|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation. | Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 2 | Time - series minimum - wage studies : A meta - analysis 显示文摘 | Card D A B Krueger | 1996 | American Economic Review1996，85，： | 1 |
| 3 | Effects of market and regulatory changes on livestock manure management in southern Alberta显示文摘 | SMITH E G CARD G YOUNG D L | 2006 | Canadian Journal of Agricultural Conomics2006，54，2： | 1 |
| 4 | Do Minimum Wages Reduce Employment?A Case Study of California,1987-1989显示文摘 | Card D | 1992 | Industrial and Labor Relations Review1992，46，1： | 1 |
| 5 | Oct4/Sox2 -regulated miR -302 targets Cyclin D1 in human ESC显示文摘 | D AGreer Card P B Hebbar L Li | 2008 | Mol Cell Biol2008，28，20： | 1 |
| 6 | Pulmonary applications and toxicity of engineered nanopartieles显示文摘 | Card J W Zeldin D C Bonner J C | 2008 | J Physiol Lung Cell Mol Physiol2008，295，2： | 1 |
| 7 | Oct4/Sox2-regulated miR-302 targets cyclin Dl in human embryonic stem ceils显示文摘 | Card D A Hebbar P B Li L | 2008 | Mol Cell Biol2008，28，20： | 1 |
| 8 | Bioactive recombinant human lactoferrin, derived from rice, stimulates mammalian cell growth 显示文摘 | Huang N Bethell D Card C | 2008 | In Vitro Cell Dev Biol Anim2008，44，10： | 1 |
| 9 | Effect of market and regulatory changes on livestock manure management in Southern Alberta 显示文摘 | Smith E Card G Young D L | 2006 | Canadian Journal of Agriculture Economic2006，54，2： | 1 |
| 10 | Direct thickners for mobility control of CO2 floods 显示文摘 | HELLER J P DANDGE D K CARD R J | 1985 | SPE Journal1985，25，5： | 1 |
| 11 | School quality and black-white relative earnings: A direct assessment显示文摘 | Card D Krueger A B | 1992 | The Quarterly Journal of Economics1992，107，1： | 1 |
| 12 | Does school quality matter? returns to education and the characteristics of public schools in the United States显示文摘 | CARD D KRUEGER A | 1992 | Journal of Political Economy1992，，1： | 1 |
| 13 | Skill-biased Technological Change and Rising Wage Inequality: Some Problems and Puzzles 显示文摘 | CARD D DINAIDO J E | 2002 | Journal of Labor Economics2002，20，4： | 1 |
| 14 | Estimating the Return to Schooling: Progress on Some Persistent Econometric Problems显示文摘 | Card D | 2001 | Econo- metrica2001，69，5： | 1 |
| 15 | Using the longitudinal structure of earnings to estimate the effect of training programs 显示文摘 | Ashenfelter O Card D | 1985 | Rev EconStat1985，67，4： | 1 |
| 16 | Ultrosonic Velocity of Sound and Void Fraction in a Bubbly Mixture显示文摘 | Card D C Sims G E Chant R E | 1971 | J Basic Eng1971，93，12： | 1 |
| 17 | Soil pH显示文摘 | Whiting D Card A Wilson C et d | 2011 | Colorado State University Extension2011，222，： | 1 |
| 18 | Unions and Wage Inequality 显示文摘 | Card D Lemieux T Riddell W C | 2004 | Journal of Labor Research2004，25，4： | 1 |
| 19 | Minimum Wages and Employment:A Case Study ofthe Fast-Food Industry in New Jerseyand Pennsylvania:Reply显示文摘 | Card D KruegerA | 2000 | American Economic Review2000，90，5： | 1 |
| 20 | An information approach to examining developments in energy technology : coal gasification 显示文摘 | Frame D J Baum J J Card M | 1979 | Journal of the American Society for Information Science1979，30，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员