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| 1 | Physical activity support or weight loss counseling for nonalcoholic fatty liver disease?显示文摘AIM:To determine the clinical effectiveness of intense psychological support to physical activity(PA)in nonalcoholic fatty liver disease(NAFLD),compared with cognitive-behavioral treatment(CBT).METHODS:Twenty-two NAFLD cases received support to exercise,tailored to their motivational needs(PA group).The effects on body weight,physical fitness[6-min walk test,VO2max and the PA-rating(PA-R)questionnaire]and body fat(fatty liver indices and visceral adiposity index)were compared with data obtained in 44 NAFLD subjects enrolled in a CBT program for weight loss,after adjustment for propensity score,calculated on baseline data.Measurements were performed at baseline,at 4-mo and one-year follow-up.Changes in anthropometric,biochemical and PA parameters were tested by repeated measurement ANOVA.Outcome results were tested by logistic regression analysis.RESULTS:At the end of the intensive program,BMI was less significantly reduced in the PA group(-1.09±1.68 kg/m2 vs-2.04±1.42 kg/m2 in the CBT group,P=0.019)and the difference was maintained at 1-year follow-up(-0.73±1.63 vs-1.95±1.88,P=0.012)(ANOVA,P=0.005).PA-R was similar at baseline,when only 14%of cases in PA and 36%in CBT(P=0.120)recorded values≥3.At 4 mo,a PA-R≥3 was registered in 91%of PA and 46%of CBT,respectively(P<0.001)and PA-R≥5(up to 3 h/wk of moderate-toheavy intensity physical activity)was registered in 41%of PA and only 9%of CBT group(P<0.007).The6-min walk test increased by 139±26 m in PA and by only 43±38 m in CBT(P<0.001)and VO2max by8.2±3.8 mL/kg per minute and 3.3±2.7 mL/kg per minute,respectively(P<0.002).After adjustment for propensity,weight loss>7%was significantly associated with CBT group at one year(OR=6.21;95%CI:1.23-31.30),whereas PA-R>3 was associated with PA group(10.31;2.02-52.63).Liver enzymes decreased to values within normal limits in 36%of PA cases and61%of CBT(P<0.070).Estimated liver fat(Kotronen index)fell below the fatty liver threshold in 36%of PA and 34%and CBT cases at one-year(not different).Also the fatty liver index and the visceral adiposity index improved to a similar extent.CONCLUSION:Intensive psychological counseling for PA produces hepatic effects not different from standard CBT,improving physical fitness and liver fat independent of weight loss.Strategies promoting exercise are worth and effective in motivated patients,particularly in lean NAFLD patients where large weight loss cannot be systematically pursued. | Luca Montesi Chiara Caselli Elena Centis Chiara Nuccitelli Simona Moscatiello Alessandro Suppini Giulio Marchesini | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 2 | Actual concept of 'probiotics':Is it more functional to science or business?显示文摘It is our contention that the concept of a probiotic as a living bacterium providing unspecified health benefits is inhibiting the development and establishment of an evidence base for the growing field of pharmacobiotics.We believe this is due in part to the current regulatory framework,lack of a clear definition of a probiotic,the ease with which currently defined probiotics can be positioned in the market place,and the enormous profits earned for minimum investment in research.To avoid this,we believe the following two actions are mandatory:international guidelines by a forum of stakeholders made available to scientists and clinicians,patient organizations,and governments;public research funds made available to the scientific community for performing independent rigorous studies both at the preclinical and clinical levels. | Michele Caselli Francesca Cassol Girolamo Calò John Holton Giovanni Zuliani Antonio Gasbarrini | 2013 | World Journal of Gastroenterology2013，19，10： | 3 |
| 3 | Chapter 9 Accounting for Cross-Country Income Differences显示文摘 | Francesco Caselli | 2005 | Handbook of Economic Growth2005，，： | 2 |
| 4 | Interactions between triazoles andamphotericin B against cryprococcus neoformans显示文摘 | Barchiesi F Schimizzi AM Caselli F | 2000 | Antimierob Agents Chemother2000，44，9： | 1 |
| 5 | Local and systemic inoculation of DNA or protein gpB1s-based vaccines induce a protective immunity against rabbit ocular HSV-1 infection显示文摘 | Balboni PG Incorvaia C | 2001 | Vaccine2001，19，： | 1 |
| 6 | Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOEε4 allele显示文摘 | Reiman EM Osbome D | 2004 | Neurology2004，62，： | 1 |
| 7 | Left ventricular remodelling index (LVRI) in various pathophysiological conditions: a real-time three-dimensional echocardiographic study 显示文摘 | De Castro S Caselli S Maron M | 2007 | Heart2007，93，2： | 1 |
| 8 | Chemo-enzymatie synthesis of levodropropizine显示文摘 | Caselli E Tosi G Forni A | 2003 | Ⅱ Farmaco2003，58，： | 1 |
| 9 | Transcutaneous oxygen tension monitoring after successful revascularization in diabetic patients with ischaemic foot ulcers显示文摘 | Caselli A Latini V Lapenna A | 2005 | Diabet Med2005，22，4： | 1 |
| 10 | Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects显示文摘 | M. Cabiati L. Sabatino R. Caruso C. Caselli T. Prescimone D. Giannessi S. Del Ry | 2012 | Peptides2012，，2： | 1 |
| 11 | Synthesis and biological activity of some transition-state inhibitors of human renin显示文摘 | Buhlmayer P Caselli A Fuhrer W | 1988 | J Med Chem1988，31，9： | 1 |
| 12 | Multitechnique Approach to V-Zr Si O4Pigment Characterization and Synthesis Optimization显示文摘 | Caselli C Lusvardi G Malavasi G | 2007 | Journal of European Ceramic Society2007，27，： | 1 |
| 13 | Obstructive sleep apnea,apolipoprotein,and mild cognitive impairment显示文摘 | Richard J Caselli MD | 2008 | Sleep Med2008，9，8： | 1 |
| 14 | Interactions of posaconazole and flucytosine against Cryptococcus neoformans 显示文摘 | Barchiesi F Schimizzi AM Najvar LK Bocanegra R Caselli F Cesare SD | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
| 15 | Biochemical and ultrastructural study of actidione-cycloheximide effect on fat intestinal absorption in the rat (author's transl) 显示文摘 | Bernard A Carlier H Caselli C | 1980 | J Physiol (Paris)1980，76，14： | 1 |
| 16 | Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7 显示文摘 | Caselli E Di Luca D | 2007 | New Microbiol2007，30，3： | 1 |
| 17 | Chronic obstructive pulmonary disease is associated with altered neuropsychological performance in young adults显示文摘 | De Carolis A Giubilei F Caselli G | 2011 | Dement Geriatr Cogn Dis Extra2011，1，1： | 1 |
| 18 | Obstructive sleep apnea,apolipoprotein and mild cognitive impairment 显示文摘 | Richard J Caselli M D | 2008 | Sleep Med2008，9，8： | 1 |
| 19 | High peripheral levels of h-FABP are associated with poor prognosis in end-stage heart failure patients with mechanical circulatory sup- port显示文摘 | CABIATI M CASELLI C CARUSO R | 2013 | Biomark Med2013，7，3： | 1 |
| 20 | Sterold-responsive encephalopathy associated with autoimmune thyroiditis 显示文摘 | Castillo P Woodruff B Caselli R | 2006 | Arch Neurol2006，63，： | 1 |
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