显示文摘 | WHYTE L J GILL J M CATHCART A J | 2010 | Metabolism2010，59，10： | 1 |
| 16 | Helical CT scanning of the nose and paranasal sinuses using a low dose protocol:in comparison to conventional CT显示文摘 | Cathcart J Bailie N Gallagher G | 2002 | Radiography2002，8，1： | 1 |
| 17 | A description of radical nephrectomy practice and outcomes in England:1995-2002显示文摘 | Nuttall M Cathcart P van der Meulen J | 2005 | BJU Int2005，96，1： | 1 |
| 18 | A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia显示文摘 | Cathcart K Pinilla-Ibarz J Korontsvit T | 2004 | Blood2004，103，3： | 1 |
| 19 | Fermentation activity and survival of yeast in frozen fermented and unfermented doughs显示文摘 | Godkin W J Cathcart W H | 1949 | Food Technol1949，，3： | 1 |
| 20 | Vaccination of pationts with chronic myelogenons leukemia with ber-abl oncngane breakpoint fusion peptides generates specific immuneresponses显示文摘 | Pinilla-Ibarz J Cathcart K Korontsvit T | 2000 | Blood2000，95，5： | 1 |
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