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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 3 | Different cytokine levels in thrombolysis patients as predictors for clinical outcome显示文摘 | Mazzotta G Sarchielli P Caso V | 2004 | Eur J Neurol2004，11，： | 1 |
| 4 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echoeardiography in patients with idiopathic dilated cardiomyopathy and 'narrow' QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 5 | The role of carotid ar- tery stenting and carotid endarterectomy in cognitive per- formance a systematic review显示文摘 | De Rango P Caso V Leys D | 2008 | Stroke2008，39，11： | 1 |
| 6 | Analysis of right ventricular Doppler tissue imaging and load dependence in patients undergoing percutaneous closure of atrial septal defect显示文摘 | PASCOTTO M CASO P SANTORO G | 2004 | Am J Cardiol2004，94，9： | 1 |
| 7 | Association hetween left ventricular structure and cardiac performance during effort in two morphological forms of athlete's heart显示文摘 | D'Andrea A Limongelli G Caso P | | 0，，： | 1 |
| 8 | Stress-induced ox idalive changes in brain显示文摘 | Madrigal JL Garcia-Bueno P Caso JR | 2006 | CNS Neurol Disord Drug Targets2006，5，5： | 1 |
| 9 | Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: a two-di- mensional speckle strain study 显示文摘 | D' Andrea A Caso P Romano S | 2009 | Int J Cardiol2009，132，3： | 1 |
| 10 | Association between lett atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy:a two-dimensionals peckle strain study显示文摘 | Dp Andrea A Caso P Romano S | 2009 | Int J Cardiol2009，132，3： | 1 |
| 11 | Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins显示文摘 | Caso G Kelly P McNurlan MA | 2007 | Am J Cardiol2007，99，10： | 1 |
| 12 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and'narrow'QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 13 | Right ventricular myocardial dysfunction in adult patients late after repair of tetralogy of fallot显示文摘 | D'Andrea A Caso P Sarubbi B | 2004 | Int J Cardiol2004，94，： | 1 |
| 14 | Involvement of IL-1 beta in acute stress-induced worsening of cerebral ischaemia in rats显示文摘 | Caso JR Moro MA Lorenzo P | 2007 | Eur Neuropsychopharmacol2007，17，9： | 1 |
| 15 | Association between left atri- al myocardial function and exercise capacity in patients with either idiopathicor ischemic dilated cardiomyopathy: a two-dimensional speckle strain study 显示文摘 | D'Andrea A Caso P Romano S | 2009 | Int J Cardio12009，132，3： | 1 |
| 16 | The role of tumor necrosis factor-alpha in stress-induced worsening of cerebral ischemia in rats显示文摘 | Caso JR Lizasoain I Lorenzo P | 2006 | Neuroscience2006，142，1： | 1 |
| 17 | Association between myocardial right ventricular relaxation time and pulmonary arterial pressure in chronic obstructive lung disease: analysis by pulsed Doppler tissue imaging显示文摘 | Caso P Galderisi M Cicala S | 2001 | J Am Soc Echocardiogr2001，14，10： | 1 |
| 18 | Usefulness of Doppler tissue imaging for the assessment of righe and left ventriclar myocardiacl function in patients with dual-chamber pacing显示文摘 | D' Andrrea A Duccschi V Caso P | 2001 | Int J Cardiol2001，81，1： | 1 |
| 19 | Involvement of IL-1beta in acute stress-induced worsening of cerebral ischaemia in rats显示文摘 | Caso JR Moro MA Lorenzo P | 2007 | Eur Neuropsychopharmacol2007，17，： | 1 |
| 20 | Different effects of cardiac re- synchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study显示文摘 | D'Andrea A Caso P Romano S | 2007 | Eur Heart J2007，28，22： | 1 |
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