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101篇 您的检索式：作者名="CAMUS G"

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	题名	作者	年代	出处	被引量
1	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.	Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol	2016	World Journal of Hepatology2016，8，21：	5
2	The effect of order on hydrogen embrittlement of Ni3Fe显示文摘	CAMUS G M STOLOFF N S DUQUETTE D T	1989	Acta Metall1989，37，5：	1
3	Analysis of the risk factors with regard to the occurrence of ectopic pregnancy after medically assisted procreation显示文摘	Verhulst G Camus M Bollen N	1993	Hum Reprod1993，8，：	1
4	Bio-marker responses in polar cod(Boreogadus saida)exposedto the water soluble fraction of crude oil显示文摘	Jasmine Nahrgang Lionel Camus Mark G Carls	2010	Aquatic Toxi-cology2010，97，3：	1
5	Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting:an analysis of integrated data 显示文摘	SCHUG S A JOSHI G P CAMU F	2009	Anesth Analg2009，108，1：	1
6	Hysteroscopic septum re- section in patients with recurrent abortions or infertility显示文摘	Grimbizis G Camus M Clasen K	1998	Human Reprod1998，13，5：	1
7	Biomarker responses in polar cod (Boreogadus saida ) exposed to the water soluble fraction of crude oil 显示文摘	Jasmine Nahrgang Lionel Camus Mark G Carls	2010	Aquatic Toxicology2010，97，：	1
8	Modelling of the mechanical behavior and damage processes of fibrous ceramic matrix composites:Application to a 2-D SiC/SiC显示文摘	Camus G		0，，06：	1
9	Piroxicam fails to reduce myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise显示文摘	Croisier J L Camus G Monfils T	1996	Mediators Inflamm1996，5，3：	1
10	Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions显示文摘	Lopez-Vergès S Camus G Blot G Beauvoir R Benarous R Berlioz-Torrent C	2006	Proc Natl Acad Sci USA2006，103，14：	1
11	A constitutive model for the mechanical behavior of a 3D C/C composite显示文摘	Pailhes J Camus G Lamon J		0，，03：	1
12	Oxidation effects on the mechanical properties of 2D woven C/ SiC composites显示文摘	Larnouroux F Camus G	1994	Journal of the European Ceramic Society1994，14，2：	1
13	Effects of hydrogen cyanamide plus mineral oil sprays in vitis vinifera 显示文摘	Reginato M G Pinilla D C Camus C J L	1994	Agriculture Technology (Chile)1994，54，2：	1
14	Oxidation effects on the mechanical properties of 2D woven C/SiC composites 显示文摘	LAMOUROUX F CAMUS G	1994	Journal of the European Ceramic Society1994，14，2：	1
15	Modeling of the mechanical behavior and damage processes of fibrous ceramic matrix composites:application to a 2-D SiC/SiC显示文摘	CAMUS G	2000	International Journal of Solids and Structures2000，37，：	1
16	Modeling of the mechanical behavior and damage processes of fibrous ceramic matrix composites : application to a 2-D SiC/SiC显示文摘	Camus G	2000	International Journal of Solids and Structures2000，37，：	1
17	Development of damage in a 2D woven C/SiC composite under mechanical loading I mechanical eharaeterization显示文摘	CAMUS G GUILLAUMAT L BASTE S	1996	Composite Science and Technology1996，56，：	1
18	Kinetics and mechanisms of oxidation of 2D woven C/SiC composites: 1-experimental approeh显示文摘	Lamouroux F Camus G Naslain R	1994	J Am Ceram Soe1994，77，8：	1
19	Kinetics and mechanisms of oxidation of 2D woven C/SiC composites: 2-theoretical approch显示文摘	Lamouroux F Camus G Naslain R	1994	J Am Ceram Soc1994，77，8：	1
20	Oxidation effects on the mechanical properties of 2D woven C/SiC composites 显示文摘	Lamourou F Camus G	1994	J Euro Ceram Soc1994，14，2：	1

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