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| 1 | Assessing impacts of different land use scenarios on water budget of Fuhe River,China using SWAT model显示文摘The Soil and Water Assessment Tool(SWAT)model was used to assess the impacts of different land use scenarios on hydrological processes in the Fuhe watershed in Poyang Lake Basin,East China.A total of 12 model parameters were calibrated with observed monthly runoff data for 1982-1988 and validated for 1991-1998 for baseline conditions.The baseline test results of R2 and Nash-Sutcliffe model efficiency(NSE)values ranged between 0.88 and 0.94 across the calibration and validation periods,indicating that SWAT accurately replicated the Fuhe watershed streamflow.Several different land use scenarios were then simulated with the model,focusing on the impacts of land use change on the hydrology of the watershed.The results of hypothetical scenario simulations revealed that surface runoff declined while groundwater recharge and evapotranspiration(ET)increased,as forest land,agriculture land and/or grassland areas increased,as well as when paddy field and urban areas decreased.These results further showed that forest land has a higher capacity to conserve the water as compared to pasture land.The results of the real scenario simulations revealed that urbanization is the strongest contributor to changes in surface runoff,water yield,and ET.Urbanization can be considered as a potential major environmental stressor controlling hydrological components. | Tao Can Chen Xiaoling Lu Jianzhong Philip W.Gassman Sauvage Sabine Sanchez Pérez José-Miguel | 2015 | International Journal of Agricultural and Biological Engineering2015，8，3： | 4 |
| 2 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 3 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 4 | Rigid Thermosetting Liquid Molding Resins from Renewable Resources显示文摘 | CAN E WOOL S R P | 2002 | Journal of Applied Polymer Science2002，83，5： | 1 |
| 5 | Mistakes in a stat laboratory: types and fre- quency 显示文摘 | Plebani M Can'am P | 1997 | Clin Chem1997，43，81： | 1 |
| 6 | Peroxidase and poly- phenol oxidase in longterm frozen stored papaya slices dif- fereces among hermaphrodite and female papaya fruits 显示文摘 | Can M P Lobo M G Ancoso B D | 1998 | J Sci Food Agri1998，，76： | 1 |
| 7 | A novel farnesyl-protein transferase inhibitor produced by Chrysosporium lobatum显示文摘 | Cans P Debernard J J | 1995 | Journal of Antibiotics1995，48，7： | 1 |
| 8 | Pulmonary-vein stenosis embolism after radiofrequency ablation for atrial fibrillation显示文摘 | Wang W Zhou J P Wu L Q can mimic massive pulmonary | 2011 | Respir Care2011，56，6： | 1 |
| 9 | Active disease requiring TNF-alpha-antagonist therapy can be well discriminated with different ASDAS sets:a prospective,follow-up of disease activity assessment in ankylosing spondylitis显示文摘 | Aydin SZ Can M Atagunduz P | 2010 | Clin Exp Rheumatol2010，28，5： | 1 |
| 10 | Winter runoff losses of phosphorus from paddy soils in the Taihu Lake Region of South China 显示文摘 | Zhang H C Can Z H Wang G P | 2003 | Chemosphere2003，52，： | 1 |
| 11 | Novel L Adaptive Control Methodology for Aerial Refueling with Guaranteed Transient Performance 显示文摘 | Wang Jiang Vijay P Can Chengyu | 2008 | Journal of Guidance Control and Dynamics (S0731-5090)2008，31，1： | 1 |
| 12 | Intervertebral disc tissue engineering Ⅱ:cultures of nucleus pulposus cells显示文摘 | Can JC Ducheyne P Vresilovic EJ | 2008 | Clin Orthp Relst Res2008，411，： | 1 |
| 13 | Pulsed magnetic fields improve osteoblast activity during the repair of an experimental osseous defect 显示文摘 | Cans V Botti P Soana S | 1993 | J Orthop Res1993，11，5： | 1 |
| 14 | Intervertebral disc tissue enginee- ring II : cultures of nucleus pulposus celia 显示文摘 | Can JC Ducheyne P Vresilovic EJ | 2003 | Clin Orthop2003，，411： | 1 |
| 15 | Recombinant soybean protein β-conglycinin α'subunit expression and induced hypersensitivity reaction in rats 显示文摘 | Guo P Piao X Can Y | 2008 | International Archives of Allergy and Immunology2008，145，： | 1 |
| 16 | Loss of Function of OsDCL1 Affects MicroRNA Accumulation and Causes Developmental Defects in Rice显示文摘 | Liu B Li P Can X | 2005 | Plant Physiology2005，139，1： | 1 |
| 17 | Amperometric Nitrate Biosensor Based on Carbon Nanotube/Polypyrrole/Nitrate Reductase Biofilm E- lectrode显示文摘 | Can F Ozoner S K Ergenekon P | 2012 | Materials Science and Engineering C2012，32，1： | 1 |
| 18 | Adverse effects of antiretroviraltherapy显示文摘 | Can A Cooper P A | 2000 | Lancet2000，356，9239： | 1 |
| 19 | Traffic analysis and video quality evaluation of multiple description coded video services for fourth generation wireless IP networks显示文摘 | Fitzek F H P Can B Prasad R | 2005 | Int J Wireless Personal Commun2005，35，12： | 1 |
| 20 | The clinical use of enriched bone mar- row stem cells combined with porous beta -tricalcium phosphate in posterior spinal fusion 显示文摘 | Can Y Dai K Zhang P | 2008 | Biomaterials2008，29，39： | 1 |
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