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| 1 | The importance of avoiding unnecessary right ventricular pacing in clinical practice显示文摘Symptomatic bradycardia is effectively treated with the implantation of a cardiac pacemaker. Although a highly successful therapy, during recent years there has been a focus on the negative effects associated with longterm pacing of the apex of the right ventricle(RV). It has been shown in both experimental and clinical studies that RV pacing leads to ventricular dyssynchrony, similar to that of left bundle branch block, with subsequent detrimental effects on cardiac structure and function, and in some cases adverse clinical outcomes such as atrial fibrillation, heart failure and death. There is substantial evidence that patients with reduced left ventricular function(LVEF) are at particular high risk of suffering the detrimental clinical effects of long-term RV pacing. The evidence is, however, incomplete, coming largely from subanalyses of pacemaker and implantable cardiac defibrillator studies. In this group of patients with reduced LVEF and an expected high amount of RV pacing, biventricular pacing(cardiac resynchronization therapy) devices can prevent the negative effects of RV pacing and reduce ventricular dyssynchrony. Therefore, cardiac resynchronization therapy has emerged as an attractive option with promising results and more clinical studies are underway. Furthermore, specific pacemaker algorithms, which minimize RV pacing, can also reduce the negative effects of RV stimulation on cardiac function and may prevent clinical deterioration. | Finn Akerstrm Miguel A Arias Marta Pachón Jesús Jiménez-López Alberto Puchol Justo Juliá-Calvo | 2013 | World Journal of Cardiology2013，5，11： | 3 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Morbidity and mortality after D1 and D2 gastrectomy for cancer: Interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial显示文摘 | M Degiuli M Sasako M Calgaro M Garino F Rebecchi M Mineccia D Scaglione D Andreone A Ponti F Calvo | 2004 | European Journal of Surgical Oncology2004，，3： | 2 |
| 4 | 晶粒细化对TWIP钢力学性能与织构的影响(英文)显示文摘奥氏体高锰钢(15%-30%)呈现出孪晶诱导塑性变形机制,并在拉伸试验中表现出很好的强度-塑性性能,因此在汽车工业结构件应用中有很大潜力。最近几年,对于TWIP钢不同方面的研究受到了高度重视。之前一些综述文章关注于TWIP钢的基本知识,而非晶粒细化方法的影响。本文主要综述了通过冷轧以及强塑性变形方法引起的力学性能改善以及织构变化。基于之前的研究,通过冷轧以及强塑性变形方法,平均晶粒尺度可以急剧地减小,同时屈服强度和极限抗拉强度将会大幅升高。这个现象可以归因于变形过程引起的孪晶演化。另一方面,在冷轧变形后,Goss和Brass织构会逐步形成。 | 王雷 BENITO J A CALVO J CABRERA J M | 2016 | 材料热处理学报2016，37，8： | 2 |
| 5 | Maintenance treatment with Pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study显示文摘 | Emilio Alba Manuel Ruiz-Borrego Mireia Margelí álvaro Rodríguez-Lescure Pedro Sánchez-Rovira Amparo Ruiz Jose Ramón Mel-Lorenzo Manuel Ramos-Vázquez Nuria Ribelles Elisa Calvo Antonio Casado Antonia Márquez David Vicente José Angel García-Sáenz Miguel Mar | 2010 | Breast Cancer Research and Treatment2010，，1： | 2 |
| 6 | A three-dimensional finite element analysis of the combined behavior of ligaments and menisci in the healthy human knee joint 显示文摘 | Pena E Calvo B Martinez M A | 2006 | Journal of Biomechanics2006，39，9： | 1 |
| 7 | Detection of radiolytic hydrocarbons by supercritical fluid extraction and gas chromatographic-mass spectrometric analysis of irradiated cheese显示文摘 | Barba C Calvo M M Herraiz M | 2009 | Food Chemistry2009，114，4： | 1 |
| 8 | Elimination of organic water pollutants using adsorbents obtained from sewage sludge 显示文摘 | Otero M Rozada F Calvo L F | 2003 | Dyes and Pigments2003，57，： | 1 |
| 9 | Evaluation of the hot ductility of a C-Mn steel produced from scrap recycling显示文摘 | CALVO J CABRERA J M REZAEIAN A | 2007 | ISIJ International2007，47，10： | 1 |
| 10 | Microsatellite based genetic diversity and population structure of the en-dangered Spanish Guadarrama goat breed显示文摘 | Serrano M Calvo J H Martínez M | 2009 | BMC Genetics2009，10，： | 1 |
| 11 | Experimental implementation of the gyrator transform 显示文摘 | RODRIGO J A AIAEVA T CALVO M L | 2007 | Journal of Optics Society of America A2007，24，10： | 1 |
| 12 | Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year r prospective study显示文摘 | Calvo C Pozo F Garcia-Garcia M L | 2010 | Acta Paediatrica2010，99，6： | 1 |
| 13 | A prospectivestudy of the prevalence of the polycystic ovary syndrome inunselected Caucasian women from Spain显示文摘 | Asuncion M Calvo RM San Millan JL | 2000 | J Clin EndocrinolMeTab2000，85，7： | 1 |
| 14 | Preindustrial to moderninterdecadal variability in coral reef pH显示文摘 | Pelejero C Calvo E McCulloch M T Marshall J F Gagan M K Lough J M Opdyke B N | 2005 | Science2005，309，5744： | 1 |
| 15 | Dosimetric characterization of a new preparation of BaSOa activated by Eu ions显示文摘 | GONZALEZ P R FURETTA C CALVO B E GASO M I CRUZ-ZARAGOZA E | 2007 | Nucl Instrum Meth B2007，260，： | 1 |
| 16 | Metabolic monitoring of postischemic myocardium during intermittent warm-blood cardioplegic administration显示文摘 | Borowski A Kurt M Calvo S | 2010 | Tex Heart Inst J2010，37，2： | 1 |
| 17 | Kinetic and equilibrium modeling of the methylene blue removal from solution by adsorbent materials produced from sewage sludge 显示文摘 | Otero M Rozada F Calvo LF | 2003 | Biochemical Engineering Journal2003，15，1： | 1 |
| 18 | Intedeukin 1-dependent and independent mouse melanoma metastasis显示文摘 | ANASAGASTI M J OLASO E CALVO F | 1997 | J Natl Cancer Inst1997，89，9： | 1 |
| 19 | Analysis of volatiles from Spanish honeys by solid-phase microextraction and gas chromatography-mass spectrometry显示文摘 | PEREZ R A SANCHEZ-BRUNETE C CALVO R M | 2002 | J Agrie Food Chem2002，50，9： | 1 |
| 20 | In vitro propagation oflavender显示文摘 | Calvo M C Segura J | 1989 | HortScience1989，24，： | 1 |
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