|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Ifection by Mycoplasma pne umoniae and its importance as anetiological agent in childhood community-acquired pneumonias 显示文摘 | Vervloet LA Marguet C Camargos PA | 2007 | Braz Infect Dis2007，11，5： | 1 |
| 4 | Infection by Mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias 显示文摘 | Vervloet LA Marguet C Camargos PA | 2007 | Braz J Infect Dis2007，11，： | 1 |
| 5 | The role of angiotensin AT1 receptors in the diuretic, natriuretie, kaliuretic and blood pressure responses induced by angiotensin II activation of the median preoptic nucleus in conscious rats 显示文摘 | Ferreira-do-Vale C Renzi A Camargo G P | 1995 | Braz J Med Biol Res1995，28，10： | 1 |
| 6 | Infection by Mycoplasmapneumoniae and its importance as an etiological agent in child-hood community-acquired pneumonias显示文摘 | Vervloet LA Marguet C Camargos PA | 2007 | Braz J Infect Dis2007，11，5： | 1 |
| 7 | Mucocele of the gland of Blandin-Nuhn: Histological and clinical findings显示文摘 | De Camargo Moraes P Bonecker M Furuse C | 2009 | Clin Oral Investig2009，13，3： | 1 |
| 8 | Acid rain and nitrogen deposition in a sub-tropical watershed (Piracicaba): ecosystem consequences显示文摘 | Krusche A V de Camargo P B Cerri C E | 2003 | Environmental Pollution2003，121，3： | 1 |
| 9 | Optical and mechanical properties of DLC-Si coatings on polycarbonate 显示文摘 | Damasceno J C Camargo Jr S S Emona M C | 2003 | Thin SolidFilms2003，433，： | 1 |
| 10 | Infection by Mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias 显示文摘 | Vervloet LA Marguet C Camargos PA | 2007 | Braz J Infect Dis2007，11，5： | 1 |
| 11 | Infection by mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias显示文摘 | Vervloet LA Marguet C Camargos PA | | 0，，05： | 1 |
| 12 | Infection by Mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias显示文摘 | Vervloet LA Marguet C Camargos PA | 2007 | Braz J Infect Dis2007，11，5： | 1 |
| 13 | Comparison of RFLP and RAPD markers toestimate genetic relationships within and among cruciferous species显示文摘 | Thormann C E Ferrieria M E Camargo L E | 1994 | Theor Appl Genet1994，88，： | 1 |
| 14 | The N terminal pro-BNP investiation of dyspnea in the emerency department (PRIDE) study显示文摘 | JANUZZI J L J R CAMARGO C A ANWARUDDIN S | 2005 | Am J Cardiol2005，95，8： | 1 |
| 15 | Effects of the Use of Theoretical Versus Theoretical-practical Training on CPR显示文摘 | Miotto H C Camargos F R Ribeiro C V | 2010 | Arq Bras Cardiol2010，95，3： | 1 |
| 16 | Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity,dental plaque pH, and caries index in children aged 7-9 years显示文摘 | Peres R C R Camargo G Mofatto L S | 2010 | The Pharmacog J2010，10，2： | 1 |
| 17 | Comparative bioremediation of soils contaminated with diesel oil by natural attenuation,biostimulation and bioaugmentation显示文摘 | Bento F M Camargo F A Okeke B C | 2005 | Bioresource technology2005，96，： | 1 |
| 18 | Polycyclic aromatic hydrocarbons in Brazilian vegetables and fruits显示文摘 | Rojo Camargo M C Toledo M C F | 2003 | Food Control2003，14，1： | 1 |
| 19 | Infection by Mycoplasmapneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias显示文摘 | Vervloet LA Marguet C Camargos PA | | 0，，05： | 1 |
| 20 | The Problem of Helicobacter pylori Resistance to Antibiotics:A Systematic Review in Latin America显示文摘 | CAMARGO M C GARCA A RIQUELME A | 2014 | Am J Gastroenterol2014，109，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员