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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 4 | Use of a fuzzy machine learning technique in the knowledge acquisition process显示文摘 | Castro J L Castro-Schez J J Zurita J M | 2001 | Fuzzy Sets and Systems2001，123，3： | 2 |
| 5 | The role of viral respiratory infections in the pathogenesis and exacerbation of asthma显示文摘 | Cohen L Castro M | 2003 | Semin Respir Infect2003，18，1： | 2 |
| 6 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 7 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 8 | Learning and optimization using the clonal selection principle 显示文摘 | Castro L N D Von Zuben F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 9 | Optimisation of shape and process parameters in metal forging using genetic algorithms显示文摘 | CASTRO C F ANTONIO C A C SOUSA L C | 2004 | Journal of Material Processing Technology2004，146，3： | 1 |
| 10 | Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells显示文摘 | Spinella F Rosanò L Di Castro V | 2004 | Clin Cancer Res2004，10，14： | 1 |
| 11 | Experimental con- strains on Hercynian anatexis in the Iberian massif, Spain 显示文摘 | Castro A Corretg L G EI-Biad M | 2000 | Journal of Petrology2000，41，： | 1 |
| 12 | Solutions of xanthan gum/gu- argum mixtures: Shear rheology, porous media flow and solids transport in annular flow 显示文摘 | Amundarain J L Castro L J | 2009 | Rheologica Acta2009，48，： | 1 |
| 13 | Mechanisms of clearance of treponema pallidum from the CSF in a nonhuman primate model 显示文摘 | Marra CM Castro CD Kuller L | 1998 | Neurology1998，51，4： | 1 |
| 14 | Determination of selenium in nutritional supplements and shampoos by flow injection-hydride generation-atomic fluorescence spectrometry 显示文摘 | Gomiz-Gracia L Luque De Castro M D | 1999 | Talanta1999，50，4： | 1 |
| 15 | Co-occurrence of aflatoxins B1, B2,G1,G2,zearalenone and fumonisin B1 in Brazilian corn显示文摘 | Vargas E A Preis R A Castro L | 2001 | Food Addit Con- tam2001，18，11： | 1 |
| 16 | Business and so- cial reputation: Exploring the concept and main Dimen- sions of corporate reputation 显示文摘 | De Castro G M Lopez J E N Sdez P L | 2006 | Journal of Business Ethics2006，63，4： | 1 |
| 17 | Operational experience with the 450 kV injector for the superconducting cyclotron显示文摘 | CIAVOLA G CASTRO M CELONA L | 1996 | Nucl Instrum Methods1996，382，： | 1 |
| 18 | Expression of connexins 36,43, and 45 during postnatal development of the mouse retina显示文摘 | Kiahara AH Mantovani de Castro L Belmonte MA Yan CY Moriscot AS Hamassald DE | 2006 | J Neurobiol2006，66，13： | 1 |
| 19 | The Construction of a Boolean Competitive Neural Network Using Ideas from Immunology显示文摘 | Von Zuben F J De Deus J G A | 2003 | Neurocomputing2003，50，： | 1 |
| 20 | Gemini surfactants from alkyl glueosides显示文摘 | Castro Mariano J L Kovensky José Cirelli Alicia Fernéndez | 1997 | Tetrahedron Letters1997，38，23： | 1 |
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