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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 5 |
| 3 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 4 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 3 |
| 5 | Thermal cracking of coal residues: Kinetics of asphaltene decomposition显示文摘 | MARTINEZ M T BENITO A M CALLEJAS M A | 1997 | Fuel1997，76，9： | 1 |
| 6 | Amino functionalized meso- structured SBA-15 silica for COz capture: Exploring the relation be- tween the adsorption capacity and the distribution of amino groups by TEM显示文摘 | Sanz R Calleja G Arencibia A | 2012 | Microp Mesop Mater2012，158，： | 1 |
| 7 | Clinical picture and prognostic factors for severe community-acquired pneumonia in adults admitted to the intensive care unit显示文摘 | Diaz A Mvarez M Callejas C | 2005 | Arch Brenconeumol2005，41，1： | 1 |
| 8 | Pityriasis lichenoides chronica:good response to photodynamic therapy显示文摘 | Fernandez GM Harto A Reguero Callejas ME | 2008 | Br J Dermatol2008，158，1： | 1 |
| 9 | Sustained effectiveness of osmotic-release meth- ylphenidate: A study of 266 cases显示文摘 | Ferndndez-Ja6n A Martin Ferndndez Mayoralas D Calleja P6rez B | 2009 | Rev Neurol2009，48，7： | 1 |
| 10 | Low cost single - stage electronic ballast based on a self oscillating resonant inverter in- tegrated with a buck - boost PFC circuit 显示文摘 | Ribas J Alonso J M Calleja A J | 2001 | IEEE Trans Nd Electron2001，48，6： | 1 |
| 11 | Structuremicrohardness relationship in semi-interpenetrating polymer networks 显示文摘 | Calleja F J B Privalko E G Fainleib A M | 2000 | Journal of Macromolecular Science-Physics B2000，39，2： | 1 |
| 12 | Intravenousthrombolysis in ischemic stroke with unknown onset using CTperfusion显示文摘 | Cortijo E Garcla-Bermejo P Calleja A I | | A cta Neurol Scand0，129，3： | 1 |
| 13 | Tumor markers in response monitoring and prognosis of non small cell lung cancer:preliminary report显示文摘 | Vinolas N Molina R Galan M C Casas F Callejas M A Filella X | 1998 | Anticancer Res1998，18，1： | 1 |
| 14 | HER-2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells显示文摘 | Kong A Calleja V Leboucher P | 2008 | PLoS One2008，3，8： | 1 |
| 15 | Single - stage high - power - factor self oscillating electronic ballast for fluorescent lamps with rapid start 显示文摘 | Ribas J Alonso J M Calleja A J | 2002 | Proceedings of the IEEEAPEC2002，，2000： | 1 |
| 16 | Structure and properties of ferroelectric copolymers of poly(vinylidene fluoride)显示文摘 | Balta Calleja F J Ezquerra A G | 1993 | Progress in Polymer Sci1993，18，1： | 1 |
| 17 | Crystallization mechanism of Fe-MFI from wetness impregnated Fe2O3-SiO2 amorphous xerogels: Role of iron species in Fenton-like processes 显示文摘 | Melero J A Calleja G Martinez F | 2004 | Microporous Meso- porous Mater2004，，74： | 1 |
| 18 | Production of biofuels via the catalytic cracking of mixtures of crude vegetable oils and nonedible animal fats with vacuum gas oil显示文摘 | MELERO J A CLAVERO M M CALLEJA G | 2010 | Energy Fuels2010，24，1： | 1 |
| 19 | III cranial nerve palsy mad brainstem disfunction following retro- bulbar anaesthesia显示文摘 | Armada Calleja MA Martinez Pueyo A Bellido Cuellar S | 2011 | Neurologia2011，26，9： | 1 |
| 20 | A universal- input single-stage high-power-factor power supply for HB-LEDs based on integrated buck-flyback converter显示文摘 | Gacio D Alonso J M Calleja A J | 2011 | IEEE Trans on Ind Electron2011，58，2： | 1 |
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