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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells显示文摘Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system. | Benita L McVicker Dean J Tuma Carol A Casey | 2007 | World Journal of Gastroenterology2007，13，37： | 2 |
| 3 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 4 | Developmental cognitive neuroscience: progress and potential显示文摘 | MUNAKATA Y CASEY B J DIAMOND A | 2004 | Trends in Cognitive Science2004，8，3： | 1 |
| 5 | Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning显示文摘 | HARRIS K S CASEY J L COLEY A M | 2009 | J Biol Chem2009，284，14： | 1 |
| 6 | Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography显示文摘 | Casey J L Keep P A Chester K A etal | 1995 | J Immun Method1995，179，： | 1 |
| 7 | Preliminary clinical experience with the Bryan Cervical Disc Prosthesis 显示文摘 | Coffin J Casey A Kehr P | 2002 | Neurosurgery2002，51，3： | 1 |
| 8 | Distribution of living polycystine radiolarians in the Gulf of Mexico and Caribbean Sea,and comparison with the sedimentary record显示文摘 | MCMILLEN K J CASEY R E | | 0，，： | 1 |
| 9 | Effective tumor treatment using optimized ultrasound-mediated delivery of bleomycin 显示文摘 | Larkin J O Casey G D Tangney M et ol | 2008 | Ultrasound Med Biol2008，34，3： | 1 |
| 10 | The continueing value of the Apgar score for the assessment of newborn infaints显示文摘 | Casey B M Mclntire D D Leveno K J | 2001 | N Engl Med2001，334，7： | 1 |
| 11 | Cognitive changes at high altitude in healthy climbers and in climbers developing acute mountain sickness显示文摘 | M Landis T Casey J | 1991 | Aviat Space Environ Med1991，62，4： | 1 |
| 12 | Impact of critical social empowermnent on psychological and job satisfaction in nrusing and midwifery settings显示文摘 | Casey M Saunders J O' Hara T | 2010 | J Nurs Manag2010，18，1： | 1 |
| 13 | Clinical significance of betero- topic ossification in cervical disc replacement: a prospective mul- ticenter clinical trial显示文摘 | Leung C Casey AT Coffin J | 2005 | Neurosurgery2005，57，4： | 1 |
| 14 | Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era 显示文摘 | Pichichero M E Casey J R | 2007 | Pediatric In- fectious Disease Journal2007，，10： | 1 |
| 15 | Ipsilateral concomitant fractures of the hip and femoral shaft显示文摘 | Casey M J Chapnman M W | 1979 | J Bone Joint Surg (Am)1979，61，4： | 1 |
| 16 | Weekly compared with daily blood glucose monitoring in women with diet-treated gestational diabetes显示文摘 | HAWKINSJ S CASEY B M LO J Y | 2009 | Obstet Gynecol2009，113，6： | 1 |
| 17 | Preliminary clinical experience with the Bryan Cervical Disc Prosthesis 显示文摘 | Goffin J Casey A Kehr P | 2002 | Neuroseurgery2002，51，3： | 1 |
| 18 | Fluoride tolerance of laying hens显示文摘 | COETZEE C B CASEY N H MEYER J A | 1997 | Br Poult Sci1997，38，5： | 1 |
| 19 | Bright-blood T2-weighted MRI has higher diagnostic accuracy than dark-blood short tau inversion recovery MRI for detection of acute myocardial infarction and for assessment of the ischemic area at risk and myocardial salvage显示文摘 | Payne AR Casey M McClure J | 2011 | Circ Cardiovasc Imaging2011，4，： | 1 |
| 20 | Isotopic fractiuna- tion of Mg2+ (aq), Ca2+ (aq), and Fe2+ (aq) with carbonate minerals显示文摘 | Rustad J R Casey W H Yin Q | 2010 | Geochimica et Cosmochimica Acta2010，74，： | 1 |
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