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71篇 您的检索式:作者名="CAMPELLO J"
    题名 作者 年代 出处 被引量
1Repurposing metformin for the treatment of gastrointestinal cancer显示文摘Diabetes mellitus type 2 and cancer share many risk factors.The pleiotropic insulin-dependent and insulin-independent effects of metformin might inhibit pathways that are frequently amplified in neoplastic tissue.Particularly,modulation of inflammation,metabolism,and cell cycle arrest are potential therapeutic cancer targets utilized by metformin to boost the anti-cancer effects of chemotherapy.Studies in vitro and in vivo models have demonstrated the potential of metformin as a chemo-and radiosensitizer,besides its chemopreventive and direct therapeutic activity in digestive system(DS)tumors.Hence,these aspects have been considered in many cancer clinical trials.Case-control and cohort studies and associated meta-analyses have evaluated DS cancer risk and metformin usage,especially in colorectal cancer,pancreatic cancer,and hepatocellular carcinoma.Most clinical studies have demonstrated the protective role of metformin in the risk for DS cancers and survival rates.On the other hand,the ability of metformin to enhance the actions of chemotherapy for gastric and biliary cancers is yet to be investigated.This article reviews the current findings on the anti-cancer mechanisms of metformin and its apparatus from pre-clinical and ongoing studies in DS malignancies.Ademar Dantas Cunha Júnior Arinilda Campos Bragagnoli Felipe Osório Costa JoséBarreto Campello Carvalheira 2021World Journal of Gastroenterology2021,27,17:5
2Hierarchical fuzzy relational models: Linguistic interpretationand Universal approximation显示文摘Ricardo J Campello G B Wagner C 2006IEEE Trans on Fuzzy Systems2006,14,3:1
3Cluster ensemble selec- tion based on relative validity indexes显示文摘Naldi M C Carvalho A Campello R J G B 2013Data Mining and Knowl- edge Discovery2013,27,2:1
4Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage显示文摘 Rodriguez Campello A 2005J Neurol2005,252,4:1
5^13C NMR spectral analysis of lignans from Araucaria angustifolia 显示文摘Fonseca S F Campello J D P Barata L E S 1978Phytochemstry1978,17,3:1
6The real effects of financial constraints : evidence from a financial crisis 显示文摘Campello M Graham J R Harvey C R 2000Journal of Financial Economics2000,97,3:1
7Previous antiplatelet therapy is an indepondent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage显示文摘Roquer J Rodriguez Campello A Gomis M 2005J Neurol2005,252,:1
8Extended bit-filling and LDPC code design显示文摘CAMPELLO J MODHA D S 2001IEEE Global Telecommunications Conference2001,2,1:1
9Cluster ensemble selection based on relative validity indexes显示文摘NALDI M C CARVALHO A C P L F CAMPELLO R J G B 2013Data MinKnowl Disc2013,27,:1
10Sex differences in first-ever acute stroke 显示文摘Boquer J Campello AB Gomis M 2003Stroke2003,34,7:1
11The real effects of financial constraints : Evidence from a financial crisis 显示文摘Campello M Graham J R Harvey C R 2010Jour- nal of Financial Economics2010,97,:1
12Evolving clusters in gene-expression data 显示文摘HRUSCHKA E R CAMPELLO R J G B DE CAS- TRO L N 2006Information Sciences2006,176,13:1
13A sur- vey of evolutionary algorithms for clustering显示文摘HRUSCHKA E CAMPELLO R J G B FREITAS A A 2009IEEE Transactions on Systems Man and Cybernetics-Part C: Applications and Reviews2009,39,2:1
14A fuzzy extension of the Rand index and other related indexes for clustering and classification assessment显示文摘Campello R J G B 2007Pattern Recognition Letters2007,28,7:1
15Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage显示文摘Roquer J Rodriguez Campello A Gomis M 2005J Neurel2005,252,4:1
16Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage 显示文摘ROQUER J RODRIGUEZ CAMPELLO A GOMIS M 2005J Neurol2005,252,4:1
17Generalized external indexes for comparing data partitions with overlapping categories显示文摘Campello R J G B 2010Pattern Recognition Letters2010,31,9:1
18A survey of evolutionary algorithms for clustering显示文摘Hruschka E R Campello R J Freitas A A 2009IEEE Transactions on Systems Man and Cybernetics Part C:Applications and Reviews2009,39,2:1
19The real effects of financial constraints : evidence from a financial crisis 显示文摘Campello M Graham J R Harvey C R 2010Journal of Financial Economics2010,97,3:1
20Do stock prices influence corporate decisions? Evidence from the technology bubble显示文摘Campello M Graham J R 2013Journal of Financial Economics2013,107,1:1
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